Abstract:
:Erythrocyte membrane is crucial to maintain the stability of erythrocyte structure. The membrane protein on the surface of erythrocyte membrane enables erythrocyte to have plasticity and pass through the microcirculation without being blocked or destroyed. Decreased deformability of erythrocyte membrane protein will lead to a series of pathological and physiological changes such as tissue and organ ischemia and hypoxia. Therefore, this research collected 30 cases of healthy blood donors, and explored erythrocyte stored at different times relating indicators including effective oxygen uptake (Q), P50, 2,3-DPG, Na+-k+-ATP. Erythrocyte morphology was observed by electron microscopy. Western blot and immunofluorescence assay were used to detect membrane protein EPB41, S1P, GLTP, SPPL2A expression changes of erythrocyte. To explore the effective carry oxygen capacity of erythrocyte at different storage time resulting in the expression change of erythrocyte surface membrane protein.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Wang H,Wei HW,Shen HC,Li ZZ,Cheng Y,Duan LS,Yin L,Yu J,Guo JRdoi
10.1042/BSR20200799subject
Has Abstractpub_date
2020-06-26 00:00:00issue
6eissn
0144-8463issn
1573-4935pii
225182journal_volume
40pub_type
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