A novel antimicrobial peptide, Ranatuerin-2PLx, showing therapeutic potential in inhibiting proliferation of cancer cells.


:Antimicrobial peptides are a promising resource for developing novel antibiotic and even anticancer drugs. Here, a 28-mer polypeptide, Ranatuerin-2PLx (R2PLx), was identified from lyophilised skin secretions. The chemically synthetic replicates exhibited moderate and broadspectrum antimicrobial effect against various microorganisms including methicillin-resistant Staphylococcus aureus (MRSA, minimal inhibitory concentration = 256 µM). In addition, R2PLx was found to inhibit the proliferation of several tumour cells, especially showing more potent effect on prostate cancer cell, PC-3. The early cell apoptosis was observed in 6 h by Annexin V-FITC/propidium iodide staining, as well as the activation of Caspase-3 at 5 µM peptide concentration. R2PLx may therefore be promising for developing new therapeutic approach for cancer treatment. Moreover, the artificial deficiency of conserved rana-box loop or net positive charge in C-terminal domain notably reduced the biological activities of the truncated and substituted isoforms, respectively, suggesting for maintaining their biological potency of ranatuerin family requires both cysteine-bridged segment and cationincity within the loop domain in C-terminus.


Biosci Rep


Bioscience reports


Chen X,Zhang L,Ma C,Zhang Y,Xi X,Wang L,Zhou M,Burrows JF,Chen T




Has Abstract


2018-11-09 00:00:00












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    abstract::Epidemiological studies have suggested inconclusive associations between 25-hydroxyvitamin D (25(OH)D) and survival in patients with colorectal cancer (CRC). The aim of the present study was to quantitatively assess these associations. PubMed, EMBASE, and Web of Science databases were systematically searched for eligi...

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    pub_type: 杂志文章


    authors: Wu G,Xue M,Zhao Y,Han Y,Zhang S,Zhang J,Li C,Xu J

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  • Predicted the P2RX7rs3751143 Polymorphism Is Associated with Cancer Risk:A Meta-Analysis and Systematic Review.

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    authors: Wang BJ,Chen JY,Guan Y,Liu DC,Cao ZC,Kong J,Wu ZS,Wu WY

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    abstract::Interleukin-21 (IL-21) is a cytokine that plays a crucial role in pathogenesis and activity of the rheumatoid arthritis (RA). Meanwhile, genetic polymorphisms in the IL-21 gene may alter its expression. Previous studies have reported conflicting results assessing the association between the IL-21 rs6822844 G/T polymor...

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    pub_type: 杂志文章


    authors: Yu M,Hou J,Zheng M,Cao Y,Alike Y,Mi Y,Zhu J

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  • LINC00673 rs11655237 C>T confers neuroblastoma susceptibility in Chinese population.

    abstract::Neuroblastoma, which accounts for approximately 10% of all pediatric cancer-related deaths, has become a therapeutic challenge and global burden attributed to poor outcomes and mortality rates of its high-risk form. Previous genome-wide association studies (GWASs) identified the LINC00673 rs11655237 C>T polymorphism t...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Zhang Z,Chang Y,Jia W,Zhang J,Zhang R,Zhu J,Yang T,Xia H,Zou Y,He J

    更新日期:2018-02-08 00:00:00

  • Identification of a Novel Mutation in the ABCA4 Gene in a Chinese Family with Retinitis Pigmentosa Using Exome Sequencing.

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    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Huang X,Yuan L,Xu H,Zheng W,Cao Y,Yi J,Guo Y,Yang Z,Li Y,Deng H

    更新日期:2018-04-27 00:00:00

  • Toxicity profiling of the ethanolic extract of Citrullus lanatus seed in rats: behavioral, biochemical and histopathological aspects.

    abstract::Citrullus lanatus (Cucurbitaceae) is conventionally used for the treatment of urinary tract infection, renal stones, hypertension, diabetes and diarrhoea. Current study evaluates acute and 28 days repeated toxicity ethanolic extract of C. lanatus seed (EECLS) in Wistar rats to measure its safety profile. The single do...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Belemkar S,Shendge PN

    更新日期:2021-01-29 00:00:00

  • Down-regulated microRNA-30b-3p inhibits proliferation, invasion and migration of glioma cells via inactivation of the AKT signaling pathway by up-regulating RECK.

    abstract::microRNAs (miRNAs) have been found to affect various cancers, and expression of numerous miRNAs is revealed in glioma. However, the role of microRNA-30b-3p (miR-30b-3p) in glioma remains elusive. Therefore, the present study aims to explore the specific mechanism by which miR-30b-3p influence the development of glioma...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Jian Y,Xu CH,Li YP,Tang B,Xie SH,Zeng EM

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  • Efficacy of liraglutide in treating type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease.

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    pub_type: 杂志文章


    authors: Tian F,Zheng Z,Zhang D,He S,Shen J

    更新日期:2018-12-21 00:00:00

  • Identification of signalling cascades involved in red blood cell shrinkage and vesiculation.

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    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Kostova EB,Beuger BM,Klei TR,Halonen P,Lieftink C,Beijersbergen R,van den Berg TK,van Bruggen R

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    pub_type: 杂志文章


    authors: Holm J,Hansen SI,Høier-Madsen M

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    pub_type: 杂志文章


    authors: Ohaeri OC

    更新日期:2001-02-01 00:00:00

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    pub_type: 杂志文章


    authors: Chen G,Chen W,Ye M,Tan W,Jia B

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  • LncRNA PACER is down-regulated in osteoarthritis and regulates chondrocyte apoptosis and lncRNA HOTAIR expression.

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    pub_type: 杂志文章


    authors: Jiang M,Liu J,Luo T,Chen Q,Lu M,Meng D

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  • Chicken liver fatty acid synthetase dimer: evidence of asymmetrical structure from iodoacetamide inhibition studies.

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    pub_type: 杂志文章


    authors: Kumar S,Varagiannis E

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    pub_type: 杂志文章


    authors: Guo L,Zheng P,Fan H,Wang H,Xu W,Zhou W

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  • Neuronal and astrocyte dysfunction diverges from embryonic fibroblasts in the Ndufs4fky/fky mouse.

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    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Bird MJ,Wijeyeratne XW,Komen JC,Laskowski A,Ryan MT,Thorburn DR,Frazier AE

    更新日期:2014-11-21 00:00:00

  • Genetic diversity and drug susceptibility patterns of the Mycobacterium tuberculosis complex in Yunnan, China.

    abstract::Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb) which has been threatening global public health for many years. High genetic diversity is dominant feature of Mtb. Increasing cases of multidrug-resistant (MDR) tuberculosis (MDR-TB) is a serious public health problem to TB control i...

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    pub_type: 杂志文章


    authors: Bai R,Chi S,Li X,Dai X,Ji Z,Jian M,Bi Y,Wang F,Ding Z,Luo L,Chen T,Liu A,Bao F

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  • The degradation of airway tight junction protein under acidic conditions is probably mediated by transient receptor potential vanilloid 1 receptor.

    abstract::Acidic airway microenvironment is one of the representative pathophysiological features of chronic inflammatory respiratory diseases. Epithelial barrier function is maintained by TJs (tight junctions), which act as the first physical barrier against the inhaled substances and pathogens of airway. As previous studies d...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Xu R,Li Q,Zhou J,Zhou XD,Perelman JM,Kolosov VP

    更新日期:2013-10-31 00:00:00

  • Antimicrobial peptides from Capsicum chinense fruits: agronomic alternatives against phytopathogenic fungi.

    abstract::In recent years, the antimicrobial activity of peptides isolated from a wide variety of organs from plant species has been reported. However, a few studies have investigated the potential of antimicrobial peptides (AMPs) found in fruits, especially Capsicum chinense (pepper). The present study aimed to purify and char...

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    authors: de Azevedo Dos Santos L,Taveira GB,da Silva MS,da Silva Gebara R,da Silva Pereira L,Perales J,Teixeira-Ferreira A,de Oliveira Mello É,de Oliveira Carvalho A,Rodrigues R,Gomes VM

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  • A new glycation product 'norpronyl-lysine,' and direct characterization of cross linking and other glycation adducts: NMR of model compounds and collagen.

    abstract::NMR is ideal for characterizing non-enzymatic protein glycation, including AGEs (advanced glycation endproducts) underlying tissue pathologies in diabetes and ageing. Ribose, R5P (ribose-5-phosphate) and ADPR (ADP-ribose), could be significant and underinvestigated biological glycating agents especially in chronic inf...

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    authors: Bullock PT,Reid DG,Ying Chow W,Lau WP,Duer MJ

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  • Electrical stability of erythrocytes in the presence of divalent cations.

    abstract::Erythrocytes suspended in a medium of low ionic strength lyse under the effect of an exponential electrical pulse. The percentage of haemolysed cells decreases several-fold in the presence of divalent cations. The protective action of the ions studied increases in the following order: Ca++, Mg++, Zn++. It is assumed t...

    journal_title:Bioscience reports

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    authors: Tomov TC,Tsoneva IC,Doncheva JC

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  • Identification of novel biomarkers involved in pulmonary arterial hypertension based on multiple-microarray analysis.

    abstract::Pulmonary arterial hypertension (PAH) is a life-threatening chronic cardiopulmonary disorder. However, studies providing PAH-related gene expression profiles are scarce. To identify hub genes involved in PAH, we investigate two microarray data sets from gene expression omnibus (GEO). A total of 150 differentially expr...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Ma Y,Chen SS,Feng YY,Wang HL

    更新日期:2020-09-30 00:00:00

  • Association between epicardial adipose tissue and adverse outcomes in coronary heart disease patients with percutaneous coronary intervention.

    abstract::We assessed the relationship between the volume of epicardial adipose tissue and long-term outcomes in patients with coronary heart disease (CHD) undergoing percutaneous coronary intervention (PCI). The patients with CHD were followed for at least 2 years after PCI. The epicardial adipose tissue volume (EATV) was meas...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Lu C,Jia H,Wang Z

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  • The role of gut microbiota in the effects of maternal obesity during pregnancy on offspring metabolism.

    abstract::Obesity is considered a global epidemic. Specifically, obesity during pregnancy programs an increased risk of the offspring developing metabolic disorders in addition to the adverse effects on the mother per se Large numbers of human and animal studies have demonstrated that the gut microbiota plays a pivotal role in ...

    journal_title:Bioscience reports

    pub_type: 杂志文章,评审


    authors: Zhou L,Xiao X

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  • miR-26a prevents neural stem cells from apoptosis via β-catenin signaling pathway in cardiac arrest-induced brain damage.

    abstract::Neural stem cells (NSCs) transplantation is one of the most promising strategies for the treatment of CA-induced brain damage. The transplanted NSCs could differentiate into new neuron and replace the damaged one. However, the poor survival of NSCs in severe hypoxic condition is the limiting step to make the best use ...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Li F,Wei H,Li H,Li X,Hu C,Zhang J,Deng Y,Liao X

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  • Bcl-2 family of proteins: life-or-death switch in mitochondria.

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    journal_title:Bioscience reports

    pub_type: 杂志文章,评审


    authors: Tsujimoto Y

    更新日期:2002-02-01 00:00:00

  • Structural and functional comparison of fumarylacetoacetate domain containing protein 1 in human and mouse.

    abstract::FAH domain containing protein 1 (FAHD1) is a mammalian mitochondrial protein, displaying bifunctionality as acylpyruvate hydrolase (ApH) and oxaloacetate decarboxylase (ODx) activity. We report the crystal structure of mouse FAHD1 and structural mapping of the active site of mouse FAHD1. Despite high structural simila...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Weiss AKH,Naschberger A,Cappuccio E,Metzger C,Mottes L,Holzknecht M,von Velsen J,Bowler MW,Rupp B,Jansen-Dürr P

    更新日期:2020-03-27 00:00:00

  • TINCR expression is associated with unfavorable prognosis in patients with hepatocellular carcinoma.

    abstract::Emerging evidence are accumulating that long noncoding RNAs (lncRNAs) have recently been identified to participate in various cellular processes. Terminal differentiation induced ncRNA (TINCR) is a newly identified lncRNA with its functional roles not fully elucidated in human malignancy. The current study aims to ide...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Tian F,Xu J,Xue F,Guan E,Xu X

    更新日期:2017-07-27 00:00:00

  • Hexachlorocyclohexanes affect the arachidonic acid release from phosphatidylinositol but not from other phospholipid classes in tubular cell cultures.

    abstract::Gamma- and delta-isomers of hexachlorocyclohexane caused marked decreases in the levels of radioactive phospholipids, and increases in the levels of [3H]arachidonate incorporated into free fatty acids in rat renal tubular cells. The increased radioactivity of free fatty acids arises from the decrease of [3H]arachidona...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Puente-Fraga JC,López-Aparicio P,Senar S,Recio MN,Pérez-Albarsanz MA

    更新日期:1995-08-01 00:00:00

  • Modulation of the extracellular matrix patterning of thrombospondins by actin dynamics and thrombospondin oligomer state.

    abstract::Thrombospondins (TSPs) are evolutionarily-conserved, secreted glycoproteins that interact with cell surfaces and extracellular matrix (ECM) and have complex roles in cell interactions. Unlike the structural components of the ECM that form networks or fibrils, TSPs are deposited into ECM as arrays of nanoscale puncta. ...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Hellewell AL,Gong X,Schärich K,Christofidou ED,Adams JC

    更新日期:2015-05-20 00:00:00