Oxytocin contracts the human uterus at term by inhibiting the myometrial Ca2+-extrusion pump.

Abstract:

:The sarcolemma of smooth-muscle cells from human pregnant myometrium possesses a high-affinity Ca2+-ATPase, which has the characteristics of an active Ca2+-extrusion pump. This pump enzyme, either membrane-bound or solubilized, was strongly inhibited by oxytocin (half-maximal inhibition at about 4 microU/ml or 10 pM). However, under similar conditions, oxytocin did not inhibit Ca2+-extrusion ATPase of the erythrocyte membrane. The inhibitory concentrations of oxytocin correspond to hormone plasma levels which initiate spontaneous labor.

journal_name

Biosci Rep

journal_title

Bioscience reports

authors

Popescu LM,Nutu O,Panoiu C

doi

10.1007/BF01117437

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

21-8

issue

1

eissn

0144-8463

issn

1573-4935

journal_volume

5

pub_type

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