Characterization of FANCL variants observed in patient cancer cells.

abstract：:Nonsmall cell lung cancer (NSCLC) is one of the most frequent malignancies worldwide. Long noncoding RNAs (LncRNAs) play critical roles in cancer initiation and progression. Previous studies have demonstrated that overexpression of cytoskeleton regulator RNA (CYTOR) predicates poor prognosis and promotes tumor progres...

journal_title：Bioscience reports

authors： Zhang J,Li W

更新日期：2018-12-18 00:00:00

abstract：:This study proposed a deep learning (DL) algorithm to predict survival in patients with colon adenocarcinoma (COAD) based on multi-omics integration. The survival-sensitive model was constructed using an autoencoder for DL implementation based on The Cancer Genome Atlas (TCGA) data of patients with COAD. The autoencod...

journal_title：Bioscience reports

authors： Lv J,Wang J,Shang X,Liu F,Guo S

更新日期：2020-12-01 00:00:00

abstract：:Common colds were shortened by 7 days in a 1984 clinical trial using zinc gluconate throat lozenges each 2 h. Between then and 2004, 10 other double-blind, placebo-controlled clinical trials showed widely varying results. This re-analysis of these trials presents solution chemistry methods to elucidate differences in ...

journal_title：Bioscience reports

authors： Eby GA

更新日期：2004-02-01 00:00:00

abstract：:Cardiac hypertrophy is a compensatory response to stress or stimuli, which results in arrhythmia and heart failure. Although multiple molecular mechanisms have been identified, cardiac hypertrophy is still difficult to treat. Pyroptosis is a caspase-1 dependent pro-inflammatory programmed cell death. Caspase-1 is invo...

journal_title：Bioscience reports

authors： Bai Y,Sun X,Chu Q,Li A,Qin Y,Li Y,Yue E,Wang H,Li G,Zahra SM,Dong C,Jiang Y

更新日期：2018-02-12 00:00:00

abstract：:Epidemiological studies have suggested inconclusive associations between 25-hydroxyvitamin D (25(OH)D) and survival in patients with colorectal cancer (CRC). The aim of the present study was to quantitatively assess these associations. PubMed, EMBASE, and Web of Science databases were systematically searched for eligi...

journal_title：Bioscience reports

authors： Wu G,Xue M,Zhao Y,Han Y,Zhang S,Zhang J,Li C,Xu J

更新日期：2020-07-31 00:00:00

abstract：:The secretory process is a coordinated cellular response, initiated by occupation of surface receptors and comprising an ordered sequence of biochemical steps subject to multiple controls. Conceptually we can divide the sequence into two main sections comprising early, receptor-mediated events leading to generation of...

journal_title：Bioscience reports

authors： Gomperts BD,Cockcroft S,Howell TW,Nüsse O,Tatham PE

更新日期：1987-05-01 00:00:00

abstract：:As a zinc transporter, SLC39A7 (zip7) is vital in intestinal epithelial self-renewal, and recent studies suggested that SLC39A7 was related to cancer progression. Whereas, little is known about the role of SLC39A7 in gastric cancer (GC). In the present study, qRT-PCR analysis demonstrated that SLC39A7 mRNA level was i...

journal_title：Bioscience reports

authors： Zhang Y,Bai J,Si W,Yuan S,Li Y,Chen X

更新日期：2020-02-28 00:00:00

abstract：:Neuroblastoma, which accounts for approximately 10% of all pediatric cancer-related deaths, has become a therapeutic challenge and global burden attributed to poor outcomes and mortality rates of its high-risk form. Previous genome-wide association studies (GWASs) identified the LINC00673 rs11655237 C>T polymorphism t...

journal_title：Bioscience reports

authors： Zhang Z,Chang Y,Jia W,Zhang J,Zhang R,Zhu J,Yang T,Xia H,Zou Y,He J

更新日期：2018-02-08 00:00:00

abstract：:Western blotting was used as a powerful alternative to immunoprecipitation for the detection of the simian virus 40 (SV40) large tumor (T) antigen. After resolution by electrophoresis on a SDS-polyacrylamide gel of a [35S]methionine labeled crude extract from SV40 infected monkey kidney cells, the separated proteins w...

journal_title：Bioscience reports

authors： Dietrich JB

更新日期：1985-02-01 00:00:00

abstract：:Specific binding sites for somatostatin have been found in the cytosolic fractions of both parietal and non-parietal cells from rabbit gastric fundic mucosa. The stoichiometric data suggested the presence of two classes of binding sites in both types of cells. The number of low-affinity binding sites was significantly...

journal_title：Bioscience reports

authors： Arilla E,López-Ruiz MP,Gonzalez-Guijarro L,Prieto JC

更新日期：1985-04-01 00:00:00

abstract：:Gastric cancer (GC) is one of the most prevalent gastrointestinal malignancies. Long noncoding RNA (lncRNA) DANCR is a newly identified oncogenic lncRNA. However, the functional role and underlying molecular mechanisms of DANCR involved in GC progress remain unclear. In the present study, we investigated the biologica...

journal_title：Bioscience reports

authors： Mao Z,Li H,Du B,Cui K,Xing Y,Zhao X,Zai S

更新日期：2017-11-06 00:00:00

abstract：:A range of different types of interactions at biological membrane surfaces have been studied using various different spin label electron spin resonance (ESR) techniques. These include: (1) the interfacial ionization of local anaesthetics, (2) the binding of peripheral membrane proteins, (3) the membrane insertion of t...

journal_title：Bioscience reports

authors： Marsh D

更新日期：1999-08-01 00:00:00

abstract：:It is well known that the amino acids in the blood are distributed between the plasma and inside the cells. This study was conducted to determine whether amino acids can be located adsorbed on blood cell membranes. The amino acid concentration in the deproteinized haemolysed blood was higher than that in the fraction ...

journal_title：Bioscience reports

authors： Picó C,Pons A,Palou A

更新日期：1991-08-01 00:00:00

abstract：:This is the first report of its kind that well demonstrates that a lectin from Phytolacca americana [Pa-2 (P. americana lectin-2)] can also be intrinsically unordered, based on the results obtained by CD, tryptophan fluorescence, ANS (8-anilinonaphthalene-1-sulfonic acid) binding, acrylamide quenching, DLS (dynamic li...

journal_title：Bioscience reports

authors： Ahmad E,Kamranur Rahman S,Masood Khan J,Varshney A,Hasan Khan R

更新日期：2009-11-23 00:00:00

abstract：:Reactive oxygen species (ROS) overproduction and renal tubular epithelial cell (TEC) apoptosis are key mechanisms of contrast-induced acute kidney injury (CI-AKI). Mitochondria are the main source of intracellular ROS. In the present study, the characteristics of mitophagy and the effects of rapamycin on contrast-indu...

journal_title：Bioscience reports

authors： Yang X,Yan X,Yang D,Zhou J,Song J,Yang D

更新日期：2018-11-20 00:00:00

abstract：:In a study of Necturus gallbladder epithelium Benzel et al. (Benzel et al., 1980) found that low (0.2-1.2 microM) and higher concentrations (1.5 microM and more) of cytochalasin B (CB) caused an increase and decrease in the transepithelial electrical resistance (TER), respectively. Moreover, there were slight changes ...

journal_title：Bioscience reports

authors： Nybom P,Magnusson KE

更新日期：1996-08-01 00:00:00

abstract：:Breast cancer remains a leading cause of cancer-related mortality in women. In recent years, regulation of genes involved in heparan sulphate (HS) biosynthesis have received increased interest as regulators of breast cancer cell adhesion and invasion. The exostosin (EXT) proteins are glycosyltransferases involved in e...

journal_title：Bioscience reports

authors： Sembajwe LF,Katta K,Grønning M,Kusche-Gullberg M

更新日期：2018-08-31 00:00:00

abstract：:Two established cancer cell lines, MCF-7 and Ishikawa, were both obtained directly from a cell repository and through another laboratory. The karyotypes from the two MCF-7 cell lines had up to 83 chromosomes and similarities for chromosomal gain and structural abnormalities. The two Ishikawa cell lines had up to 60 ch...

journal_title：Bioscience reports

authors： Wenger SL,Senft JR,Sargent LM,Bamezai R,Bairwa N,Grant SG

更新日期：2004-12-01 00:00:00

abstract：:Folic acid (FA), which is necessary for normal cell division of mammals, has been implicated to be involved in many tumors. Dietary FA intake has been reported to be associated with a lower risk of nasopharyngeal cancer (NPC). However, the molecular mechanisms of FA in NPC cells remain unclear. In the present study, w...

journal_title：Bioscience reports

authors： Liu Z,Jin X,Pi W,Liu S

更新日期：2017-12-05 00:00:00

abstract：:To observe the effect of gene expression and tumorigenicity in hybrid cells of human embryonic stem cells (hESCs) and ovarian cancer cells in vitro and in vivo using a mouse model, and to determine its feasibility in reprogramming tumour cells growth and apoptosis, for a potential exploration of the role of hESCs and ...

journal_title：Bioscience reports

authors： He K,Qu H,Xu LN,Gao J,Cheng FY,Xiang P,Zhou CQ

更新日期：2016-09-16 00:00:00

abstract：:The growth arrest special 5 (GAS5), as a research hotspot of long noncoding RNAs (lncRNAs), has been reported to be associated with colorectal cancer (CRC). However, the association between polymorphisms in GAS5 and the risk of CRC was not clear. In the present study, a case-control study in 1078 CRC patients and 1175...

journal_title：Bioscience reports

authors： Wang Y,Wu S,Yang X,Li X,Chen R

更新日期：2019-04-16 00:00:00

abstract：:3D (three-dimensional) cultures are considered to be an effective method for toxicological studies; however, little evidence has been reported whether 3D cultures have an impact on hepatocellular physiology regarding lipid or glucose metabolism. In the present study, we conducted physiological characterization of hepa...

journal_title：Bioscience reports

authors： Takahashi Y,Hori Y,Yamamoto T,Urashima T,Ohara Y,Tanaka H

更新日期：2015-05-07 00:00:00

abstract：:In order to better understand the role of cell surface glycolipids in T lymphocyte activation, heparin was used to simultaneously modulate the expression of glycolipids and the lytic capacity of lymphocytes activated by interleukin-2. Results presented here show that heparin added at the start of a 3 day culture inhib...

journal_title：Bioscience reports

authors： Schwarting GA,Gajewski A

更新日期：1988-08-01 00:00:00

abstract：:The association between dietary protein intake and ovarian cancer had been inconsistent in the previous epidemiological studies. The aim of the present study was to identify and synthesize all citations evaluating the relationship on ovarian cancer with protein intake. The search included PubMed, Embase, and Web of Sc...

journal_title：Bioscience reports

authors： Pang Y,Wang W

更新日期：2018-12-11 00:00:00

abstract：:Glycine methyl ester, an inhibitor of transglutaminase, decreased glucose-stimulated insulin release and delayed proinsulin conversion in rat pancreatic islets pulse-labelled with L-[4-3H]phenylalanine. Sarcosine methyl ester, which does not inhibit transglutaminase activity, failed to affect insulin release and proin...

journal_title：Bioscience reports

authors： Alarcon C,Valverde I,Malaisse WJ

更新日期：1985-07-01 00:00:00

abstract：:The effect of carbamylcholine and the calcium ionophore A23187 on catecholamine release and intracellular free calcium, [Ca2+]i, in bovine adrenal chromaffin cells was determined. At 10(-4) M carbamylcholine maximal release occurred with an accompanying increase in [Ca2+]i from a basal level of 168 nM to less than 300...

journal_title：Bioscience reports

authors： Burgoyne RD

更新日期：1984-07-01 00:00:00

abstract：:Brain metastases are the most common intracranial tumors in adults. They usually originate from: lung, breast, renal cell and gastrointestinal cancers, as well as melanoma. Prognosis for brain metastases is still poor and classical treatment combining surgery and radiation therapy should be strongly supported with mol...

journal_title：Bioscience reports

authors： Barciszewska AM

更新日期：2018-10-22 00:00:00

abstract：:Radiotherapy is the primary treatment option for nasopharyngeal carcinoma (NPC). Local recurrence and metastasis caused by radioresistance become a bottleneck of curative effect for patients with NPC. Currently, serum predictive biomarkers of radioresistance are scare. We enrolled NPC patients, who underwent radiother...

journal_title：Bioscience reports

authors： Zhang G,Zhang K,Li C,Li Y,Li Z,Li N,Zhou Q,Shen L

更新日期：2019-05-14 00:00:00

abstract：:Increasing studies are indicating that long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is associated with the prognosis of cancer patients. However, the results have been disputed. Therefore, we aimed to further explore the prognostic value and clinical significance of XIST in various types of cance...

journal_title：Bioscience reports

authors： Liu X,Ming X,Jing W,Luo P,Li N,Zhu M,Yu M,Liang C,Tu J

更新日期：2018-06-21 00:00:00

abstract：:The coupling of the chemical reaction of ATP hydrolysis to the transport of calcium from the cytoplasm into the lumen of sarcoplasmic reticulum vesicles can be defined by a set of rules that define alternating changes in the specificities of the enzyme for catalysis of chemical and physical reactions. ...

journal_title：Bioscience reports

authors： Jencks WP

更新日期：1995-10-01 00:00:00