Biosynthetic capacity of hepatocytes after storage at 4 degrees C.


:Capacity to synthesize glucose, urea, and ketone bodies is well maintained in hepatocytes after storage for at least 24 h at 4 degrees C. Substrates and albumin are the only requirements.


Biosci Rep


Bioscience reports


Farrell R,Lund P





Has Abstract


1983-06-01 00:00:00












  • Clusterin role in hepatocellular carcinoma patients treated with oxaliplatin.

    abstract:AIM:To explore the prognostic value of clusterin (CLU) in hepatocellular carcinoma (HCC) patients treated with oxaliplatin (OXA). METHODS:Relative expression of plasma CLU mRNA was examined via fluorescence quantitative real-time PCR (qRT-PCR), and CLU protein level in tissue samples was detected through immunohistoch...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Wang X,Liu Y,Qin Q,Zheng T

    更新日期:2020-02-28 00:00:00

  • Chromatin target of protein arginine methyltransferase regulates invasion, chemoresistance, and stemness in epithelial ovarian cancer.

    abstract::Ovarian cancer is one of the most common gynecological cancers with a high mortality rate in females. Chromatin target of protein arginine methyltransferase (CHTOP) is an important intracellular protein that regulates the transcriptional activation of several oncogenic genes in glioblastomagenesis and controls mature ...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Feng X,Li L,Wang L,Luo S,Bai X

    更新日期:2019-04-16 00:00:00

  • Latent human leukocyte collagenase can be activated by gold thioglucose and gold sodium thiomalate, but not by auranofin.

    abstract::Gold thioglucose and gold sodium thiomalate were shown to be potent activators of latent human leukocyte collagenase. No activation by auranofin was noted. The activation may proceed through the action of gold on the essential sulfhydryl groups of latent enzyme and, thereby, mimick the action of the known organomercur...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Sorsa T,Suomalainen K,Turto H,Lindy S

    更新日期:1987-12-01 00:00:00

  • Phosphatidylserine and Phosphatidylethanolamine Regulate the Structure and Function of FVIIaand Its Interaction with Soluble Tissue Factor.

    abstract::Cell membranes have important functions in many steps of the blood coagulation cascade, including the activation of factor X (FX) by the factor VIIa (FVIIa)-tissue factor (TF) complex (extrinsic Xase). FVIIa shares structural similarity with factor IXa (FIXa) and FXa. FIXa and FXa are regulated by binding to phosphati...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Sengupta T,Koklic T,Lentz BR,Majumder R

    更新日期:2021-01-22 00:00:00

  • The prognostic roles of circulating ALDH1+ tumor cell in the patients with non-small cell lung cancer.

    abstract::Circulating tumor cells can provide important diagnostic and prognostic information of the patients with non-small cell lung cancer (NSCLC). Aldehyde dehydrogenase 1 (ALDH1), a cancer stem cell marker, has been used in various tumors, including NSCLC. In the present study, we isolated the circulating ALDH1+ tumor cell...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Tian S,Xing YN,Xia P

    更新日期:2018-10-31 00:00:00

  • Efficacy of liraglutide in treating type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease.

    abstract::Type 2 diabetes mellitus (T2DM) complicated with non-alcoholic fatty liver disease (NAFLD) is difficult to treat. The present study explored the efficacy of (liraglutide) Lira in treating T2DM complicated with NAFLD. A total of 127 patients suffering from T2DM complicated with NAFLD were enrolled in the present study,...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Tian F,Zheng Z,Zhang D,He S,Shen J

    更新日期:2018-12-21 00:00:00

  • Degradation of side-chains of N-(2-hydroxypropyl)methacrylamide copolymers by lysosomal thiol-proteinases.

    abstract::N-(2-Hydroxypropyl)methacrylamide copolymers bearing oligopeptide side-chains terminating in p-nitroaniline (NAp) were incubated with rat liver lysosomal enzymes in the presence of the thiol glutathione, and the rate of p-nitroaniline release was measured. Twelve of the 16 side-chains investigated were hydrolysed to r...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Duncan R,Cable HC,Lloyd JB,Rejmanová P,Kopecek J

    更新日期:1982-12-01 00:00:00

  • Localized energy coupling during photophosphorylation by chromatophores of Rhodopseudomonas capsulata N22.

    abstract::The principle of the dual inhibitor titration method for testing models of electron-transport phosphorylation is outlined, and the method is applied to the study of photophosphorylation in bacterial chromatophores. It is concluded that energy coupling is strictly localized in nature in this system, in the sense that f...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Hitchens GD,Kell DB

    更新日期:1982-10-01 00:00:00

  • Comprehensive analysis of prognostic biomarkers in lung adenocarcinoma based on aberrant lncRNA-miRNA-mRNA networks and Cox regression models.

    abstract::Lung adenocarcinoma (LUAD) is the leading cause of cancer-related death worldwide, and its underlying mechanism remains unclear. Accumulating evidence has highlighted that long non-coding RNA (lncRNA) acts as competitive endogenous RNA (ceRNA) and plays an important role in the occurrence and development of LUAD. Here...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Yao Y,Zhang T,Qi L,Liu R,Liu G,Wang J,Song Q,Sun C

    更新日期:2020-01-31 00:00:00

  • Norepinephrine inhibits energy metabolism of human peripheral blood mononuclear cells via adrenergic receptors.

    abstract::Previous studies demonstrated that the adaptive response to stressors and inflammatory signals involves the activation of the autonomous [corrected] nervous system. Catecholamines have been shown to modulate the activity of various immune effector cells directly via membrane adrenergic receptors. Here, we investigated...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Lünemann JD,Buttgereit F,Tripmacher R,Baerwald CG,Burmester GR,Krause A

    更新日期:2001-10-01 00:00:00

  • Structure and ligand binding of As-p18, an extracellular fatty acid binding protein from the eggs of a parasitic nematode.

    abstract::Intracellular lipid-binding proteins (iLBPs) of the fatty acid-binding protein (FABP) family of animals transport, mainly fatty acids or retinoids, are confined to the cytosol and have highly similar 3D structures. In contrast, nematodes possess fatty acid-binding proteins (nemFABPs) that are secreted into the perivit...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Ibáñez-Shimabukuro M,Rey-Burusco MF,Gabrielsen M,Franchini GR,Riboldi-Tunnicliffe A,Roe AJ,Griffiths K,Cooper A,Córsico B,Kennedy MW,Smith BO

    更新日期:2019-07-23 00:00:00

  • Serum proteomics identify potential biomarkers for nasopharyngeal carcinoma sensitivity to radiotherapy.

    abstract::Radiotherapy is the primary treatment option for nasopharyngeal carcinoma (NPC). Local recurrence and metastasis caused by radioresistance become a bottleneck of curative effect for patients with NPC. Currently, serum predictive biomarkers of radioresistance are scare. We enrolled NPC patients, who underwent radiother...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Zhang G,Zhang K,Li C,Li Y,Li Z,Li N,Zhou Q,Shen L

    更新日期:2019-05-14 00:00:00

  • LncRNA DANCR promotes migration and invasion through suppression of lncRNA-LET in gastric cancer cells.

    abstract::Gastric cancer (GC) is one of the most prevalent gastrointestinal malignancies. Long noncoding RNA (lncRNA) DANCR is a newly identified oncogenic lncRNA. However, the functional role and underlying molecular mechanisms of DANCR involved in GC progress remain unclear. In the present study, we investigated the biologica...

    journal_title:Bioscience reports

    pub_type: 杂志文章,收录出版


    authors: Mao Z,Li H,Du B,Cui K,Xing Y,Zhao X,Zai S

    更新日期:2017-11-06 00:00:00

  • Genetic and structural validation of Aspergillus fumigatus N-acetylphosphoglucosamine mutase as an antifungal target.

    abstract::Aspergillus fumigatus is the causative agent of IA (invasive aspergillosis) in immunocompromised patients. It possesses a cell wall composed of chitin, glucan and galactomannan, polymeric carbohydrates synthesized by processive glycosyltransferases from intracellular sugar nucleotide donors. Here we demonstrate that A...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Fang W,Du T,Raimi OG,Hurtado-Guerrero R,Mariño K,Ibrahim AF,Albarbarawi O,Ferguson MA,Jin C,Van Aalten DM

    更新日期:2013-09-04 00:00:00

  • Oxytocin contracts the human uterus at term by inhibiting the myometrial Ca2+-extrusion pump.

    abstract::The sarcolemma of smooth-muscle cells from human pregnant myometrium possesses a high-affinity Ca2+-ATPase, which has the characteristics of an active Ca2+-extrusion pump. This pump enzyme, either membrane-bound or solubilized, was strongly inhibited by oxytocin (half-maximal inhibition at about 4 microU/ml or 10 pM)....

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Popescu LM,Nutu O,Panoiu C

    更新日期:1985-01-01 00:00:00

  • LncRNA PACER is down-regulated in osteoarthritis and regulates chondrocyte apoptosis and lncRNA HOTAIR expression.

    abstract::LncRNA PACER is a chondrocyte inflammation-associated long non-coding RNA (lncRNA), and chondrocyte inflammation is involved in osteoarthritis (OA). We observed that plasma PACER was down-regulated, while plasma HOTAIR was up-regulated in OA patients. Altered plasma levels of PACER and HOTAIR distinguished OA patients...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Jiang M,Liu J,Luo T,Chen Q,Lu M,Meng D

    更新日期:2019-06-07 00:00:00

  • The relationship between secretion and intracellular free calcium in bovine adrenal chromaffin cells.

    abstract::The effect of carbamylcholine and the calcium ionophore A23187 on catecholamine release and intracellular free calcium, [Ca2+]i, in bovine adrenal chromaffin cells was determined. At 10(-4) M carbamylcholine maximal release occurred with an accompanying increase in [Ca2+]i from a basal level of 168 nM to less than 300...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Burgoyne RD

    更新日期:1984-07-01 00:00:00

  • IL-38 restrains inflammatory response of collagen-induced arthritis in rats via SIRT1/HIF-1α signaling pathway.

    abstract:OBJECTIVE:To observe the restraining effect of IL-38 on inflammatory response in collagen-induced arthritis rats (CIA), and to explore the regulatory mechanism of SIRT1/HIF-1α signaling pathway. METHODS:40 SD rats were randomly divided into Control group, CIA group, CLL group and CLH group, with 10 rats in each group;...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Pei B,Chen K,Zhou S,Min D,Xiao W

    更新日期:2020-05-29 00:00:00

  • Nucleus pulposus cell apoptosis is attenuated by CDMP-2 through regulating oxidative damage under the hyperosmotic environment.

    abstract::Disc nucleus pulposus (NP) cell experiences periodic osmolarity alterations during daily activities, which has been proved to affect cell biology in vitro The present study was aimed to investigate the effects of cartilage-derived morphogenetic protein-2 (CDMP-2) on NP cell apoptosis under the hyperosmolarity culture ...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Jiao S,Li J,Liu B,Yang M,Xiu J,Qu D

    更新日期:2018-10-09 00:00:00

  • Knocking down of LINC01220 inhibits proliferation and induces apoptosis of endometrial carcinoma through silencing MAPK11.

    abstract::Background: Endometrial carcinoma (EC) still threatens the health of women. Thus, to explore how long intergenic non-protein coding RNA 01220 regulates the development of EC.Methods: Whole genome expression profile data of EC and paracancerous tissues in TCGA database were downloaded. LINC01220 expression in EC and pa...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Li Y,Kong C,Wu C,Wang Y,Xu B,Liang S,Ying X

    更新日期:2019-07-25 00:00:00

  • Age at last birth and risk of developing epithelial ovarian cancer: a meta-analysis.

    abstract::Background: Many epidemiologic studies have explored the association between age at last birth (ALB) and the risk of epithelial ovarian cancer, but the results remain controversial. Methods: A literature search was performed in PubMed, Web of Science, China National Knowledge Infrastructure (CNKI) and WanFang Med Onli...

    journal_title:Bioscience reports

    pub_type: 杂志文章,meta分析


    authors: Wu Y,Sun W,Xin X,Wang W,Zhang D

    更新日期:2019-09-13 00:00:00

  • Identification of a Novel Mutation in the ABCA4 Gene in a Chinese Family with Retinitis Pigmentosa Using Exome Sequencing.

    abstract::Retinitis pigmentosa (RP) is a group of hereditary, degenerative retinal disorders characterized by progressive retinal dysfunction, outer retina cell loss, and retinal tissue atrophy. It eventually leads to tunnel vision and legal, or total blindness. Here we aimed to reveal the causal gene and mutation contributing ...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Huang X,Yuan L,Xu H,Zheng W,Cao Y,Yi J,Guo Y,Yang Z,Li Y,Deng H

    更新日期:2018-04-27 00:00:00

  • The role of transmembrane sodium gradient in rabbit ileal smooth muscle: utilization of harmaline.

    abstract::Decreasing extracellular sodium concentration was found to produce a contractile response of rabbit ileal smooth muscle. As the concentration decreases, the amplitude of contraction increases, thus producing a dose-dependent curve. Harmaline, a competitor for sodium, was found to inhibit the sodium gradient-dependent ...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Suleiman MS

    更新日期:1985-08-01 00:00:00

  • The role of gut microbiota in the effects of maternal obesity during pregnancy on offspring metabolism.

    abstract::Obesity is considered a global epidemic. Specifically, obesity during pregnancy programs an increased risk of the offspring developing metabolic disorders in addition to the adverse effects on the mother per se Large numbers of human and animal studies have demonstrated that the gut microbiota plays a pivotal role in ...

    journal_title:Bioscience reports

    pub_type: 杂志文章,评审


    authors: Zhou L,Xiao X

    更新日期:2018-04-13 00:00:00

  • LncRNA NEAT1 promotes glioma cancer progression via regulation of miR-98-5p/BZW1.

    abstract:BACKGROUND:Glioma is the most common malignant tumor in the human central nervous system. Long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) promotes oncogenesis in various tumors. In the present study, we aimed to examine the role of NEAT1 in altering the properties of gliomas. METHODS:Quantitative ...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Li Y,Wang X,Zhao Z,Shang J,Li G,Zhang R

    更新日期:2021-01-04 00:00:00

  • Survival prediction in patients with colon adenocarcinoma via multi-omics data integration using a deep learning algorithm.

    abstract::This study proposed a deep learning (DL) algorithm to predict survival in patients with colon adenocarcinoma (COAD) based on multi-omics integration. The survival-sensitive model was constructed using an autoencoder for DL implementation based on The Cancer Genome Atlas (TCGA) data of patients with COAD. The autoencod...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Lv J,Wang J,Shang X,Liu F,Guo S

    更新日期:2020-12-01 00:00:00

  • Integrative genomics analysis identifies five promising genes implicated in insomnia risk based on multiple omics datasets.

    abstract::In recent decades, many genome-wide association studies on insomnia have reported numerous genes harboring multiple risk variants. Nevertheless, the molecular functions of these risk variants conveying risk to insomnia are still ill-studied. In the present study, we integrated GWAS summary statistics (N=386,533) with ...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Sun H,Zhang J,Ma Y,Liu J

    更新日期:2020-09-30 00:00:00

  • The first EGF domain of coagulation factor IX attenuates cell adhesion and induces apoptosis.

    abstract::Coagulation factor IX (FIX) is an essential plasma protein for blood coagulation. The first epidermal growth factor (EGF) motif of FIX (EGF-F9) has been reported to attenuate cell adhesion to the extracellular matrix (ECM). The purpose of the present study was to determine the effects of this motif on cell adhesion an...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Ishikawa T,Kitano H,Mamiya A,Kokubun S,Hidai C

    更新日期:2016-06-03 00:00:00

  • SLC39A7, regulated by miR-139-5p, induces cell proliferation, migration and inhibits apoptosis in gastric cancer via Akt/mTOR signaling pathway.

    abstract::As a zinc transporter, SLC39A7 (zip7) is vital in intestinal epithelial self-renewal, and recent studies suggested that SLC39A7 was related to cancer progression. Whereas, little is known about the role of SLC39A7 in gastric cancer (GC). In the present study, qRT-PCR analysis demonstrated that SLC39A7 mRNA level was i...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Zhang Y,Bai J,Si W,Yuan S,Li Y,Chen X

    更新日期:2020-02-28 00:00:00

  • Solvation properties of ubiquinone-10 in solvents of different polarity.

    abstract::The solvation properties of ubiquinone-10 and ubiquinol-10 in a wide variety of solvents of polarity varying from alkanes to water are reported. Greatest solubility is observed in solvents of intermediate polarity and particularly where low polarity is combined with a pronounced tendency to interact with the benzoquin...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Ondarroa M,Sharma SK,Quinn PJ

    更新日期:1986-09-01 00:00:00