Studies on the subcellular localization and role of glutathione-insulin transhydrogenase in rat liver.

Abstract:

:125I-insulin was shown to be internalized in vivo to a discrete population of low-density membranes (ligandosomes), distinct from the +Golgi, endoplasmic reticulum, plasma membrane, and lysosomes. However, analytical subcellular fractionation shows that glutathione-insulin transhydrogenase is localized to the endoplasmic reticulum. Measurement of the specific enzyme activity of glutathione-insulin transhydrogenase showed no differences between normal, diabetic, and hyperinsulinaemic rats. These results suggest that glutathione-insulin transhydrogenase is not directly involved in the subcellular processing of receptor-bound internalized insulin.

journal_name

Biosci Rep

journal_title

Bioscience reports

authors

Chowdhary BK,Smith GD,Mahler R,Peters TJ

doi

10.1007/BF01122896

subject

Has Abstract

pub_date

1983-04-01 00:00:00

pages

323-9

issue

4

eissn

0144-8463

issn

1573-4935

journal_volume

3

pub_type

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