C1r serine proteinase of human complement: a case of intramolecular autolytic activation.

abstract：OBJECTIVE:The role of lncRNAs in tumor has been widely concerned. The present study took HAS2-AS1 (the antisense RNA 1 of HAS2) as a starting point to explore its expression in glioma and its role in the process of migration and invasion, providing a strong theoretical basis for mining potential therapeutic targets of ...

journal_title：Bioscience reports

authors： Wang J,Gu J,You A,Li J,Zhang Y,Rao G,Ge X,Zhang K,Li J,Liu X,Wang Q,Lin T,Cheng L,Zhu M,Wu X,Wang D

更新日期：2020-08-28 00:00:00

abstract：:Rat ventral prostate incorporated (1-14C)acetate, (1-14C)palmitate and (1-14C)linoleate into different phospholipids in a time-dependent process. The rate of incorporation into total phospholipids was higher with linoleate (10.0 nmol/g) than with either palmitate (5.8 nmol/g) or acetate (4.7 nmol/g). Predominant label...

journal_title：Bioscience reports

authors： del Hoyo N,Pulido JA,Carretero MT,Pérez-Albarsanz MA

更新日期：1990-02-01 00:00:00

abstract：:Calmodulin-free ghost membranes were prepared from erythrocytes of kwashiorkor children and from healthy children in the same age bracket. In the absence of calmodulin, the specific activity of Mg2+-dependent Ca2+-pumping ATPase (Ca2+ + Mg2+-ATPase) of kwashiorkor membranes was more than 40 percent lower than the spec...

journal_title：Bioscience reports

authors： Olorunsogo OO

更新日期：1989-06-01 00:00:00

abstract：:Whether serum copper levels were higher in patients with cervical cancer than that in controls was controversial. Hence, we conducted the present study to explore the relationship between serum copper levels and cervical cancer. We searched PubMed, WanFang, and China National Knowledge Internet (CNKI) for relevant stu...

journal_title：Bioscience reports

authors： Zhang M,Shi M,Zhao Y

更新日期：2018-07-06 00:00:00

abstract：:A novel approach was used to assess the role of phosphoinositide hydrolysis in the mitogenic action of phytohemagglutinin (PHA) or concanavalin A (ConA). The treatment of human peripheral blood leukocytes (PBL) with monospecific antibodies against phospholipase C (PLC) produced a dose-dependent inhibition (up to 100%)...

journal_title：Bioscience reports

authors： Moraru II,Manciulea M,Călugăru A,Ghyka G,Popescu LM

更新日期：1987-09-01 00:00:00

abstract：:Cryptococcus neoformans is an opportunistic fungal pathogen that causes life-threatening meningitis primarily in immunocompromised individuals. In order to survive and proliferate during infection, C. neoformans must adapt to a variety of stresses it encounters within the host. Patient outcome depends on the interacti...

journal_title：Bioscience reports

authors： Altamirano S,Jackson KM,Nielsen K

更新日期：2020-10-30 00:00:00

abstract：:Imipramine and clorgyline, at concentrations of 0.002 M, inhibit the respiration of brain tissue by 82 and 71 per cent respectively, while chloropromazine and tranylcypromine, at concentrations of 0.01 M, inhibit it about 25 per cent. Deprenyl and amphetamine at a concentration of 0.002 M inhibit brain tissue respirat...

journal_title：Bioscience reports

authors： Nag M,Nandi N

更新日期：1991-02-01 00:00:00

abstract：:Many miRNAs play critical roles in modulating various biological processes of osteoclast differentiation and function. Microphthalmia-associated transcription factor (MITF), a target of miR-340, served as pivotal transcription factor involved in osteoclast differentiation. However, the role of miR-340 and MITF during ...

journal_title：Bioscience reports

authors： Zhao H,Zhang J,Shao H,Liu J,Jin M,Chen J,Huang Y

更新日期：2017-07-20 00:00:00

abstract：BACKGROUND:Glioblastoma (GBM) is the most common malignant brain tumor with a poor prognosis. The initial treatment for high-grade gliomas is surgical excision. However, even with concomitant use of radiation or chemotherapy, patients are still prone to recurrence. The specific pathogenesis of GBM is still controversia...

journal_title：Bioscience reports

authors： Xue L,Liu H,Chen Y,Wei L,Hong J

更新日期：2020-06-26 00:00:00

abstract：:It is well known that the amino acids in the blood are distributed between the plasma and inside the cells. This study was conducted to determine whether amino acids can be located adsorbed on blood cell membranes. The amino acid concentration in the deproteinized haemolysed blood was higher than that in the fraction ...

journal_title：Bioscience reports

authors： Picó C,Pons A,Palou A

更新日期：1991-08-01 00:00:00

abstract：:Escherichia coli accumulates K+ by means of multiple transport systems, of which TrkA is the most prominent at neutral and alkaline pH while Kup is major at acidic pH. In the present study, K+ uptake was observed with cells grown under fermentative conditions at an initial pH of 9.0 and 7.3 (the medium pH decreased to...

journal_title：Bioscience reports

authors： Trchounian A,Kobayashi H

更新日期：2000-08-01 00:00:00

abstract：:Circulating human neutrophils exhibited low rates of protein biosynthesis, as determined by their ability to incorporate [35S]methionine into TCA-precipitable material. Exposure of cells to the chemotactic peptide (N-formyl-L-methionyl-L-leucyl-L-phenylalanine) increased their rate of protein synthesis, and the maxima...

journal_title：Bioscience reports

authors： Hughes V,Humphreys JM,Edwards SW

更新日期：1987-11-01 00:00:00

abstract：:Recent experimental evidence increasingly shows that the dysregulation of cellular bioenergetics is associated with a wide array of common human diseases, including cancer, neurological diseases and diabetes. Respiration provides a vital source of cellular energy for most eukaryotic cells, particularly high energy dem...

journal_title：Bioscience reports

authors： Lal S,Alam MM,Hooda J,Shah A,Cao TM,Xuan Z,Zhang L

更新日期：2016-06-30 00:00:00

abstract：:Myelin Basic Protein, one of the major membrane protein component of the central nervous system, was used to probe the molecular mechanism of cellular activation by phytohaemagglutinin. Pre-treatment of human lymphocytes with myelin basic protein results in a lower rising of cytosolic concentration of free calcium aft...

journal_title：Bioscience reports

authors： Bellini T,Degani D,Matteuzzi M,Dallocchio F

更新日期：1990-02-01 00:00:00

abstract：:The cellular onc-genes c-src and c-yes are expressed very differently during chicken embryonic development. The c-src mRNA and its translational product are detectable at high levels in brain extracts of chicken embryos and adult chickens, whereas muscle extracts show an age-dependent decrease in the amounts of c-src-...

journal_title：Bioscience reports

authors： Gessler M,Barnekow A

更新日期：1984-09-01 00:00:00

abstract：:Mycoplasma pneumoniae is one of the most common pathogenic causes of community-acquired pneumonia. Hydrogen sulfide, alanine, and pyruvate producing enzyme (HapE) is a recently discovered M. pneumoniae virulence factor that can produce H2S to promote erythrocyte lysis. However, other cytotoxic effects of HapE have not...

journal_title：Bioscience reports

authors： Li S,Xue G,Zhao H,Feng Y,Yan C,Cui J,Sun H

更新日期：2019-01-18 00:00:00

abstract：:Although membrane fusion occurs ubiquitously and continuously in all eukaroytic cells, little is known about the mechanism that governs lipid bilayer fusion associated with any intracellular fusion reactions. Recent studies of the fusion of enveloped viruses with host cell membranes have helped to define the fusion pr...

journal_title：Bioscience reports

authors： Martin I,Ruysschaert JM

更新日期：2000-12-01 00:00:00

abstract：:The high proliferation rate of tumor cells demands high energy and metabolites that are sustained by a high glycolytic flux known as the 'Warburg effect'. The activation and further metabolism of glucose is initiated by hexokinase, a focal point of metabolic regulation. The human hexokinase 2 (HK2) is overexpressed in...

journal_title：Bioscience reports

authors： Nawaz MH,Ferreira JC,Nedyalkova L,Zhu H,Carrasco-López C,Kirmizialtin S,Rabeh WM

更新日期：2018-02-21 00:00:00

abstract：:A new method for detecting viral antibodies in cerebrospinal fluid is described. The technique has many advantages over previously published methods in that it is highly sensitive eliminating the need to concentrate the CSF, takes 5 h to complete, avoids the use of radionucleides, and most importantly circumvents prob...

journal_title：Bioscience reports

authors： Moyle S,Keir G,Thompson EJ

更新日期：1984-06-01 00:00:00

abstract：:Decreasing extracellular sodium concentration was found to produce a contractile response of rabbit ileal smooth muscle. As the concentration decreases, the amplitude of contraction increases, thus producing a dose-dependent curve. Harmaline, a competitor for sodium, was found to inhibit the sodium gradient-dependent ...

journal_title：Bioscience reports

authors： Suleiman MS

更新日期：1985-08-01 00:00:00

abstract：:Interleukins (ILs) are the most typical inflammatory and immunoregulatory cytokines. Evidences have shown that polymorphisms in ILs are associated with cerebral infarction risk. However, the results remain inconclusive. The present study was to evaluate the role of ILs polymorphisms in cerebral infarction susceptibili...

journal_title：Bioscience reports

authors： Wang J,Fan N,Deng Y,Zhu J,Mei J,Chen Y,Yang H

更新日期：2016-11-03 00:00:00

abstract：:PDC (pyruvate dehydrogenase complex) is a multi-enzyme complex comprising an E1 (pyruvate decarboxylase), an E2 (dihydrolipomide acetyltransferase) and an E3 (dihydrolipoamide dehydrogenase). PDC catalyses the decarboxylation of pyruvate and forms acetyl-CoA and NADH. In the human malaria parasite Plasmodium falciparu...

journal_title：Bioscience reports

authors： Laine LM,Biddau M,Byron O,Müller S

更新日期：2015-01-14 00:00:00

abstract：:Particulate membrane fractions from calf liver catalyze the release of glucose from GlcNAc2-Man9-Glc1-3-oligosaccharides. Maximal oligosaccharide-glucosidase activity was obtained at pH 6.2 and a detergent concentration of 0.5% Triton X-100. This activity could be distinguished from non-specific alpha-glucosidase acti...

journal_title：Bioscience reports

authors： Hettkamp H,Bause E,Legler G

更新日期：1982-11-01 00:00:00

abstract：:Ric c1, an allergenic protein from Ricinus communis , is an insect α-amylase inhibitor that has become an occupational allergen. Ric c1 can cross-react with allergens from wheat, soybean, peanut, shrimp, fish, gluten, house dust, tobacco, and air fungus, thereby amplifying the concern and risks caused by Ricinus aller...

journal_title：Bioscience reports

authors： Pacheco-Soares T,de Oliveira Carvalho A,da Silva Araújo J,de Souza GDS,Machado OLT

更新日期：2018-02-14 00:00:00

abstract：:LGMD (limb-girdle muscular dystrophy) and CMD (congenital muscular dystrophy) are two common forms of neuromuscular disorders which are distinguishable by their age of onset but with probably a similar underlying pathway. In the present study, we report immunohistochemical, Western-blot and genetic analyses in a large...

journal_title：Bioscience reports

authors： Hadj Salem I,Kamoun F,Louhichi N,Rouis S,Mziou M,Fendri-Kriaa N,Makni-Ayadi F,Triki C,Fakhfakh F

更新日期：2011-04-01 00:00:00

abstract：:Epilepsy is a common neurological disorder that affects mammalian species including human beings and dogs. In order to discover novel drugs for the treatment of canine epilepsy, multiomics data were analyzed to identify epilepsy associated genes. In this research, the original ranking of associated genes was obtained ...

journal_title：Bioscience reports

authors： Wang S,Meng X,Wang Y,Liu Y,Xia J

更新日期：2019-09-06 00:00:00

abstract：:Pregnant rabbit mammary gland explants cultured with insulin, prolactin and cortisol synthesize and secrete transferrin radiolabelled with [3H]leucine or [3H]mannose. Addition of tunicamycin inhibits the glycosylation but not synthesis of the [3H]leucine-labelled polypeptide. Secretion of the non-glycosylated protein ...

journal_title：Bioscience reports

authors： Bradshaw JP,White DA

更新日期：1985-03-01 00:00:00

abstract：:The 250-kDa sialoglycoprotein of bovine erythrocyte membranes, GP-2, has been found to be an exceptionally rich source of branched sialo-oligosaccharides of poly-N-acetyllactosamine (I antigen) type with receptor activity for the human pathogen Mycoplasma pneumoniae. Desialylated GP-2 is the most potent I-active subst...

journal_title：Bioscience reports

authors： Feizi T,Gooi HC,Loomes LM,Suzuki Y,Suzuki T,Matsumoto M

更新日期：1984-09-01 00:00:00

abstract：:Intervertebral disc degeneration is a disease identified as an inflammation response-participated pathological process. As a classical cellular feature, disc cell senescence is reported to be closely related with disc cell senescence. Resveratrol has a protective role against inflammation in some cells. However, its b...

journal_title：Bioscience reports

authors： Li X,Lin F,Wu Y,Liu N,Wang J,Chen R,Lu Z

更新日期：2019-05-10 00:00:00

abstract：:Chitinases catalyze the degradation of chitin, a ubiquitous polymer generated from the cell walls of fungi, shells of crustaceans, and cuticles of insects. They are gaining increasing attention in medicine, agriculture, food and drug industries, and environmental management. Their roles in the degradation of chitin fo...

journal_title：Bioscience reports

authors： Oyeleye A,Normi YM

更新日期：2018-08-29 00:00:00