Abstract:
:Objective: We aimed to assess the possible relations between serum levels of macrophage migration inhibitory factor (MIF), a central cytokine of the innate immunity and inflammatory response, and benign paroxysmal positional vertigo (BPPV) risk and BPPV recurrence events.Methods: In the present study, 154 patients with BPPV, and 100 age-and sex-matched control subjects were enrolled in the study. All the patients and controls underwent a complete audio-vestibular test battery including the Dix-Hallpike maneuver and supine roll test. In the BPPV group, measurements of MIF levels were repeated 1 month after the vertigo attack. The patients were also divided into the recurrence group and the nonrecurrence group in the 1-year follow-up.Results: The serum levels of MIF in patients with BPPV were higher than in those controls (13.9[interquartile range {IQR}, 8.9-18.4] ng/ml vs. 9.8[7.8-11.8]; P<0.001). As a continuous variable, MIF was associated with increased risk of BPPV (odds ratio [OR] 1.21, 95% confidence interval [CI]: 1.11-1.39; P=0.004) in multiple regression analyses. Recurrent attacks of BPPV were reported in 35 patients, and those patients had higher levels of MIF than those patients were not recurrence (18.0[IQR, 13.6-22.2] ng/ml vs. 12.6[9.3-16.8] ng/ml). In multivariate models comparing the second (Q2), third (Q3) and fourth(Q4) quartiles against the first (Q1) quartile of MIF, levels of MIF in Q4 were associated with recurrent BPPV, and the odds were increased by approximately 305% (OR = 4.05; 95%CI: 1.65-15.44; P=0.009).Conclusions: Elevated MIF is positively correlated with BPPV risk and BPPV recurrence events, requiring further efforts to clarify the exact mechanism.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Cai HB,Duan L,Tian T,Li ZC,Zhao CC,Ge ZMdoi
10.1042/BSR20191831subject
Has Abstractpub_date
2019-08-23 00:00:00issue
8eissn
0144-8463issn
1573-4935pii
BSR20191831journal_volume
39pub_type
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journal_title:Bioscience reports
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1023/a:1010382001654
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pub_type: 杂志文章,评审
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journal_title:Bioscience reports
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doi:10.1042/BSR20180367
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01121569
更新日期:1983-01-01 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181074
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20192061
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journal_title:Bioscience reports
pub_type: 杂志文章
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abstract:AIM:The purpose of the present study was to explore the function and mechanism of tensin 1 (TNS1) in non-small cell lung cancer (NSCLC) progression. METHODS:The expression of TNS1 in NSCLC cells and tissues was assessed by RT-PCR and Western blot. Besides, Kaplan-Meier survival analysis was recruited to explore the as...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20201539
更新日期:2021-01-29 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190142
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20170926
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pub_type: 杂志文章
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180854
更新日期:2018-11-09 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01114829
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journal_title:Bioscience reports
pub_type: 评论,信件
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更新日期:2018-10-31 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181596
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1023/a:1020262811459
更新日期:1999-12-01 00:00:00
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pub_type: 杂志文章,评审
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