Abstract:
:Incubation of mouse thymocytes with 10 microM monensin for 1 hour induces morphological alterations characterized by the extensive dilatation and vacuolization of the Golgi complex. This effect is used to study the transport and utilization of labelled sugar nucleotides into intracellular vesicles by using thymocytes whose plasma membrane has been permeabilized by ammonium chloride treatment. It is demonstrated that monensin stimulates the incorporation of labelled sialyl, fucosyl, galactosyl, and N-acetylglucosaminyl residues. This enhanced incorporation is not due to a direct effect of monensin on glycosyltransferase activities themselves but is a consequence of a higher entry and accumulation of labelled sugar nucleotides in the dilated vesicles.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Cecchelli R,Cacan R,Porchet-Hennere E,Verbert Adoi
10.1007/BF01115011subject
Has Abstractpub_date
1986-02-01 00:00:00pages
227-34issue
2eissn
0144-8463issn
1573-4935journal_volume
6pub_type
杂志文章abstract:BACKGROUND:Glioblastoma (GBM) is the most common malignant brain tumor with a poor prognosis. The initial treatment for high-grade gliomas is surgical excision. However, even with concomitant use of radiation or chemotherapy, patients are still prone to recurrence. The specific pathogenesis of GBM is still controversia...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20201401
更新日期:2020-06-26 00:00:00
abstract::Objective: We aimed to assess the possible relations between serum levels of macrophage migration inhibitory factor (MIF), a central cytokine of the innate immunity and inflammatory response, and benign paroxysmal positional vertigo (BPPV) risk and BPPV recurrence events.Methods: In the present study, 154 patients wit...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20191831
更新日期:2019-08-23 00:00:00
abstract:BACKGROUND:Lung adenocarcinoma (LUAD) is the most frequent histological type of lung cancer, and its incidence has displayed an upward trend in recent years. Nevertheless, little is known regarding effective biomarkers for LUAD. METHODS:The robust rank aggregation method was used to mine differentially expressed genes...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20203973
更新日期:2021-01-29 00:00:00
abstract::FAH domain containing protein 1 (FAHD1) is a mammalian mitochondrial protein, displaying bifunctionality as acylpyruvate hydrolase (ApH) and oxaloacetate decarboxylase (ODx) activity. We report the crystal structure of mouse FAHD1 and structural mapping of the active site of mouse FAHD1. Despite high structural simila...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20194431
更新日期:2020-03-27 00:00:00
abstract::A model explaining quantal Ca2+ release as an intrinsic property of the inositol 1,4,5-triphosphate (IP3) receptor has been put forward. The model is based on the hypothesis that the IP3 receptor can catalyze a transformation of the IP3 molecule differing from its conventional metabolism. A simple kinetic mechanism is...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01207265
更新日期:1996-10-01 00:00:00
abstract::Fungal endophytes are known to secrete a large array of secondary metabolites (phenols, flavonoids, indole acetic acid (IAA) etc.) that facilitate crops under stress conditions. Considering this, a potent plant growth promoting endophyte (SXSp1) from the spines and leaves of Solanum xanthocarpum L. has been isolated. ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190290
更新日期:2019-10-30 00:00:00
abstract::Lung surfactant protein A (SP-A) is the most abundant surfactant-associated protein present in the lung. A receptor for SP-A has been shown to be present on A549 alveolar type II cells and on other cell types, including alveolar macrophage. The SP-A receptor on A549 cells has been identified as the collection receptor...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01145960
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:Glioma is the most common malignant tumor in the human central nervous system. Long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) promotes oncogenesis in various tumors. In the present study, we aimed to examine the role of NEAT1 in altering the properties of gliomas. METHODS:Quantitative ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20200767
更新日期:2021-01-04 00:00:00
abstract::We have previously established a rat model of chronic uremia, which is suitable to investigate the effect of various treatment modalities on renal osteodystrophy [1]. After four months subsequent to 5/6 nephrectomy, some animals were treated by gavage for 9 weeks with tap water (controls), or with aluminium (Al-citrat...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01201001
更新日期:1996-02-01 00:00:00
abstract::Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) in hormone metabolism pathways might cause metabolic disturbances and contribute to the development of polycystic ovary syndrome (PCOS) and ovarian cancer, but the published studies were inconsistent. The aim of the present study was to evaluate the MTHFR C6...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20200995
更新日期:2020-07-31 00:00:00
abstract::Extracts from uterine cervical and body cancers, but not from benign tumor or intact tissues tested, were found to contain a growth-promoting activity which induced the proliferation of human endometrial fibroblasts. Exposure of cultured fibroblasts to the cancer extracts increased the rate of [3H]thymidine incorporat...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116850
更新日期:1990-02-01 00:00:00
abstract::Rabbit reticulocyte lysates, gel filtered on Sephadex G-25 with or without ATP (or its analogs), were preincubated at 37 degrees C and their subsequent binding to p3A4,3'-[32P]pCp was studied. Lysates filtered without ATP or in the presence of 0.1 mM 8-bromo-ATP, 1,N6-etheno-ATP, or ITP showed a time-dependent decreas...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01119625
更新日期:1985-12-01 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20130087
更新日期:2013-10-31 00:00:00
abstract::Canstatin, the non-collagenous domain of collagen type IV α-chains, belongs to a series of collagen-derived angiogenic inhibitors. In this study, the inhibitory effect of recombinant canstatin on tumour growth was investigated using a gastric cancer xenograft model. The volume and weight of tumours in mice treated wit...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20140012
更新日期:2014-04-01 00:00:00
abstract::C3G (Crk SH3-domain-binding guanine-nucleotide-releasing factor) is a ubiquitously expressed member of a class of molecules called GEFs (guanine-nucleotide-exchange factor) that activate small GTPases and is involved in pathways triggered by a variety of signals. It is essential for mammalian embryonic development and...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1042/BSR20100094
更新日期:2011-08-01 00:00:00
abstract::N-(2-Hydroxypropyl)methacrylamide copolymers bearing oligopeptide side-chains terminating in p-nitroaniline (NAp) were incubated with rat liver lysosomal enzymes in the presence of the thiol glutathione, and the rate of p-nitroaniline release was measured. Twelve of the 16 side-chains investigated were hydrolysed to r...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01122173
更新日期:1982-12-01 00:00:00
abstract::Maclurin, the potent non-specific blood-group hemagglutinin present in extracts of Maclura pomifera, has been purified by a new biospecific affinity-chromatographic procedure. Additional studies have indicated that this hemagglutinin occurs as five closely related tetrameric protein isoforms derived from two non-coval...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01136724
更新日期:1982-04-01 00:00:00
abstract::Specific binding sites for somatostatin have been found in the cytosolic fractions of both parietal and non-parietal cells from rabbit gastric fundic mucosa. The stoichiometric data suggested the presence of two classes of binding sites in both types of cells. The number of low-affinity binding sites was significantly...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116904
更新日期:1985-04-01 00:00:00
abstract::Cervical carcinoma is the most common gynecological cancer in women worldwide. Emerging evidence has shown that long non-coding RNAs (lncRNAs) participate in multiple biological processes of cervical carcinoma tumorigenesis. We aimed to investigate the function of a novel lncRNA RP11-284F21.9 in cervical carcinoma. We...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20200784
更新日期:2020-09-30 00:00:00
abstract::Evidence is presented in support of a pathway in skeletal muscle of glyconeogenesis (glycogen biosynthesis de novo) from L-glutamate and related amino acids involving the enzyme phosphoenolpyruvate carboxykinase (PEP CK). In the rat hemidiaphragm in vitro, not only did L-[U]-14C]glutamate exert a glycogen-sparing acti...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01117013
更新日期:1981-02-01 00:00:00
abstract::This review covers the recent progress in the elucidation of the structure of photosystem II (PSII). Because much of the structural information for this membrane protein complex has been revealed by electron microscopy (EM), the review will also consider the specific technical and interpretation problems that arise wi...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1007/BF01206204
更新日期:1996-04-01 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20160135
更新日期:2016-09-29 00:00:00
abstract::Whether they are small enough to wriggle through the current-carrying part of an ionic channel or big enough to be kept outside and thus able to exert an osmotic stress on the channel space, polymers interact with channels in several instructive ways. The osmotic stress of excluded polymers allows one to measure the n...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01204353
更新日期:1995-12-01 00:00:00
abstract::Long non-coding RNA (lncRNA) H19 has been implicated in tumor angiogenesis. However, whether H19 regulates the progression of corneal neovascularization (CNV) is unclear. The present study aimed to determine the function of H19 in CNV and its possible molecular mechanism. Here, we found that the H19 levels were remark...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20182394
更新日期:2019-05-02 00:00:00
abstract::Background: Urotensin-II (UII) rs228648 polymorphism has been reported to be associated with the risk of diabetes mellitus (DM) with inconsistent results. The present study sought to reassess the relationship between this polymorphism and susceptibility to DM by meta-analysis.Methods: Relevant eligible studies and who...
journal_title:Bioscience reports
pub_type: 杂志文章,meta分析
doi:10.1042/BSR20181275
更新日期:2018-12-07 00:00:00
abstract::Western blotting was used as a powerful alternative to immunoprecipitation for the detection of the simian virus 40 (SV40) large tumor (T) antigen. After resolution by electrophoresis on a SDS-polyacrylamide gel of a [35S]methionine labeled crude extract from SV40 infected monkey kidney cells, the separated proteins w...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01117060
更新日期:1985-02-01 00:00:00
abstract::As a zinc transporter, SLC39A7 (zip7) is vital in intestinal epithelial self-renewal, and recent studies suggested that SLC39A7 was related to cancer progression. Whereas, little is known about the role of SLC39A7 in gastric cancer (GC). In the present study, qRT-PCR analysis demonstrated that SLC39A7 mRNA level was i...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20200041
更新日期:2020-02-28 00:00:00
abstract::Mycoplasma pneumoniae is one of the most common pathogenic causes of community-acquired pneumonia. Hydrogen sulfide, alanine, and pyruvate producing enzyme (HapE) is a recently discovered M. pneumoniae virulence factor that can produce H2S to promote erythrocyte lysis. However, other cytotoxic effects of HapE have not...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20182201
更新日期:2019-01-18 00:00:00
abstract:BACKGROUND:Emerging evidences have indicated that long non-coding RNAs (LncRNAs) play vital roles in cancer development and progression. Previous studies have suggested that overexpression of SPRY4 intronic transcript 1 (SPRY4-IT1) predicates poor prognosis and promotes tumor progress in cervical cancer (CC). However, ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181339
更新日期:2019-06-04 00:00:00
abstract::microRNAs (miRNAs) have been found to affect various cancers, and expression of numerous miRNAs is revealed in glioma. However, the role of microRNA-30b-3p (miR-30b-3p) in glioma remains elusive. Therefore, the present study aims to explore the specific mechanism by which miR-30b-3p influence the development of glioma...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20182226
更新日期:2019-08-13 00:00:00