Increased stability and catalytic efficiency of yeast hexokinase upon interaction with zwitterionic micelles. Kinetics and conformational studies.

abstract：:Homologues of the putative dehydrogenase YjhC are found in operons involved in the metabolism of N-acetylneuraminate (Neu5Ac) or related compounds. We observed that purified recombinant YjhC forms Neu5Ac from two dehydrated forms of this compound, 2,7-anhydro-N-acetylneuraminate (2,7-AN) and 2-deoxy-2,3-didehydro-N-ac...

journal_title：Bioscience reports

authors： Kentache T,Thabault L,Peracchi A,Frédérick R,Bommer GT,Van Schaftingen E

更新日期：2020-06-26 00:00:00

abstract：:Osteoarthritis (OA) is one of the most common chronic joint disease. Long non-coding RNAs (lncRNAs) have been confirmed to play important roles in a variety of diseases including OA. However, the underlying mechanism of lncRNA differentiation antagonizing non-protein coding RNA (DANCR) in OA has not been well elucidat...

journal_title：Bioscience reports

authors： Zhang L,Zhang P,Sun X,Zhou L,Zhao J

更新日期：2018-12-14 00:00:00

abstract：:Insulin stimulated a concentration-dependent increase in protein synthesis in L6 myoblasts which was significant at 1 nM. This response was not prevented by the transcription inhibitor, actinomycin D. The protein kinase C (PKC) inhibitor, Ro-31-8220, and downregulation of PKC by prolonged incubation of cells with 12-O...

journal_title：Bioscience reports

authors： Thompson MG,Pascal M,Mackie SC,Thom A,Morrison KS,Backwell FR,Palmer RM

更新日期：1995-02-01 00:00:00

abstract：:In India, Sorghum plant allergenicity was reported to be approximately 54.9%. Sorghum bicolor Polcalcin (Sorb PC) was identified as the panallergen but the specificity of this allergen is yet to be characterized. The present study was aimed to characterize the antigenic determinants of Sorb PC that are responsible for...

journal_title：Bioscience reports

authors： Bokka CS,Veeramachaneni GK,Thunuguntla VBSC,Manda NK,Bondili JS

更新日期：2019-11-29 00:00:00

abstract：:Epidemiological studies have suggested inconclusive associations between 25-hydroxyvitamin D (25(OH)D) and survival in patients with colorectal cancer (CRC). The aim of the present study was to quantitatively assess these associations. PubMed, EMBASE, and Web of Science databases were systematically searched for eligi...

journal_title：Bioscience reports

authors： Wu G,Xue M,Zhao Y,Han Y,Zhang S,Zhang J,Li C,Xu J

更新日期：2020-07-31 00:00:00

abstract：:Erectile dysfunction (ED) is one of the significant complications of diabetes mellitus (DM), and CASR plays an important role in cellular antiapoptosis and NO production in the vascular endothelium by activating PKC. The present study was aimed to investigate the efficacy of Leech and Centipede Granules (LCG) through ...

journal_title：Bioscience reports

authors： Ma JX,Wang B,Ding CF,Li HS,Jiang XJ,Wang CY,Yu J,Chen WQ

更新日期：2020-02-28 00:00:00

abstract：:Mouse Mex3c encodes RNA-binding proteins of variant length through alternative splicing. Its mutation results in multiple defects including growth retardation, perturbed energy balance, and defective antiviral innate immunity. Here we report that Mex3c mutation affects mammary gland development and lactation in female...

journal_title：Bioscience reports

authors： Du Y,Sun D,Li Y

更新日期：2020-12-23 00:00:00

abstract：:Extracts from uterine cervical and body cancers, but not from benign tumor or intact tissues tested, were found to contain a growth-promoting activity which induced the proliferation of human endometrial fibroblasts. Exposure of cultured fibroblasts to the cancer extracts increased the rate of [3H]thymidine incorporat...

journal_title：Bioscience reports

authors： Imai A,Matsunami K,Iida K,Tamaya T

更新日期：1990-02-01 00:00:00

abstract：:Brain metastases are the most common intracranial tumors in adults. They usually originate from: lung, breast, renal cell and gastrointestinal cancers, as well as melanoma. Prognosis for brain metastases is still poor and classical treatment combining surgery and radiation therapy should be strongly supported with mol...

journal_title：Bioscience reports

authors： Barciszewska AM

更新日期：2018-10-22 00:00:00

abstract：:Hepatocellular carcinoma (HCC) has a high recurrence rate and poor clinical outcome after currently used therapies, including radiofrequency ablation. To explore the possible mechanisms for the relapse of HCC, in the present study we focussed on long non-coding RNA (LncRNA), which has been reported to be involved in t...

journal_title：Bioscience reports

authors： Zhu X,Yu H,Li B,Quan J,Zeng Z,Li G,Liu J

更新日期：2019-11-29 00:00:00

abstract：:To clarify the mechanism of circGOLPH3 regulation on prostate cancer cells, we performed an overexpression and interference circGOLPH3 assay in prostate cancer cells PC-3 and then evaluated cellular viability, proliferation, cell cycle, and apoptosis of prostate cancer cells by MTT, CCK8, Edu stain, TUNEL stain, and f...

journal_title：Bioscience reports

authors： Gong L,Tang Y,Jiang L,Tang W,Luo S

更新日期：2020-12-23 00:00:00

abstract：:This short article provides a comment on the recent article by Tauriainen et al. [Bioscience Reports (2018) 38, BSR20171274 https://doi.org/10.1042/BSR20171274]. ...

journal_title：Bioscience reports

authors： Plat J,Baumgartner S,Houben T,Vreugdenhil ACE,Mensink RP,Lütjohann D,Shiri-Sverdlov R

更新日期：2018-10-31 00:00:00

abstract：:When the amino-acid sequence of the 108-residue, rat tumour calcium-binding protein, oncomodulin, was aligned with that of rat muscle parvalbumin, 55 homologous positions were found, with an additional 33 single base-pair substitutions. This extensive homology, with virtual identity of the calcium-binding domains, sig...

journal_title：Bioscience reports

authors： MacManus JP,Watson DC,Yaguchi M

更新日期：1983-11-01 00:00:00

abstract：:Kawasaki disease (KD) is a type of disease that includes the development of a fever that lasts at least 5 days and involves the clinical manifestation of multicellular vasculitis. KD has become one of the most common pediatric cardiovascular diseases. Previous studies have reported that miR-218 rs11134527 A>G is assoc...

journal_title：Bioscience reports

authors： Pi L,Fu L,Xu Y,Che D,Deng Q,Huang X,Li M,Zhang L,Huang P,Gu X

更新日期：2018-05-22 00:00:00

abstract：:Doxorubicin (DOX) resistance in breast cancer largely results from the breast cancer stem cell like cells (BCSCs) which could be targetted to improve the efficacy of chemotherapy. Cell permeabilization using microbubbles (MBs) and ultrasound (US) have the potential for delivering molecules into the cytoplasm. We aim t...

journal_title：Bioscience reports

authors： Guo L,Zheng P,Fan H,Wang H,Xu W,Zhou W

更新日期：2017-11-09 00:00:00

abstract：:Objective: To explore whether aspirin (ASA) enhances the sensitivity of hepatocellular carcinoma (HCC) side population (SP) cells to doxorubicin (Doxo) via miR-491/ATP-binding cassette sub-family G member 2 (ABCG2).Methods: Non-SP and SP cells were isolated from MHCC-97L cell line using flow cytometry analysis and flu...

journal_title：Bioscience reports

authors： Xie ZY,Liu MS,Zhang C,Cai PC,Xiao ZH,Wang FF

更新日期：2018-11-09 00:00:00

abstract：:Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb) which has been threatening global public health for many years. High genetic diversity is dominant feature of Mtb. Increasing cases of multidrug-resistant (MDR) tuberculosis (MDR-TB) is a serious public health problem to TB control i...

journal_title：Bioscience reports

authors： Bai R,Chi S,Li X,Dai X,Ji Z,Jian M,Bi Y,Wang F,Ding Z,Luo L,Chen T,Liu A,Bao F

更新日期：2019-05-31 00:00:00

abstract：:The 7-nitro-2,1,3-nitrobenzoxadiazole (NBD) derivatives are a series of compounds containing the NBD scaffold that are not glutathione (GSH) peptidomimetics, and result in a strong inhibition of glutathione S-transferases (GSTs). Growing evidences highlight their pivotal roles and outstanding anticancer activity in di...

journal_title：Bioscience reports

authors： Sha HH,Wang Z,Dong SC,Hu TM,Liu SW,Zhang JY,Wu Y,Ma R,Wu JZ,Chen D,Feng JF

更新日期：2018-02-13 00:00:00

abstract：:Lung adenocarcinoma (LUAD) is the leading cause of cancer-related death worldwide, and its underlying mechanism remains unclear. Accumulating evidence has highlighted that long non-coding RNA (lncRNA) acts as competitive endogenous RNA (ceRNA) and plays an important role in the occurrence and development of LUAD. Here...

journal_title：Bioscience reports

authors： Yao Y,Zhang T,Qi L,Liu R,Liu G,Wang J,Song Q,Sun C

更新日期：2020-01-31 00:00:00

abstract：:More than 60 million people in the world have been diagnosed with HIV infections since the virus was recognized as the causative agent of AIDS in the 1980s. Even though more than half of the infected patients have died, effective disease treatment and prevention measures have not been established. ART (antiretroviral ...

journal_title：Bioscience reports

authors： Choi J,Jeong Y,Han HS,Lee KH

更新日期：2014-08-18 00:00:00

abstract：:This paper presents a short review of our contribution to the knowledge of the structure and function of human C1r, the activation unit of C1, the first component of the classical pathway of complement. On the basis of the domain structure of C1r, a model accounting for its autolytic activation mechanism is proposed. ...

journal_title：Bioscience reports

authors： Arlaud GJ,Colomb MG,Villiers CL

更新日期：1985-10-01 00:00:00

abstract：:Acute primary angle-closure (APAC) eyes show an early 'acute inflammatory' condition, while the inflammation condition has not been fully elucidated in the development of primary angle-closure glaucoma (PACG). To evaluate the roles of inflammatory cytokines in the pathogenesis of PACG, this cross-sectional study invol...

journal_title：Bioscience reports

authors： Wang Y,Chen S,Liu Y,Huang W,Li X,Zhang X

更新日期：2018-12-07 00:00:00

abstract：:Evidence is presented in support of a pathway in skeletal muscle of glyconeogenesis (glycogen biosynthesis de novo) from L-glutamate and related amino acids involving the enzyme phosphoenolpyruvate carboxykinase (PEP CK). In the rat hemidiaphragm in vitro, not only did L-[U]-14C]glutamate exert a glycogen-sparing acti...

journal_title：Bioscience reports

authors： Odedra BR,Palmer TN

更新日期：1981-02-01 00:00:00

abstract：:Peri-implantitis, which is characterized by dense inflammatory infiltrates and increased osteoclast activity, can lead to alveolar bone destruction and implantation failure. miRNAs participate in the regulation of various inflammatory diseases, such as periodontitis and osteoporosis. Therefore, the present study aimed...

journal_title：Bioscience reports

authors： Wu X,Chen X,Mi W,Wu T,Gu Q,Huang H

更新日期：2017-10-11 00:00:00

abstract：:The Gram-positive bacterium Staphylococcus pseudintermedius is a leading cause of canine bacterial pyoderma, resulting in worldwide morbidity in dogs. S. pseudintermedius also causes life-threatening human infections. Furthermore, methicillin-resistant S. pseudintermedius is emerging, resembling the human health threa...

journal_title：Bioscience reports

authors： Abate F,Malito E,Cozzi R,Lo Surdo P,Maione D,Bottomley MJ

更新日期：2014-11-24 00:00:00

abstract：:The association between dietary protein intake and ovarian cancer had been inconsistent in the previous epidemiological studies. The aim of the present study was to identify and synthesize all citations evaluating the relationship on ovarian cancer with protein intake. The search included PubMed, Embase, and Web of Sc...

journal_title：Bioscience reports

authors： Pang Y,Wang W

更新日期：2018-12-11 00:00:00

abstract：:As a zinc transporter, SLC39A7 (zip7) is vital in intestinal epithelial self-renewal, and recent studies suggested that SLC39A7 was related to cancer progression. Whereas, little is known about the role of SLC39A7 in gastric cancer (GC). In the present study, qRT-PCR analysis demonstrated that SLC39A7 mRNA level was i...

journal_title：Bioscience reports

authors： Zhang Y,Bai J,Si W,Yuan S,Li Y,Chen X

更新日期：2020-02-28 00:00:00

abstract：:To the best of our knowledge, this is the first study established a nomogram to predict survival probability in Asian patients with LSCC. A risk prediction nomogram for patients with LSCC, incorporating easily assessable clinicopathologic factors, generates more precise estimations of the survival probability when com...

journal_title：Bioscience reports

authors： Cui J,Wang L,Zhong W,Chen Z,Tan X,Yang H,Chen J,Liu G

更新日期：2020-08-28 00:00:00

abstract：:Aims: To identify the key differentially expressed genes (DEGs) in islet and investigate their potential pathway in the molecular process of type 2 diabetes.Methods: Gene Expression Omnibus (GEO) datasets (GSE20966, GSE25724, GSE38642) of type 2 diabetes patients and normal controls were downloaded from GEO database. ...

journal_title：Bioscience reports

authors： Zhong M,Wu Y,Ou W,Huang L,Yang L

更新日期：2019-05-31 00:00:00

abstract：:Chemical and physical stimuli trigger a cutaneous response by first inducing the main epidermal cells, keratinocytes, to produce specific mediators that are responsible for the initiation of skin inflammation. Activation modulates cell communication, namely leucocyte recruitment and blood-to-skin extravasation through...

journal_title：Bioscience reports

authors： Franchi J,Marteau C,Crola da Silva C,Mitterrand M,André P,Kieda C

更新日期：2008-02-01 00:00:00