Abstract:
:Liver cancer is now one of the most lethal and commonest cancers in the world, among which over 90% is hepatocellular carcinoma (HCC). Recent studies have confirmed long non-coding RNAs (lncRNAs) are implicated in carcinogenesis. It has been reported lncRNA LINC00668 serves as an oncogene in several cancers. However, the mechanism where LINC00668 regulates HCC is still unclear. qRT-PCR analysis was adopted to detect the expression of relative RNAs. Cytoplasmic and nuclear RNA fraction analysis was conducted to verify the underlying molecular mechanism. Cell colony formation was carried out to test cell colony formation ability and transwell assays were performed to testify cell migratory and invaded abilities. Relevant protein expression level was measured by Western blot assay. LINC00668 was significantly up-regulated in HCC tissues and cell lines. LINC00668 knockdown inhibited cell proliferative, migratory and invasion abilities and slowed down the epithelial-mesenchymal transition (EMT) process. Mechanistically, LINC00668 positively modulates the expression of YY1 by competitively binding to miR-532-5p. It was revealed that LINC00668 up-regulation accelerated cell proliferation and motility in HCC and suggested LINC00668 could be a potential therapeutic target for HCC.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Xuan W,Zhou C,You Gdoi
10.1042/BSR20192697subject
Has Abstractpub_date
2020-05-29 00:00:00issue
5eissn
0144-8463issn
1573-4935pii
222578journal_volume
40pub_type
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journal_title:Bioscience reports
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Bioscience reports
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journal_title:Bioscience reports
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pub_type: 临床试验,杂志文章
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01145177
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journal_title:Bioscience reports
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doi:10.1042/BSR20182201
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journal_title:Bioscience reports
pub_type: 杂志文章
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journal_title:Bioscience reports
pub_type: 杂志文章
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journal_title:Bioscience reports
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journal_title:Bioscience reports
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journal_title:Bioscience reports
pub_type: 杂志文章,评审
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journal_title:Bioscience reports
pub_type: 杂志文章,评审
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journal_title:Bioscience reports
pub_type: 杂志文章
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journal_title:Bioscience reports
pub_type: 杂志文章
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journal_title:Bioscience reports
pub_type: 杂志文章
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journal_title:Bioscience reports
pub_type: 杂志文章
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