A novel antimicrobial peptide, Ranatuerin-2PLx, showing therapeutic potential in inhibiting proliferation of cancer cells.


:Antimicrobial peptides are a promising resource for developing novel antibiotic and even anticancer drugs. Here, a 28-mer polypeptide, Ranatuerin-2PLx (R2PLx), was identified from lyophilised skin secretions. The chemically synthetic replicates exhibited moderate and broadspectrum antimicrobial effect against various microorganisms including methicillin-resistant Staphylococcus aureus (MRSA, minimal inhibitory concentration = 256 µM). In addition, R2PLx was found to inhibit the proliferation of several tumour cells, especially showing more potent effect on prostate cancer cell, PC-3. The early cell apoptosis was observed in 6 h by Annexin V-FITC/propidium iodide staining, as well as the activation of Caspase-3 at 5 µM peptide concentration. R2PLx may therefore be promising for developing new therapeutic approach for cancer treatment. Moreover, the artificial deficiency of conserved rana-box loop or net positive charge in C-terminal domain notably reduced the biological activities of the truncated and substituted isoforms, respectively, suggesting for maintaining their biological potency of ranatuerin family requires both cysteine-bridged segment and cationincity within the loop domain in C-terminus.


Biosci Rep


Bioscience reports


Chen X,Zhang L,Ma C,Zhang Y,Xi X,Wang L,Zhou M,Burrows JF,Chen T




Has Abstract


2018-11-09 00:00:00












  • Comparative analysis of the complete mitochondrial genomes of three rockfishes (Scorpaeniformes, Sebastiscus) and insights into the phylogenetic relationships of Sebastidae.

    abstract::Mitochondrial genome is a powerful molecule marker to provide information for phylogenetic relationships and revealing molecular evolution in ichthyological studies. Sebastiscus species, a marine rockfish, are of essential economic value. However, the taxonomic status and phylogenetic relationships of Sebastidae have ...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Jia C,Zhang X,Xu S,Yang T,Yanagimoto T,Gao T

    更新日期:2020-12-23 00:00:00

  • The antibody paradox: trying on a pair of genes.

    abstract::Rodney Porter's separation of antibody molecules into Fab and Fc fragments engendered the notion that a single antibody polypeptide chain might be coded by two or more genes. This concept profoundly influenced the development of molecular immunology over the past 25 years. Our current knowledge of antibody gene organi...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Fleischman JB

    更新日期:1985-10-01 00:00:00

  • Specific panallergen peptide of Sorghum Polcalcin showing IgE response identified based on in silico and in vivo peptide mapping.

    abstract::In India, Sorghum plant allergenicity was reported to be approximately 54.9%. Sorghum bicolor Polcalcin (Sorb PC) was identified as the panallergen but the specificity of this allergen is yet to be characterized. The present study was aimed to characterize the antigenic determinants of Sorb PC that are responsible for...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Bokka CS,Veeramachaneni GK,Thunuguntla VBSC,Manda NK,Bondili JS

    更新日期:2019-11-29 00:00:00

  • Antigen delivery to mucosa-associated lymphoid tissues using liposomes as a carrier.

    abstract::Oral vaccination requires an antigen delivery vehicle to protect the antigen and to enhance translocation of the antigen to the mucosa-associated lymphoid tissue. A variety of antigen delivery vehicles including liposomes have been studied for mucosal immunization. The advantages of liposome formulations are their par...

    journal_title:Bioscience reports

    pub_type: 杂志文章,评审


    authors: Zho F,Neutra MR

    更新日期:2002-04-01 00:00:00

  • The regulatory effect of has-circ-0001146/miR-26a-5p/MNAT1 network on the proliferation and invasion of osteosarcoma.

    abstract::Osteosarcoma is a malignant bone tumour with the lowest survival rates out of all paediatric cancers and is primarily diagnosed in children and adolescents. MNAT1 is a subunit in the cyclin-dependent kinase-activating kinase complex. Abnormal up-regulation of MNAT1 has been associated with the poor prognosis of multip...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Wang J,Ni J,Song D,Ding M,Huang J,Li W,He G

    更新日期:2020-06-26 00:00:00

  • Nucleus pulposus cell apoptosis is attenuated by CDMP-2 through regulating oxidative damage under the hyperosmotic environment.

    abstract::Disc nucleus pulposus (NP) cell experiences periodic osmolarity alterations during daily activities, which has been proved to affect cell biology in vitro The present study was aimed to investigate the effects of cartilage-derived morphogenetic protein-2 (CDMP-2) on NP cell apoptosis under the hyperosmolarity culture ...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Jiao S,Li J,Liu B,Yang M,Xiu J,Qu D

    更新日期:2018-10-09 00:00:00

  • The Effects of Silver Nanoparticles Biosynthesized Using Fig and Olive Extracts on Cutaneous leishmaniasis Induced Inflammation in Female Balb/c Mice.

    abstract::Leishmaniasis is a group of infectious and non-contagious severe parasitic diseases, caused by protozoans of the Leishmania genus. Natural products characterize a rich source of prospective chemical entities for the development of new effective drugs for neglected diseases. Scientific evaluation of medicinal plants ha...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Almayouf MA,El-Khadragy MF,Awad MA,Al-Olayan EM

    更新日期:2020-11-30 00:00:00

  • A half-century of neurotransmitter research: impact on neurology and psychiatry. Nobel lecture.

    abstract::The effect that research on dopamine and other neutro trasmitters has on disciplines like neurology and psychiatry is described. ...

    journal_title:Bioscience reports

    pub_type: 传,历史文章


    authors: Carlsson A

    更新日期:2001-12-01 00:00:00

  • The interplay of phenotype and genotype in Cryptococcus neoformans disease.

    abstract::Cryptococcus neoformans is an opportunistic fungal pathogen that causes life-threatening meningitis primarily in immunocompromised individuals. In order to survive and proliferate during infection, C. neoformans must adapt to a variety of stresses it encounters within the host. Patient outcome depends on the interacti...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Altamirano S,Jackson KM,Nielsen K

    更新日期:2020-10-30 00:00:00

  • Serum thrombospondin-2 is a candidate diagnosis biomarker for early non-small-cell lung cancer.

    abstract::Thrombospondin-2 (THBS2) is a secreted protein overexpressed in numerous cancers and may function as a diagnostic tumor marker. The objective of the present study was to investigate the diagnostic performance of serum THBS2 in early stage non-small-cell lung cancer (NSCLC). Serum THBS2 and Cyfra21-1 level were evaluat...

    journal_title:Bioscience reports

    pub_type: 临床试验,杂志文章


    authors: Jiang YM,Yu DL,Hou GX,Jiang JL,Zhou Q,Xu XF

    更新日期:2019-07-25 00:00:00

  • Increased expression of SET domain-containing proteins and decreased expression of Rad51 in different classes of renal cell carcinoma.

    abstract::In the present study, we aimed to examine whether SET domain-containing methyltransferases are up-regulated in different classes of renal cell carcinoma. We immunoblotted against SET domain and quantified the expression of these modular domains. Furthermore, we examined the expression of Rad51, the key protein that co...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Liu S,Li Y,Xu H,Wang K,Li N,Li J,Sun T,Xu Y

    更新日期:2016-06-30 00:00:00

  • Real-time measurement of intracellular reactive oxygen species using Mito tracker orange (CMH2TMRos).

    abstract::We have investigated a novel method to monitor real changes of intracellular ROS by the use of CMH2TMRos (a reduced form of MitoTracker orange) in Swiss 3T3 fibroblasts. Arachidonic acid induced a rapid increase of CMTMRos fluorescence with a maximal elevation at 120-150 sec, which was determined by scanning every 10 ...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Kweon SM,Kim HJ,Lee ZW,Kim SJ,Kim SI,Paik SG,Ha KS

    更新日期:2001-06-01 00:00:00

  • Pollen grains bind to lung alveolar type II cells (A549) via lung surfactant protein A (SP-A).

    abstract::Lung surfactant protein A (SP-A) is the most abundant surfactant-associated protein present in the lung. A receptor for SP-A has been shown to be present on A549 alveolar type II cells and on other cell types, including alveolar macrophage. The SP-A receptor on A549 cells has been identified as the collection receptor...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Malhotra R,Haurum J,Thiel S,Jensenius JC,Sim RB

    更新日期:1993-04-01 00:00:00

  • Image processing for cryogenic transmission electron microscopy of symmetry-mismatched complexes.

    abstract::Cryogenic transmission electron microscopy (cryo-TEM) is a high-resolution biological imaging method, whereby biological samples, such as purified proteins, macromolecular complexes, viral particles, organelles and cells, are embedded in vitreous ice preserving their native structures. Due to sensitivity of biological...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Huiskonen JT

    更新日期:2018-04-27 00:00:00

  • The enhanced immunological activity of Paulownia tomentosa flower polysaccharide on Newcastle disease vaccine in chicken.

    abstract::The extracts of Paulownia tomentosa (P. tomentosa) exhibit multiple pharmacological activities. In the present study, P. tomentosa flower polysaccharides (PTFP) were extracted by water decoction and ethanol precipitation, and the immunologic modulations of PTFP against Newcastle disease (ND) vaccine was investigated i...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Yang H,Zhang P,Xu X,Chen X,Liu Q,Jiang C

    更新日期:2019-05-03 00:00:00

  • Phosphatidylserine and Phosphatidylethanolamine Regulate the Structure and Function of FVIIaand Its Interaction with Soluble Tissue Factor.

    abstract::Cell membranes have important functions in many steps of the blood coagulation cascade, including the activation of factor X (FX) by the factor VIIa (FVIIa)-tissue factor (TF) complex (extrinsic Xase). FVIIa shares structural similarity with factor IXa (FIXa) and FXa. FIXa and FXa are regulated by binding to phosphati...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Sengupta T,Koklic T,Lentz BR,Majumder R

    更新日期:2021-01-22 00:00:00

  • APC gene 3'UTR SNPs and interactions with environmental factors are correlated with risk of colorectal cancer in Chinese Han population.

    abstract:OBJECTIVE:To study the correlation between adenomatous polyposis coli (APC) gene 3' untranslated region (UTR) single nucleotide polymorphisms (SNPs) and their interactions with environmental factors and the risk of colorectal cancer (CRC) in a Chinese Han population. METHODS:Genotypes of APC gene 3'UTR rs1804197, rs41...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Ying R,Wei Z,Mei Y,Chen S,Zhu L

    更新日期:2020-03-27 00:00:00

  • Association of the independent polymorphisms in CDKN2A with susceptibility of acute lymphoblastic leukemia.

    abstract::Acute lymphoblastic leukemia (ALL) is the most common cancer in children, and alterations in CDKN2A were considered to play an important role on leukemogenesis. Two single nucleotide polymorphisms (SNPs) at CDKN2A locus were identified to impact on ALL susceptibility via genome wide association studies, and followed b...

    journal_title:Bioscience reports

    pub_type: 杂志文章,meta分析,评审


    authors: Zhou X,Liao F,Zhang J,Qin Y,Xu H,Ding Z,Zhang Y,Zhang F

    更新日期:2018-06-27 00:00:00

  • Oxytocin contracts the human uterus at term by inhibiting the myometrial Ca2+-extrusion pump.

    abstract::The sarcolemma of smooth-muscle cells from human pregnant myometrium possesses a high-affinity Ca2+-ATPase, which has the characteristics of an active Ca2+-extrusion pump. This pump enzyme, either membrane-bound or solubilized, was strongly inhibited by oxytocin (half-maximal inhibition at about 4 microU/ml or 10 pM)....

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Popescu LM,Nutu O,Panoiu C

    更新日期:1985-01-01 00:00:00

  • Latent human leukocyte collagenase can be activated by gold thioglucose and gold sodium thiomalate, but not by auranofin.

    abstract::Gold thioglucose and gold sodium thiomalate were shown to be potent activators of latent human leukocyte collagenase. No activation by auranofin was noted. The activation may proceed through the action of gold on the essential sulfhydryl groups of latent enzyme and, thereby, mimick the action of the known organomercur...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Sorsa T,Suomalainen K,Turto H,Lindy S

    更新日期:1987-12-01 00:00:00

  • Comment on Tauriainen et al.: Serum, liver and bile sitosterol and sitostanol in obese patients with and without NAFLD.

    abstract::This short article provides a comment on the recent article by Tauriainen et al. [Bioscience Reports (2018) 38, BSR20171274 https://doi.org/10.1042/BSR20171274]. ...

    journal_title:Bioscience reports

    pub_type: 评论,信件


    authors: Plat J,Baumgartner S,Houben T,Vreugdenhil ACE,Mensink RP,Lütjohann D,Shiri-Sverdlov R

    更新日期:2018-10-31 00:00:00

  • Carnosic acid impedes cell growth and enhances anticancer effects of carmustine and lomustine in melanoma.

    abstract::Carnosic acid (CA), a major polyphenolic diterpene present in Rosmarinus officinalis, has been reported to have multiple functions, including antitumor activity. The MTT assay, BrdU incorporation, wound healing, and colony formation were used to detect melanoma B16F10 cell growth and proliferation. Flow cytometry was ...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Lin KI,Lin CC,Kuo SM,Lai JC,Wang YQ,You HL,Hsu ML,Chen CH,Shiu LY

    更新日期:2018-07-02 00:00:00

  • Differential inductions of phenylalanine ammonia-lyase and chalcone synthase during wounding, salicylic acid treatment, and salinity stress in safflower, Carthamus tinctorius.

    abstract::Safflower (Carthamus tinctorius L.) serves as a reference dicot for investigation of defence mechanisms in Asteraceae due to abundant secondary metabolites and high resistance/tolerance to environmental stresses. In plants, phenylpropanoid and flavonoid pathways are considered as two central defence signalling cascade...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Dehghan S,Sadeghi M,Pöppel A,Fischer R,Lakes-Harlan R,Kavousi HR,Vilcinskas A,Rahnamaeian M

    更新日期:2014-06-25 00:00:00

  • HPO-Shuffle: an associated gene prioritization strategy and its application in drug repurposing for the treatment of canine epilepsy.

    abstract::Epilepsy is a common neurological disorder that affects mammalian species including human beings and dogs. In order to discover novel drugs for the treatment of canine epilepsy, multiomics data were analyzed to identify epilepsy associated genes. In this research, the original ranking of associated genes was obtained ...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Wang S,Meng X,Wang Y,Liu Y,Xia J

    更新日期:2019-09-06 00:00:00

  • Integrin αvβ6 plays a bi-directional regulation role between colon cancer cells and cancer-associated fibroblasts.

    abstract::Tumor microenvironment (TME) is the cellular environment in which tumor exists, and it contributes to tumor formation and progression. The TME is composed of tumor cells, stromal cells, cytokines, and chemotactic factors of which fibroblasts are the main cellular components. In our present study, we found that colorec...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Peng C,Zou X,Xia W,Gao H,Li Z,Liu N,Xu Z,Gao C,He Z,Niu W,Fang R,Biswas S,Agrez M,Zhi X,Niu J

    更新日期:2018-12-07 00:00:00

  • Aspirin enhances the sensitivity of hepatocellular carcinoma side population cells to doxorubicin via miR-491/ABCG2.

    abstract::Objective: To explore whether aspirin (ASA) enhances the sensitivity of hepatocellular carcinoma (HCC) side population (SP) cells to doxorubicin (Doxo) via miR-491/ATP-binding cassette sub-family G member 2 (ABCG2).Methods: Non-SP and SP cells were isolated from MHCC-97L cell line using flow cytometry analysis and flu...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Xie ZY,Liu MS,Zhang C,Cai PC,Xiao ZH,Wang FF

    更新日期:2018-11-09 00:00:00

  • Binding studies of bile acids using the native fluorescence of the tryptophan residue Of Bax protein.

    abstract::Ursodeoxycholic acid (UDCA) and its taurine-conjugate, tauroursodeoxycholic acid (TUDCA), play a unique role in modulating the apoptotic threshold in cells. The mechanism is thought to involve, in part, inhibition of translocation for Bax from the cytosol to mitochondria. Here, we attempted to use the native fluoresce...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Zhang W,Steer CJ,Douglas KT,Rodrigues CM

    更新日期:2006-06-01 00:00:00

  • Hydrogen sulfide attenuates cardiac dysfunction in a rat model of heart failure: a mechanism through cardiac mitochondrial protection.

    abstract::HF (heart failure) after MI (myocardial infarction) is a major cause of morbidity and mortality worldwide. Recent studies have shown that hydrogen sulfide (H2S) has cardioprotective effects. Hence, we aimed to elucidate the potential effects of H2S on HF after MI in rats. The HF model after MI was made by ligating the...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Wang X,Wang Q,Guo W,Zhu YZ

    更新日期:2011-04-01 00:00:00

  • Protein arrays in functional genome research.

    abstract::Whole-genome analyses become more and more necessary for pharmaceutical research. DNA chip hybridizations are an important tool for monitoring gene expression profiles during diseases or medical treatment. However, drug target identification and validation as well as an increasing number of antibodies and other polype...

    journal_title:Bioscience reports

    pub_type: 杂志文章,评审


    authors: Maercker C

    更新日期:2005-02-01 00:00:00

  • Anti-phospholipase C antibodies inhibit the lectin-induced proliferation of human lymphocytes.

    abstract::A novel approach was used to assess the role of phosphoinositide hydrolysis in the mitogenic action of phytohemagglutinin (PHA) or concanavalin A (ConA). The treatment of human peripheral blood leukocytes (PBL) with monospecific antibodies against phospholipase C (PLC) produced a dose-dependent inhibition (up to 100%)...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Moraru II,Manciulea M,Călugăru A,Ghyka G,Popescu LM

    更新日期:1987-09-01 00:00:00