3',5'-cyclic-nucleotide-dependent protein kinase of squamous cell carcinoma of the prostate.

abstract：:In plants, the hydroxymethylpyrimidine (HMP) and thiazole precursors of thiamin are synthesized and coupled together to form thiamin in plastids. Mutants unable to form HMP can be rescued by exogenous HMP, implying the presence of HMP transporters in the plasma membrane and plastids. Analysis of bacterial genomes reve...

journal_title：Bioscience reports

authors： Beaudoin GAW,Johnson TS,Hanson AD

更新日期：2018-03-29 00:00:00

abstract：:Radiotherapy is the primary treatment option for nasopharyngeal carcinoma (NPC). Local recurrence and metastasis caused by radioresistance become a bottleneck of curative effect for patients with NPC. Currently, serum predictive biomarkers of radioresistance are scare. We enrolled NPC patients, who underwent radiother...

journal_title：Bioscience reports

authors： Zhang G,Zhang K,Li C,Li Y,Li Z,Li N,Zhou Q,Shen L

更新日期：2019-05-14 00:00:00

abstract：:Interleukin-21 (IL-21) is a cytokine that plays a crucial role in pathogenesis and activity of the rheumatoid arthritis (RA). Meanwhile, genetic polymorphisms in the IL-21 gene may alter its expression. Previous studies have reported conflicting results assessing the association between the IL-21 rs6822844 G/T polymor...

journal_title：Bioscience reports

authors： Yu M,Hou J,Zheng M,Cao Y,Alike Y,Mi Y,Zhu J

更新日期：2020-01-31 00:00:00

abstract：:PU box binding protein (PU.1) is a critical transcription factor involved in many pathological processes. However, its exact role in activation of hepatic stellate cells (HSCs) and liver fibrosis was rarely reported. Here, we found that, in HSCs of PU.1+/- mice, Sirt1 mRNA expression was not changed but Sirt1 protein ...

journal_title：Bioscience reports

authors： Liu Q,Zhang Y,Yang S,Wu Y,Wang J,Yu W,Liu Y

更新日期：2017-12-12 00:00:00

abstract：:Calmodulin-free ghost membranes were prepared from erythrocytes of kwashiorkor children and from healthy children in the same age bracket. In the absence of calmodulin, the specific activity of Mg2+-dependent Ca2+-pumping ATPase (Ca2+ + Mg2+-ATPase) of kwashiorkor membranes was more than 40 percent lower than the spec...

journal_title：Bioscience reports

authors： Olorunsogo OO

更新日期：1989-06-01 00:00:00

abstract：:Erythrocyte membrane is crucial to maintain the stability of erythrocyte structure. The membrane protein on the surface of erythrocyte membrane enables erythrocyte to have plasticity and pass through the microcirculation without being blocked or destroyed. Decreased deformability of erythrocyte membrane protein will l...

journal_title：Bioscience reports

authors： Wang H,Wei HW,Shen HC,Li ZZ,Cheng Y,Duan LS,Yin L,Yu J,Guo JR

更新日期：2020-06-26 00:00:00

abstract：:Native bovine parathyroid hormone (bPTH) was found to be readily cleaved with human leukocyte elastase to yield the fragments bPTH(1-41) and bPTH(42-84). These were then isolated by reverse-phase HPLC and characterised by gas-phase sequencing and amino acid analysis. The biological activities of these fragments were a...

journal_title：Bioscience reports

authors： Barling PM,Lowe C

更新日期：1987-01-01 00:00:00

abstract：:Thrombospondins (TSPs) are evolutionarily-conserved, secreted glycoproteins that interact with cell surfaces and extracellular matrix (ECM) and have complex roles in cell interactions. Unlike the structural components of the ECM that form networks or fibrils, TSPs are deposited into ECM as arrays of nanoscale puncta. ...

journal_title：Bioscience reports

authors： Hellewell AL,Gong X,Schärich K,Christofidou ED,Adams JC

更新日期：2015-05-20 00:00:00

abstract：:Mitochondrial genome is a powerful molecule marker to provide information for phylogenetic relationships and revealing molecular evolution in ichthyological studies. Sebastiscus species, a marine rockfish, are of essential economic value. However, the taxonomic status and phylogenetic relationships of Sebastidae have ...

journal_title：Bioscience reports

authors： Jia C,Zhang X,Xu S,Yang T,Yanagimoto T,Gao T

更新日期：2020-12-23 00:00:00

abstract：:Two mouse monoclonal antibodies against the human complement control protein, Factor H (beta 1H), are described. The antibodies are both IgG - gamma 1 - subclass and are directed against different epitopes on the human Factor H molecule. One of the antibodies, MRC OX 24, increases the cofactor activity of Factor H in ...

journal_title：Bioscience reports

authors： Sim E,Palmer MS,Puklavec M,Sim RB

更新日期：1983-12-01 00:00:00

abstract：:125I-insulin was shown to be internalized in vivo to a discrete population of low-density membranes (ligandosomes), distinct from the +Golgi, endoplasmic reticulum, plasma membrane, and lysosomes. However, analytical subcellular fractionation shows that glutathione-insulin transhydrogenase is localized to the endoplas...

journal_title：Bioscience reports

authors： Chowdhary BK,Smith GD,Mahler R,Peters TJ

更新日期：1983-04-01 00:00:00

abstract：:Although wasting marmoset syndrome (WMS) is one of the biggest problems facing captive marmoset colonies, the mechanisms underlying its pathogenesis remain unclear. In our clinical experience, it is difficult to cure WMS-affected marmosets with severe hypoalbuminemia. Thus, the mechanisms underlying hypoalbuminemia in...

journal_title：Bioscience reports

authors： Niimi K,Morishita H,Usui M,Ito R,Kurata S,Mataga N,Takahashi E

更新日期：2019-07-08 00:00:00

abstract：:Background: Endometrial carcinoma (EC) still threatens the health of women. Thus, to explore how long intergenic non-protein coding RNA 01220 regulates the development of EC.Methods: Whole genome expression profile data of EC and paracancerous tissues in TCGA database were downloaded. LINC01220 expression in EC and pa...

journal_title：Bioscience reports

authors： Li Y,Kong C,Wu C,Wang Y,Xu B,Liang S,Ying X

更新日期：2019-07-25 00:00:00

abstract：:Tumor microenvironment (TME) is the cellular environment in which tumor exists, and it contributes to tumor formation and progression. The TME is composed of tumor cells, stromal cells, cytokines, and chemotactic factors of which fibroblasts are the main cellular components. In our present study, we found that colorec...

journal_title：Bioscience reports

authors： Peng C,Zou X,Xia W,Gao H,Li Z,Liu N,Xu Z,Gao C,He Z,Niu W,Fang R,Biswas S,Agrez M,Zhi X,Niu J

更新日期：2018-12-07 00:00:00

abstract：:Peanut (Arachis hypogaea) seed lectin, PNA is widely used to identify tumor specific antigen (T-antigen), Galbeta1-3GalNAc on the eukaryotic cell surface. The functional amino acid coding region of a cDNA clone, pBSH-PN was PCR amplified and cloned downstream of the polyhedrin promoter in the Autographa californica nu...

journal_title：Bioscience reports

authors： Kumar M,Behera AK,Kumar S,Srinivas VR,Das HR,Surolia A,Das RH

更新日期：1999-06-01 00:00:00

abstract：:Incubation of adult rat cardiac myocytes with increasing glucose concentrations decreased phosphorylation (αThr172) and activity of AMPK (AMP-activated protein kinase). The effect could be demonstrated without measurable changes in adenine nucleotide contents. The glucose effect was additive to the decrease in AMPK ac...

journal_title：Bioscience reports

authors： Tabidi I,Saggerson D

更新日期：2012-06-01 00:00:00

abstract：:Emerging evidence are accumulating that long noncoding RNAs (lncRNAs) have recently been identified to participate in various cellular processes. Terminal differentiation induced ncRNA (TINCR) is a newly identified lncRNA with its functional roles not fully elucidated in human malignancy. The current study aims to ide...

journal_title：Bioscience reports

authors： Tian F,Xu J,Xue F,Guan E,Xu X

更新日期：2017-07-27 00:00:00

abstract：:The family of 5-HT4 receptors comprises 16 putative splice variants. We have previously shown that there are differences in signal transduction of the h5-HT(4a) and h5-HT(4b) receptors. In the present study, the internalization of these two splice variants following receptor stimulation was investigated with confocal ...

journal_title：Bioscience reports

authors： Pindon A,Van Hecke G,Josson K,Van Gompel P,Lesage A,Leysen JE,Jurzak M

更新日期：2004-06-01 00:00:00

abstract：:Accumulating evidence demonstrates that long non-coding RNA (lncRNA) sprouty4-intron transcript 1 (lncRNA SPRY4-IT1) plays a vital role in the development of breast cancer. However, the underlying mechanism has not been eventually illuminated. We aimed to explore the biological activity of lncRNA SPRY4-IT1 in breast c...

journal_title：Bioscience reports

authors： Wu H,Wang Y,Chen T,Li Y,Wang H,Zhang L,Chen S,Wang W,Yang Q,Chen C

更新日期：2018-10-17 00:00:00

abstract：:The emergence of multidrug-resistant (MDR) microbes caused by overuse of antibiotics leads to urgent demands for novel antibiotics exploration. Our recent data showed that Ly2.1-3 (a novel lymphocyte antigen 6 (Ly6) gene cluster) were proteins with cationic nature and rich in cysteine content, that are characteristic ...

journal_title：Bioscience reports

authors： Liu X,Cao X,Wang S,Ji G,Zhang S,Li H

更新日期：2017-01-17 00:00:00

abstract：:The affinity of epigallocatechin gallate (EGCG) for human serum albumin (HSA) was measured in physiological conditions using NMR and isothermal titration calorimetry (ITC). NMR estimated the Ka (self-dissociation constant) of EGCG as 50 mM. NMR showed two binding events: strong (n1=1.8 ± 0.2; Kd1 =19 ± 12 μM) and weak...

journal_title：Bioscience reports

authors： Eaton JD,Williamson MP

更新日期：2017-05-11 00:00:00

abstract：RATIONALE:Houshiheisan (HSHS), a classic prescription in traditional Chinese medicine (TCM), has remarkable efficacy in the treatment of ischemic stroke. OBJECTIVE:To investigate the pro-angiogenic effect and molecular mechanism of HSHS for stroke recovery. METHODS AND RESULTS:The rat permanent middle cerebral artery...

journal_title：Bioscience reports

authors： Xiang Y,Yao X,Wang X,Zhao H,Zou H,Wang L,Zhang QX

更新日期：2019-10-30 00:00:00

abstract：OBJECTIVE:The present study aimed to construct a diagnosis model for the early differentiation of acute radiation pneumonitis (ARP) and infectious pneumonitis based on multiple parameters. METHODS:The present study included data of 152 patients admitted to the Department of Radiochemotherapy, Tangshan People's Hospita...

journal_title：Bioscience reports

authors： Wang Z,Wu Q,Dong L,Fu H,Liu Q

更新日期：2020-04-30 00:00:00

abstract：:This article discusses how changes in luminal calcium concentration affect calcium release rates from triad-enriched sarcoplasmic reticulum vesicles, as well as single channel opening probability of the ryanodine receptor/calcium release channels incorporated in bilayers. The possible participation of calsequestrin, o...

journal_title：Bioscience reports

authors： Hidalgo C,Donoso P

更新日期：1995-10-01 00:00:00

abstract：:The molecular mechanism of the occurrence and development of papillary thyroid carcinoma (PTC) has been widely explored, but has not been completely elucidated. The present study aimed to identify and analyze genes associated with PTC by bioinformatics methods. Two independent datasets were downloaded from Gene Expres...

journal_title：Bioscience reports

authors： Zhang S,Wang Q,Han Q,Han H,Lu P

更新日期：2019-04-02 00:00:00

abstract：:The increase in % phosphorylase a associated with muscle contraction is reversed after a few minutes despite continued contractile activity. The present study was undertaken to determine whether adrenaline can activate phosphorylase after deactivation has occurred during prolonged stimulation of contraction. We found ...

journal_title：Bioscience reports

authors： Rennie MJ,Fell RD,Ivy JL,Holloszy JO

更新日期：1982-05-01 00:00:00

abstract：:Cryptococcus neoformans is an opportunistic fungal pathogen that causes life-threatening meningitis primarily in immunocompromised individuals. In order to survive and proliferate during infection, C. neoformans must adapt to a variety of stresses it encounters within the host. Patient outcome depends on the interacti...

journal_title：Bioscience reports

authors： Altamirano S,Jackson KM,Nielsen K

更新日期：2020-10-30 00:00:00

abstract：:Rat ventral prostate incorporated (1-14C)acetate, (1-14C)palmitate and (1-14C)linoleate into different phospholipids in a time-dependent process. The rate of incorporation into total phospholipids was higher with linoleate (10.0 nmol/g) than with either palmitate (5.8 nmol/g) or acetate (4.7 nmol/g). Predominant label...

journal_title：Bioscience reports

authors： del Hoyo N,Pulido JA,Carretero MT,Pérez-Albarsanz MA

更新日期：1990-02-01 00:00:00

abstract：:Due to poor prognosis of glioblastoma (GBM), there is an urgent need to develop new therapeutic strategies. Besides eliminating GBM tumor cells and stem cells, a novel therapeutic approach aims to target Glioma-associated microglia/macrophages (GAMs). We investigated the molecular profile of GAMs correlated with patie...

journal_title：Bioscience reports

authors： Gjorgjevski M,Hannen R,Carl B,Li Y,Landmann E,Buchholz M,Bartsch JW,Nimsky C

更新日期：2019-06-20 00:00:00

abstract：:Mycoplasma pneumoniae is one of the most common pathogenic causes of community-acquired pneumonia. Hydrogen sulfide, alanine, and pyruvate producing enzyme (HapE) is a recently discovered M. pneumoniae virulence factor that can produce H2S to promote erythrocyte lysis. However, other cytotoxic effects of HapE have not...

journal_title：Bioscience reports

authors： Li S,Xue G,Zhao H,Feng Y,Yan C,Cui J,Sun H

更新日期：2019-01-18 00:00:00