Abstract:
:Significant amounts of somatostatin-like immunoreactivity (SLI) were detected in the extract of a human catecholamine-secreting adrenal medullary tumour. After salt fractionation and reconstitution the major portion of SLI was purified by gel filtration and two HPLC steps; in all three systems it eluted in the position of somatostatin-14. The purified somatostatin-like peptide inhibited, in a dose-related manner, growth hormone release from stimulated perfused rat anterior pituitary cells in vitro. Amino acid analysis showed the purified peptide to have an identical composition to somatostatin found in other species.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Corder R,Sykes JE,Lowry PJdoi
10.1007/BF01116377subject
Has Abstractpub_date
1982-03-01 00:00:00pages
147-54issue
3eissn
0144-8463issn
1573-4935journal_volume
2pub_type
杂志文章abstract::A few studies suggested the contribution of PPARs to the etiology of schizophrenia (SCZ). However, it is still not clear whether variants in PPAR-encoding genes have a direct association with SCZ. The potential linkage between SCZ and the variants within PPAR encoding genes (PPARA, PPARD, and PPARG) was tested in a la...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20201083
更新日期:2020-07-31 00:00:00
abstract::We aimed to confirm the role of miR-1296-5p in gastric cancer and to identify its target genes. The expression of miR-1296-5p was measured in gastric cancer tissues and cell lines. The function of miR-1296-5p was examined by the overexpression and inhibition of its expression in typical gastric cell lines as well as S...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181556
更新日期:2019-01-08 00:00:00
abstract::Background: Ki67 has been a key role for the treatment options and prognosis evaluation in some kinds of tumors; however, the spatial expression of Ki67 in oral squamous cell carcinoma (OSCC) has not been fully-evaluated. Therefore, in the present study, we aimed to elucidate the prognosis value of Ki67 spatial expres...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181271
更新日期:2018-11-20 00:00:00
abstract::Abnormal aggregation of pathological tau protein is a neuropathological feature of Alzheimer's disease (AD). In the AD patients, the abnormal tau accumulation first appeared in entorhinal cortex (EC) and then propagated to the hippocampus with microglia activation and inflammation, but the mechanism is elusive. Here, ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20193629
更新日期:2020-02-28 00:00:00
abstract::The principle of the dual inhibitor titration method for testing models of electron-transport phosphorylation is outlined, and the method is applied to the study of photophosphorylation in bacterial chromatophores. It is concluded that energy coupling is strictly localized in nature in this system, in the sense that f...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01114933
更新日期:1982-10-01 00:00:00
abstract::Goblet cells (GCs) are single-cell glands that produce and secrete mucin. Mucin forms a mucus layer, which can separate the materials in cavities from the intestinal epithelium and prevent the invasion of pathogenic microorganisms in various ways. GCs can also participate in the immune response through nonspecific end...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20201471
更新日期:2020-10-30 00:00:00
abstract:BACKGROUND:Glioblastoma (GBM) is the most common malignant brain tumor with a poor prognosis. The initial treatment for high-grade gliomas is surgical excision. However, even with concomitant use of radiation or chemotherapy, patients are still prone to recurrence. The specific pathogenesis of GBM is still controversia...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20201401
更新日期:2020-06-26 00:00:00
abstract::The exon junction complex (EJC) is the main mechanism by which cells select specific mRNAs for translation into protein. We hypothesized that the EJC is involved in the regulation of gene expression during the stress response in cardiac myocytes, with implications for the failing heart. In cultured rat neonatal myocyt...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20170707
更新日期:2017-07-07 00:00:00
abstract::Acute lymphoblastic leukemia (ALL) is the most common cancer in children, and alterations in CDKN2A were considered to play an important role on leukemogenesis. Two single nucleotide polymorphisms (SNPs) at CDKN2A locus were identified to impact on ALL susceptibility via genome wide association studies, and followed b...
journal_title:Bioscience reports
pub_type: 杂志文章,meta分析,评审
doi:10.1042/BSR20180331
更新日期:2018-06-27 00:00:00
abstract::Heterotopic ossification (HO) is the aberrant formation of mature, lamellar bone in nonosseous tissue. Fibrodysplasia ossificans progressiva (FOP) is a rare and devastating genetic disorder that causes progressive HO in the ligaments, tendons, and muscles throughout the body. FOP is attributed to an autosomal mutation...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1042/BSR20190377
更新日期:2019-08-02 00:00:00
abstract::Ric c1, an allergenic protein from Ricinus communis , is an insect α-amylase inhibitor that has become an occupational allergen. Ric c1 can cross-react with allergens from wheat, soybean, peanut, shrimp, fish, gluten, house dust, tobacco, and air fungus, thereby amplifying the concern and risks caused by Ricinus aller...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20171245
更新日期:2018-02-14 00:00:00
abstract::This review focuses on the recent developments in the study of drug interactions with biological membranes and membrane-associated proteins using nuclear magnetic resonance (NMR) spectroscopy and other spectroscopic techniques. Emphasis is placed on a class of low-affinity neurological agents as exemplified by volatil...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1023/a:1020182404940
更新日期:2002-04-01 00:00:00
abstract::A family of artificial proteins, named αRep, based on a natural family of helical repeat was previously designed. αRep members are efficiently expressed, folded and extremely stable proteins. A large αRep library was constructed creating proteins with a randomized interaction surface. In the present study, we show tha...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20150080
更新日期:2015-06-12 00:00:00
abstract::When the amino-acid sequence of the 108-residue, rat tumour calcium-binding protein, oncomodulin, was aligned with that of rat muscle parvalbumin, 55 homologous positions were found, with an additional 33 single base-pair substitutions. This extensive homology, with virtual identity of the calcium-binding domains, sig...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01121034
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND:Annulus fibrosus (AF) is important to confine disc nucleus pulposus (NP) tissue during mechanical load experience. However, the knowledge on AF cell biology under mechanical load is much limited compared with disc NP. OBJECTIVE:The present study aimed to investigate responses of apoptosis and matrix metabol...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20182375
更新日期:2019-02-22 00:00:00
abstract::CXCL8, a member of CXC chemokines, was constitutively expressed in many types of human cancers, and its overexpression has been shown to play a critical role in promoting tumorigenesis. The purpose of the present study was to determine CXCL8 expression in a commercial human liver tissue microarray, and elucidate the e...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20201169
更新日期:2020-08-28 00:00:00
abstract::Fungal endophytes are known to secrete a large array of secondary metabolites (phenols, flavonoids, indole acetic acid (IAA) etc.) that facilitate crops under stress conditions. Considering this, a potent plant growth promoting endophyte (SXSp1) from the spines and leaves of Solanum xanthocarpum L. has been isolated. ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190290
更新日期:2019-10-30 00:00:00
abstract::Ehrlich Ascites Tumour cells were irradiated with UV-light to crosslink DNA to proteins in vivo. The DNA fragments associated with the nuclear lamina were purified and characterized. The results of the Cot analysis and the hybridization experiments suggest that the DNA fragments attached to the nuclear lamina although...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01119802
更新日期:1989-10-01 00:00:00
abstract::Virus replication inhibitory peptide (carbobenzoxy-D-Phe-L-PheGly) was shown to be a potent specific inhibitor of the replication of paramyxovirus and myxovirus (Richardson, Scheid and Choppin (1980), Virology 105, 205-222). This peptide inhibits the membrane fusing activity of a viral glycoprotein. Many agents which ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01114759
更新日期:1986-07-01 00:00:00
abstract::Ovarian cancer is a highly lethal cancer in females. Therefore, it is necessary to explore effective biomarkers for the diagnosis and prognosis of the disease. Stratifin (SFN) is a cell cycle checkpoint protein that has been reported to be involved in oncogenesis. Our studies detected the expression of SFN in ovarian ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190100
更新日期:2019-05-02 00:00:00
abstract::Human cytomegalovirus (HCMV) infection can cause inflammatory tissue-invasive end-organ diseases upon lytic replication. In humans, mature miR-200b-3p and -200c-3p suppress the synthesis of HCMV immediate early 2 (IE2) protein by binding to the 3'-UTR of the mRNA encoded by the unique long (UL) 122-123 region in human...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180961
更新日期:2018-12-07 00:00:00
abstract::Sendai virus envelopes (SVE) were isolated from Sendai virus particles by Triton X-100 solubilization and ultracentrifugation. The envelopes were reconstituted in the presence of the fluorescent dye calcein by gradual removal of the detergent with Bio-beads SM-2. The internal volume of reconstituted Sendai virus envel...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01121911
更新日期:1984-07-01 00:00:00
abstract::Using a quantitative enzyme immunoassay, Thy-1 antigen expressed by a rat myoid cell line R615B2 was detected mainly on the cell surface at a single cell stage, whereas at the stage of forming myotubes, Thy-1 was found predominantly in the cytoplasm. The muscle specific creatine kinase activity also increased in assoc...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01119804
更新日期:1989-10-01 00:00:00
abstract::Heparin causes lysis of the multilamellar liposomes of all three charges, positive, neutral, and negative, and thus releases the entrapped [3H]glucose or chromate. The lytic effect of heparin is also observed in liposomes prepared from the lipids extracted from human red blood cells. Heparin is found to interact with ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01121569
更新日期:1983-01-01 00:00:00
abstract::A possible role for Ca2+ and calmodulin in the action of growth-hormone-releasing factor (GHRF) was investigated. Low extracellular Ca2+ (less than 100 microM), methoxyverapamil, flunarizine, cinnarizine, and Co2+ decreased both basal and GHRF-stimulated growth-hormone secretion, but did not totally inhibit GHRF-stimu...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116691
更新日期:1984-12-01 00:00:00
abstract::The present study estimates the effect of rivaroxaban on preventing deep vein thrombosis (DVT) in aged diabetics with femoral neck fractures after hip replacement. Our study consisted of 236 aged diabetics with femoral neck fractures, which were divided into the rivaroxaban and control groups. Reaction time (R time), ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20170289
更新日期:2017-06-21 00:00:00
abstract::Circulating tumor cells can provide important diagnostic and prognostic information of the patients with non-small cell lung cancer (NSCLC). Aldehyde dehydrogenase 1 (ALDH1), a cancer stem cell marker, has been used in various tumors, including NSCLC. In the present study, we isolated the circulating ALDH1+ tumor cell...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180914
更新日期:2018-10-31 00:00:00
abstract::Bleaching of the purple membrane strongly reduces the number of divalent cation binding sites as well as their affinities. Conversely, deionization of the bleached membrane drastically inhibits the chromophore regeneration. Proteolysis experiments using bromelain show that the bleached membrane has an additional cleav...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01114972
更新日期:1986-11-01 00:00:00
abstract::This study proposed a deep learning (DL) algorithm to predict survival in patients with colon adenocarcinoma (COAD) based on multi-omics integration. The survival-sensitive model was constructed using an autoencoder for DL implementation based on The Cancer Genome Atlas (TCGA) data of patients with COAD. The autoencod...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20201482
更新日期:2020-12-01 00:00:00
abstract::A range of different types of interactions at biological membrane surfaces have been studied using various different spin label electron spin resonance (ESR) techniques. These include: (1) the interfacial ionization of local anaesthetics, (2) the binding of peripheral membrane proteins, (3) the membrane insertion of t...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1023/a:1020590122846
更新日期:1999-08-01 00:00:00