The predictive value of serum lipids for eye metastases in male nasopharyngeal carcinoma patients.

Abstract:

BACKGROUND:Nasopharyngeal carcinoma (NPC) is a tumor that is commonly found in southern China. NPC has several risk factors, such as infection with the Epstein-Barr virus. However, we know little about the risk factors for eye metastasis (EM) in male patients with NPC. Serum lipids are well recognized as risk factors for cardiovascular disease, and recent studies show that they also have a relationship with the development of NPC. PURPOSE:We designed the present study to determine whether they were relevant with the development of EM in male NPC patients by detecting the levels of several serum lipids. METHODS:A total of 1140 male patients with NPC were enrolled in this retrospective study and we divided them into two groups: the metastasis (EM) group and non-eye metastasis (NEM) group. A variety of serum lipids between the two groups were tested and compared. RESULTS:There were statistical differences in the levels of serum TG and TC between these two groups. Binary logistic regression showed that TG and TC were independent risk factors for EM in male NPC patients with P=0.004 and P<0.001, respectively. The area under the curve of TG and TC were 0.764 and 0.681, respectively, using cutoff values of 0.975 and 3.425 mmol/l, respectively. We found that TG had higher sensitivity and specificity values with 87.5% and 62.7%, respectively, than TC which were 50.0% and 87.2%. CONCLUSION:TG and TC are potential risk factors for eye metastases in male NPC patients.

journal_name

Biosci Rep

journal_title

Bioscience reports

authors

Xie Z,Shao Y

doi

10.1042/BSR20201082

subject

Has Abstract

pub_date

2020-06-26 00:00:00

issue

6

eissn

0144-8463

issn

1573-4935

pii

225325

journal_volume

40

pub_type

杂志文章
  • Improved technique for investigation of cell metabolism by 31P NMR spectroscopy.

    abstract::31P NMR studies on microorganisms have been carried out with the cells embedded in agarose gel. The novel use of the gel for the NMR studies has advantages over the usual liquid suspensions in terms of improved reproducibility of data and cell viability, with no net loss of spectral quality. Polyphosphate formation in...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1007/BF01117011

    authors: Jacobson L,Cohen JS

    更新日期:1981-02-01 00:00:00

  • Phagocytosis and phagosome maturation are regulated by calcium in J774 macrophages interacting with unopsonized prey.

    abstract::Phagocytosis by neutrophils, macrophages, and other professional phagocytes requires rapid remodeling of actin. Early phagosomes are surrounded by a rim of F-actin that is disassembled during phagosomoal maturation. Breakdown of periphagosomal F-actin and phagolysosome fusion are calcium dependent processes in neutrop...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1023/a:1022025903688

    authors: Tejle K,Magnusson KE,Rasmusson B

    更新日期:2002-10-01 00:00:00

  • Long non-coding RNA H19 promotes corneal neovascularization by targeting microRNA-29c.

    abstract::Long non-coding RNA (lncRNA) H19 has been implicated in tumor angiogenesis. However, whether H19 regulates the progression of corneal neovascularization (CNV) is unclear. The present study aimed to determine the function of H19 in CNV and its possible molecular mechanism. Here, we found that the H19 levels were remark...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20182394

    authors: Sun B,Ding Y,Jin X,Xu S,Zhang H

    更新日期:2019-05-02 00:00:00

  • Internalization of human 5-HT4a and 5-HT4b receptors is splice variant dependent.

    abstract::The family of 5-HT4 receptors comprises 16 putative splice variants. We have previously shown that there are differences in signal transduction of the h5-HT(4a) and h5-HT(4b) receptors. In the present study, the internalization of these two splice variants following receptor stimulation was investigated with confocal ...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1007/s10540-005-2582-5

    authors: Pindon A,Van Hecke G,Josson K,Van Gompel P,Lesage A,Leysen JE,Jurzak M

    更新日期:2004-06-01 00:00:00

  • Methylenetetrahydrofolate reductase gene polymorphisms in the risk of polycystic ovary syndrome and ovarian cancer.

    abstract::Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) in hormone metabolism pathways might cause metabolic disturbances and contribute to the development of polycystic ovary syndrome (PCOS) and ovarian cancer, but the published studies were inconsistent. The aim of the present study was to evaluate the MTHFR C6...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20200995

    authors: Xiong Y,Bian C,Lin X,Wang X,Xu K,Zhao X

    更新日期:2020-07-31 00:00:00

  • Canstatin induces apoptosis in gastric cancer xenograft growth in mice through the mitochondrial apoptotic pathway.

    abstract::Canstatin, the non-collagenous domain of collagen type IV α-chains, belongs to a series of collagen-derived angiogenic inhibitors. In this study, the inhibitory effect of recombinant canstatin on tumour growth was investigated using a gastric cancer xenograft model. The volume and weight of tumours in mice treated wit...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20140012

    authors: Xing YN,Deng P,Xu HM

    更新日期:2014-04-01 00:00:00

  • LncRNA HOXA-AS2 promotes the progression of prostate cancer via targeting miR-509-3p/PBX3 axis.

    abstract::Long non-coding RNAs (lncRNAs) act as crucial modulators during the development of diverse cancers. Although various types of lncRNAs in prostate cancer (PCa) have been explored, quantities of lncRNAs still wait to be exploited. The present study is to probe the functions and mechanism of lncRNA HOXA cluster antisense...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20193287

    authors: Xiao S,Song B

    更新日期:2020-08-28 00:00:00

  • Characterization of the somatostatin-like immunoreactivity extracted from an adrenal medullary tumour.

    abstract::Significant amounts of somatostatin-like immunoreactivity (SLI) were detected in the extract of a human catecholamine-secreting adrenal medullary tumour. After salt fractionation and reconstitution the major portion of SLI was purified by gel filtration and two HPLC steps; in all three systems it eluted in the positio...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1007/BF01116377

    authors: Corder R,Sykes JE,Lowry PJ

    更新日期:1982-03-01 00:00:00

  • Degradation of side-chains of N-(2-hydroxypropyl)methacrylamide copolymers by lysosomal thiol-proteinases.

    abstract::N-(2-Hydroxypropyl)methacrylamide copolymers bearing oligopeptide side-chains terminating in p-nitroaniline (NAp) were incubated with rat liver lysosomal enzymes in the presence of the thiol glutathione, and the rate of p-nitroaniline release was measured. Twelve of the 16 side-chains investigated were hydrolysed to r...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1007/BF01122173

    authors: Duncan R,Cable HC,Lloyd JB,Rejmanová P,Kopecek J

    更新日期:1982-12-01 00:00:00

  • Development and validation of nomogram to predict risk of survival in patients with laryngeal squamous cell carcinoma.

    abstract::To the best of our knowledge, this is the first study established a nomogram to predict survival probability in Asian patients with LSCC. A risk prediction nomogram for patients with LSCC, incorporating easily assessable clinicopathologic factors, generates more precise estimations of the survival probability when com...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20200228

    authors: Cui J,Wang L,Zhong W,Chen Z,Tan X,Yang H,Chen J,Liu G

    更新日期:2020-08-28 00:00:00

  • Association between serum copper levels and cervical cancer risk: a meta-analysis.

    abstract::Whether serum copper levels were higher in patients with cervical cancer than that in controls was controversial. Hence, we conducted the present study to explore the relationship between serum copper levels and cervical cancer. We searched PubMed, WanFang, and China National Knowledge Internet (CNKI) for relevant stu...

    journal_title:Bioscience reports

    pub_type: 杂志文章,meta分析

    doi:10.1042/BSR20180161

    authors: Zhang M,Shi M,Zhao Y

    更新日期:2018-07-06 00:00:00

  • Frutapin, a lectin from Artocarpus incisa (breadfruit): cloning, expression and molecular insights.

    abstract::Artocarpus incisa (breadfruit) seeds contain three different lectins (Frutalin, Frutapin (FTP) and Frutackin) with distinct carbohydrate specificities. The most abundant lectin is Frutalin, an α-D-galactose-specific carbohydrate-binding glycoprotein with antitumour properties and potential for tumour biomarker discove...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20170969

    authors: de Sousa FD,da Silva BB,Furtado GP,Carneiro IS,Lobo MDP,Guan Y,Guo J,Coker AR,Lourenzoni MR,Guedes MIF,Owen JS,Abraham DJ,Monteiro-Moreira ACO,Moreira RA

    更新日期:2017-07-21 00:00:00

  • Genetic diversity and drug susceptibility patterns of the Mycobacterium tuberculosis complex in Yunnan, China.

    abstract::Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb) which has been threatening global public health for many years. High genetic diversity is dominant feature of Mtb. Increasing cases of multidrug-resistant (MDR) tuberculosis (MDR-TB) is a serious public health problem to TB control i...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20181746

    authors: Bai R,Chi S,Li X,Dai X,Ji Z,Jian M,Bi Y,Wang F,Ding Z,Luo L,Chen T,Liu A,Bao F

    更新日期:2019-05-31 00:00:00

  • Increase of glandular epithelial cell clusters by an external volume expansion device promotes adipose tissue regeneration by recruiting macrophages.

    abstract::Background: There is a clinical need for the use of engineered adipose tissue in place of surgical reconstruction. We previously found that the external volume expansion (EVE) device increased special cell clusters in well-vascularized connective stroma during adipose regeneration. However, the origin of these cell cl...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20181776

    authors: Chen X,He Y,Xu A,Deng Z,Feng J,Lu F,Yuan Y

    更新日期:2019-02-26 00:00:00

  • Biosynthetic capacity of hepatocytes after storage at 4 degrees C.

    abstract::Capacity to synthesize glucose, urea, and ketone bodies is well maintained in hepatocytes after storage for at least 24 h at 4 degrees C. Substrates and albumin are the only requirements. ...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1007/BF01120697

    authors: Farrell R,Lund P

    更新日期:1983-06-01 00:00:00

  • Mutations in LAMA2 and CAPN3 genes associated with genetic and phenotypic heterogeneities within a single consanguineous family involving both congenital and progressive muscular dystrophies.

    abstract::LGMD (limb-girdle muscular dystrophy) and CMD (congenital muscular dystrophy) are two common forms of neuromuscular disorders which are distinguishable by their age of onset but with probably a similar underlying pathway. In the present study, we report immunohistochemical, Western-blot and genetic analyses in a large...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20100026

    authors: Hadj Salem I,Kamoun F,Louhichi N,Rouis S,Mziou M,Fendri-Kriaa N,Makni-Ayadi F,Triki C,Fakhfakh F

    更新日期:2011-04-01 00:00:00

  • Identification of key genes involved in type 2 diabetic islet dysfunction: a bioinformatics study.

    abstract::Aims: To identify the key differentially expressed genes (DEGs) in islet and investigate their potential pathway in the molecular process of type 2 diabetes.Methods: Gene Expression Omnibus (GEO) datasets (GSE20966, GSE25724, GSE38642) of type 2 diabetes patients and normal controls were downloaded from GEO database. ...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20182172

    authors: Zhong M,Wu Y,Ou W,Huang L,Yang L

    更新日期:2019-05-31 00:00:00

  • Up-regulation of KIF14 is a predictor of poor survival and a novel prognostic biomarker of chemoresistance to paclitaxel treatment in cervical cancer.

    abstract::Kinesin family member 14 (KIF14) is a member of kinesin family proteins which have been found to be dysregulated in various cancer types. However, the expression of KIF14 and its potential prognostic significance have not been investigated in cervical cancer. Real-time PCR was performed to assess the expression levels...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20150314

    authors: Wang W,Shi Y,Li J,Cui W,Yang B

    更新日期:2016-04-05 00:00:00

  • A proper transmembrane Ca2+ gradient is essential for the stimulation of adenylate cyclase activity by stimulatory GTP-binding protein.

    abstract::Stimulatory GTP-binding Protein (Gs) and adenylate cyclase prepared from bovine brain cortices were co-reconstituted into asolectin vesicles with or without 1000-fold transmembrane Ca2+ gradient. The results showed that both basal activity and Gs-stimulated activity of adenylate cyclase were highest in proteoliposomes...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1007/BF01200247

    authors: Huang Y,Fan G,Yang F

    更新日期:1994-08-01 00:00:00

  • Immunochemical recognition of phosphate ester derivatives of phenol rings is dependent upon the electronic charge of the ester group.

    abstract::The recognition of phosphate and sulphate esters of tyrosine residues has been studied employing antisera with specificity for tyrosine phosphate, and the enzymes aryl sulphatase, and acid and alkaline phosphatases. The ability of tyrosine phosphate, and of phosphate esters of phenol, to inhibit the antiserum was pH d...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1007/BF01115155

    authors: Jones JA,Wood A,Cushley W

    更新日期:1986-03-01 00:00:00

  • Solvation properties of ubiquinone-10 in solvents of different polarity.

    abstract::The solvation properties of ubiquinone-10 and ubiquinol-10 in a wide variety of solvents of polarity varying from alkanes to water are reported. Greatest solubility is observed in solvents of intermediate polarity and particularly where low polarity is combined with a pronounced tendency to interact with the benzoquin...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1007/BF01117101

    authors: Ondarroa M,Sharma SK,Quinn PJ

    更新日期:1986-09-01 00:00:00

  • Disturbances in T-cell subpopulations in B-cell chronic lymphocytic leukaemia.

    abstract::The relative proportions of immunoregulatory T-cell subpopulations defined by OKT monoclonal antibodies are disturbed in chronic lymphocytic leukaemia (CLL) patients (even early mild cases) compared with normal subjects in the same age range. The mean ratio OKT4+:OKT8+ (helper:suppressor/cytotoxic) is reversed from th...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1007/BF01314213

    authors: Johnstone AP,Height S,Millard RE

    更新日期:1982-08-01 00:00:00

  • Disorders of nuclear-mitochondrial intergenomic communication.

    abstract::In the course of evolution, mitochondria lost their independence, and mtDNA became "slave" of nDNA, depending on numerous nucleus-encoded factors for its integrity, replication and expression. Mutations in any of these factors may alter the cross-talk between the two genomes and cause diseases that affect mtDNA integr...

    journal_title:Bioscience reports

    pub_type: 杂志文章,评审

    doi:10.1007/s10540-007-9036-1

    authors: Spinazzola A,Zeviani M

    更新日期:2007-06-01 00:00:00

  • Discovery of novel isoliquiritigenin analogue ISL-17 as a potential anti-gastric cancer agent.

    abstract::Isoliquiritigenin (ISL), a natural product isolated from licorice root, exhibits anti-gastric cancer effects. However, applications of ISL are still limited in clinical practice due to its poor bioavailability. To discovery of more effective anti-gastric cancer agents based on ISL, aldol condensation reaction was appl...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20201199

    authors: Huang F,Wang J,Xu Y,Zhang Y,Xu N,Yin L

    更新日期:2020-06-26 00:00:00

  • Emodin protects against intestinal and lung injury induced by acute intestinal injury by modulating SP-A and TLR4/NF-κB pathway.

    abstract:OBJECTIVE:Our aim was to investigate the effect of emodin on intestinal and lung injury induced by acute intestinal injury in rats and explore potential molecular mechanisms. METHODS:Healthy male Sprague-Dawley (SD) rats were randomly divided into five groups (n=10, each group): normal group; saline group; acute intes...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20201605

    authors: Qian J,Li G,Jin X,Ma C,Cai W,Jiang N,Zheng J

    更新日期:2020-09-30 00:00:00

  • Variants and expression changes in PPAR-encoding genes display no significant association with schizophrenia.

    abstract::A few studies suggested the contribution of PPARs to the etiology of schizophrenia (SCZ). However, it is still not clear whether variants in PPAR-encoding genes have a direct association with SCZ. The potential linkage between SCZ and the variants within PPAR encoding genes (PPARA, PPARD, and PPARG) was tested in a la...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20201083

    authors: Li X,Zhu Y,Keaton M,Baranova A,Liu S,Hu X,Li Q,Cheng L,Zhou P,Cao H,Xu Y

    更新日期:2020-07-31 00:00:00

  • The N-terminal polypeptide derived from vMIP-II exerts its anti-tumor activity in human breast cancer by regulating lncRNA SPRY4-IT1.

    abstract::Accumulating evidence demonstrates that long non-coding RNA (lncRNA) sprouty4-intron transcript 1 (lncRNA SPRY4-IT1) plays a vital role in the development of breast cancer. However, the underlying mechanism has not been eventually illuminated. We aimed to explore the biological activity of lncRNA SPRY4-IT1 in breast c...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20180411

    authors: Wu H,Wang Y,Chen T,Li Y,Wang H,Zhang L,Chen S,Wang W,Yang Q,Chen C

    更新日期:2018-10-17 00:00:00

  • Amino acid sequence and structural repeats in schistosome paramyosin match those of myosin.

    abstract::The cDNA encoding about half of an antigenic non-surface schistosome parasite protein of Mr 97 K has recently been cloned and sequenced (Lanar, Pearce, James and Sher (1986) Science 234:593-596). Analysis of this sequence, together with the properties of the native protein, reveals that this protein is paramyosin, the...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1007/BF01122722

    authors: Cohen C,Lanar DE,Parry DA

    更新日期:1987-01-01 00:00:00

  • Extraction of the anti-sepsis component from Terminaliachebula Retz and evaluation of its biological activities.

    abstract::Many clinical experiments and studies have demonstrated that traditional Chinese medicines possess the capacity for being used in anti-sepsis. In this paper, we screened 78 herbs based on biosensor technology by targeting of lipid A. Terminaliachebula Retz was found to possess the highest capability of binding lipid A...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20080158

    authors: Yao J,Zheng JS,Fu W,Zheng J

    更新日期:2009-10-06 00:00:00

  • Whole genome survey analysis and microsatellite motif identification of Sebastiscus marmoratus.

    abstract::The marbled rockfish Sebastiscus marmoratus is an ecologically and economically important marine fish species distributed along the northwestern Pacific coast from Japan to the Philippines. Here, next-generation sequencing was used to generate a whole genome survey dataset to provide fundamental information of its gen...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20192252

    authors: Xu SY,Song N,Xiao SJ,Gao TX

    更新日期:2020-02-28 00:00:00