Abstract:
:Aim: In previous studies, numerous dysregulated long non-coding RNAs (lncRNAs) were identified by RNA-sequencing (RNA-seq). However, the relationship between lncRNA and osteosarcoma remains unclear. In the present study, the function and mechanism of lncRNA BE503655 were investigated. Methods: Transwell, cell cycle and proliferation were used to evaluate the function of lncRNA BE503655. Real-time PCR and Western blotting were used to detect the expression of lncRNA BE503655 and β-catenin. Results: LncRNA BE503655 is overexpressed in human osteosarcoma and osteosarcoma cell lines. Knockdown lncRNA BE503655 suppresses cell proliferation, invasion and migration. High expression of BE503655 was significantly related to Enneking stage, distant metastasis and histological grade. Moreover, we also provided evidences that lncRNA BE503655 played its functions dependent on regulation of Wnt/β-catenin signaling in osteosarcoma. Conclusion: Taken together, we verified the role of lncRNA BE503655 and provided possible mechanism in osteosarcoma. Our study provided new insights into clinical treatment of osteosarcoma and further intervention target.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Huang Q,Shi SY,Ji HB,Xing SXdoi
10.1042/BSR20182200subject
Has Abstractpub_date
2019-07-29 00:00:00issue
7eissn
0144-8463issn
1573-4935pii
BSR20182200journal_volume
39pub_type
杂志文章abstract::Cholera toxin (CT) is composed of a disulfide-linked A1/A2 heterodimer and a ring-like, cell-binding B homopentamer. The catalytic A1 subunit must dissociate from CTA2/CTB5 to manifest its cellular activity. Reduction of the A1/A2 disulfide bond is required for holotoxin disassembly, but reduced CTA1 does not spontane...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181320
更新日期:2018-09-07 00:00:00
abstract::miRNAs have been implicated in processing of cardiac hypoxia/reoxygenation (H/R)-induced injury. Recent studies demonstrated that miR-19a might provide a potential cardioprotective effect on myocardial disease. However, the effect of miR-19a in regulating myocardial ischemic injury has not been previously addressed. T...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20170899
更新日期:2017-12-05 00:00:00
abstract::Emerging evidence are accumulating that long noncoding RNAs (lncRNAs) have recently been identified to participate in various cellular processes. Terminal differentiation induced ncRNA (TINCR) is a newly identified lncRNA with its functional roles not fully elucidated in human malignancy. The current study aims to ide...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20170301
更新日期:2017-07-27 00:00:00
abstract::The present study describes the enzymatic properties and molecular identification of 5'-nucleotidase in soluble and microsomal fractions from rat cardiac ventricles. Using AMP as a substrate, the results showed that the cation and the concentration required for maximal activity in the two fractions was magnesium at a ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20070039
更新日期:2008-10-01 00:00:00
abstract::Mouse Mex3c encodes RNA-binding proteins of variant length through alternative splicing. Its mutation results in multiple defects including growth retardation, perturbed energy balance, and defective antiviral innate immunity. Here we report that Mex3c mutation affects mammary gland development and lactation in female...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20201285
更新日期:2020-12-23 00:00:00
abstract::In the present study, we aimed to examine whether SET domain-containing methyltransferases are up-regulated in different classes of renal cell carcinoma. We immunoblotted against SET domain and quantified the expression of these modular domains. Furthermore, we examined the expression of Rad51, the key protein that co...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20160122
更新日期:2016-06-30 00:00:00
abstract::Significant amounts of somatostatin-like immunoreactivity (SLI) were detected in the extract of a human catecholamine-secreting adrenal medullary tumour. After salt fractionation and reconstitution the major portion of SLI was purified by gel filtration and two HPLC steps; in all three systems it eluted in the positio...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116377
更新日期:1982-03-01 00:00:00
abstract::3D (three-dimensional) cultures are considered to be an effective method for toxicological studies; however, little evidence has been reported whether 3D cultures have an impact on hepatocellular physiology regarding lipid or glucose metabolism. In the present study, we conducted physiological characterization of hepa...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20150034
更新日期:2015-05-07 00:00:00
abstract::Due to poor prognosis of glioblastoma (GBM), there is an urgent need to develop new therapeutic strategies. Besides eliminating GBM tumor cells and stem cells, a novel therapeutic approach aims to target Glioma-associated microglia/macrophages (GAMs). We investigated the molecular profile of GAMs correlated with patie...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20182361
更新日期:2019-06-20 00:00:00
abstract::Understanding cell migration in a 3D microenvironment is essential as most cells encounter complex 3D extracellular matrix (ECM) in vivo Although interactions between cells and ECM have been studied previously on 2D surfaces, cell migration studies in 3D environment are still limited. To investigate cell migration und...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181596
更新日期:2019-02-19 00:00:00
abstract::Reactive oxygen species (ROS) overproduction and renal tubular epithelial cell (TEC) apoptosis are key mechanisms of contrast-induced acute kidney injury (CI-AKI). Mitochondria are the main source of intracellular ROS. In the present study, the characteristics of mitophagy and the effects of rapamycin on contrast-indu...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180876
更新日期:2018-11-20 00:00:00
abstract::Resistance to chemotherapy is one of main obstacles in the treatment of colorectal cancer (CRC). However, the mechanisms are still unclear, and the treatment options are still limited. miR-543 has been indicated to act as an oncogene in some cancers, but its function in regulating chemoresistance has not been consider...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190249
更新日期:2019-03-22 00:00:00
abstract::As a zinc transporter, SLC39A7 (zip7) is vital in intestinal epithelial self-renewal, and recent studies suggested that SLC39A7 was related to cancer progression. Whereas, little is known about the role of SLC39A7 in gastric cancer (GC). In the present study, qRT-PCR analysis demonstrated that SLC39A7 mRNA level was i...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20200041
更新日期:2020-02-28 00:00:00
abstract::Although wasting marmoset syndrome (WMS) is one of the biggest problems facing captive marmoset colonies, the mechanisms underlying its pathogenesis remain unclear. In our clinical experience, it is difficult to cure WMS-affected marmosets with severe hypoalbuminemia. Thus, the mechanisms underlying hypoalbuminemia in...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190562
更新日期:2019-07-08 00:00:00
abstract::Objective: To explore whether aspirin (ASA) enhances the sensitivity of hepatocellular carcinoma (HCC) side population (SP) cells to doxorubicin (Doxo) via miR-491/ATP-binding cassette sub-family G member 2 (ABCG2).Methods: Non-SP and SP cells were isolated from MHCC-97L cell line using flow cytometry analysis and flu...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180854
更新日期:2018-11-09 00:00:00
abstract::Signal transducer and activator of transcription (STAT), a family of latent cytoplasmic transcription factors, are composed of seven identified members (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). STATs are associated with several biological processes such as cell proliferation, invasion, and metastasis in var...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20170650
更新日期:2017-07-16 00:00:00
abstract::Liver cancer is now one of the most lethal and commonest cancers in the world, among which over 90% is hepatocellular carcinoma (HCC). Recent studies have confirmed long non-coding RNAs (lncRNAs) are implicated in carcinogenesis. It has been reported lncRNA LINC00668 serves as an oncogene in several cancers. However, ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20192697
更新日期:2020-05-29 00:00:00
abstract::TRα1 (thyroid hormone receptor α1) is well recognized for its importance in brain development. However, due to the difficulties in predicting TREs (thyroid hormone response elements) in silico and the lack of suitable antibodies against TRα1 for ChIP (chromatin immunoprecipitation), only a few direct TRα1 target genes...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20120124
更新日期:2013-03-13 00:00:00
abstract::We assessed the relationship between the volume of epicardial adipose tissue and long-term outcomes in patients with coronary heart disease (CHD) undergoing percutaneous coronary intervention (PCI). The patients with CHD were followed for at least 2 years after PCI. The epicardial adipose tissue volume (EATV) was meas...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20182278
更新日期:2019-05-07 00:00:00
abstract::Micro-inflammation plays an important role in the pathogenesis of spontaneously hypertensive rat (SHR). In the present study, we investigated the therapeutic potential of resveratrol (RSV), a polyphenol with anti-fibrosis activity in hypertensive renal damage model. In SHR renal damage model, RSV treatment blunted the...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20160035
更新日期:2016-06-03 00:00:00
abstract::Artocarpus incisa (breadfruit) seeds contain three different lectins (Frutalin, Frutapin (FTP) and Frutackin) with distinct carbohydrate specificities. The most abundant lectin is Frutalin, an α-D-galactose-specific carbohydrate-binding glycoprotein with antitumour properties and potential for tumour biomarker discove...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20170969
更新日期:2017-07-21 00:00:00
abstract::Acquired resistance of afatinib is a significant challenge for non-small cell lung cancer (NSCLC) therapy and the mechanisms remain unclear. Aberrant activation of epidermal growth factor receptor (EGFR)-dependent downstream pathways, especially phosphatidylinositol-3-kinases/protein kinase B (PI3K/Akt) signaling path...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181693
更新日期:2018-12-11 00:00:00
abstract::Identified and cloned in 1996 for the first time, G protein-coupled oestrogen receptor (ER) 30 (GPR30/GPER) has been a hot spot in the field of sex hormone research till now. In the present study, we examined the effects of low-dose oestradiol (E2) combined with G15, a specific antagonist of GPR30 on ovariectomy (OVX)...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20150146
更新日期:2015-07-03 00:00:00
abstract::Regulator of G protein signaling (RGS) proteins are GTPase-activating proteins (GAP) for G protein alpha-subunits and are thought to be responsible for rapid deactivation of G protein mediated signaling pathway. In this present study, we demonstrate that PA is the most efficient candidate to inhibit GAP activity of RG...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1023/b:bire.0000007694.71158.02
更新日期:2003-08-01 00:00:00
abstract::For improving Ostwald's viscometry, which is time-consuming and requires a relatively large volume of specimen to determine viscosity, we developed a capillary microviscometric method with an appropriate mathematical model, and have compared this method with Ostwald's method. ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01121952
更新日期:1983-02-01 00:00:00
abstract::miRNAs are non-coding RNA molecules typically 18-22 nucleotides long that can suppress the expression of their target genes. Several laboratories have attempted to identify miRNAs from the pig that are involved in Salmonella infection. These bioinformatics strategies using the newly available genomic sequence are gene...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20160243
更新日期:2016-08-31 00:00:00
abstract::Radiotherapy is the primary treatment option for nasopharyngeal carcinoma (NPC). Local recurrence and metastasis caused by radioresistance become a bottleneck of curative effect for patients with NPC. Currently, serum predictive biomarkers of radioresistance are scare. We enrolled NPC patients, who underwent radiother...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190027
更新日期:2019-05-14 00:00:00
abstract::The high proliferation rate of tumor cells demands high energy and metabolites that are sustained by a high glycolytic flux known as the 'Warburg effect'. The activation and further metabolism of glucose is initiated by hexokinase, a focal point of metabolic regulation. The human hexokinase 2 (HK2) is overexpressed in...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20171666
更新日期:2018-02-21 00:00:00
abstract::Prefoldin subunits (PFDN), primarily known for co-chaperone function associated with cytoskeletal rearrangement, have been found involved in epithelial-mesenchymal transition (EMT) and cancer progression. However, studies focusing on the roles of PFDN in gastric cancer (GC) remain limited. The present study aims to ev...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20192712
更新日期:2020-02-28 00:00:00
abstract::Previous studies demonstrated that the adaptive response to stressors and inflammatory signals involves the activation of the autonomous [corrected] nervous system. Catecholamines have been shown to modulate the activity of various immune effector cells directly via membrane adrenergic receptors. Here, we investigated...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1023/a:1014768909442
更新日期:2001-10-01 00:00:00