Identification of thyroid hormone response elements in vivo using mice expressing a tagged thyroid hormone receptor α1.

abstract：:Wilms tumor is the most common pediatric malignancy in the kidney. The miR34b/c is a downstream target gene of the transcription factor p53. The important role of TP53 mutations, the methylation of miR34b/c, and the interaction between these two molecules in tumorigenesis have been well documented. Due to the biologic...

journal_title：Bioscience reports

authors： Wang J,Lou S,Huang X,Mo Y,Wang Z,Zhu J,Tian X,Shi J,Zhou H,He J,Ruan J

更新日期：2020-02-28 00:00:00

abstract：:The effect of carbamylcholine and the calcium ionophore A23187 on catecholamine release and intracellular free calcium, [Ca2+]i, in bovine adrenal chromaffin cells was determined. At 10(-4) M carbamylcholine maximal release occurred with an accompanying increase in [Ca2+]i from a basal level of 168 nM to less than 300...

journal_title：Bioscience reports

authors： Burgoyne RD

更新日期：1984-07-01 00:00:00

abstract：:In plants, the hydroxymethylpyrimidine (HMP) and thiazole precursors of thiamin are synthesized and coupled together to form thiamin in plastids. Mutants unable to form HMP can be rescued by exogenous HMP, implying the presence of HMP transporters in the plasma membrane and plastids. Analysis of bacterial genomes reve...

journal_title：Bioscience reports

authors： Beaudoin GAW,Johnson TS,Hanson AD

更新日期：2018-03-29 00:00:00

abstract：:This study is part of an attempt to understand the role of specific cellular activities in the bone resorptive process. Experiments were performed whereby known pharmacological agents were used to inhibit individual modes of osteoclastic activity, such as motility and secretion. The effects of such treatments on bone ...

journal_title：Bioscience reports

authors： Zaidi M

更新日期：1990-12-01 00:00:00

abstract：:This study proposed a deep learning (DL) algorithm to predict survival in patients with colon adenocarcinoma (COAD) based on multi-omics integration. The survival-sensitive model was constructed using an autoencoder for DL implementation based on The Cancer Genome Atlas (TCGA) data of patients with COAD. The autoencod...

journal_title：Bioscience reports

authors： Lv J,Wang J,Shang X,Liu F,Guo S

更新日期：2020-12-01 00:00:00

abstract：:Common colds were shortened by 7 days in a 1984 clinical trial using zinc gluconate throat lozenges each 2 h. Between then and 2004, 10 other double-blind, placebo-controlled clinical trials showed widely varying results. This re-analysis of these trials presents solution chemistry methods to elucidate differences in ...

journal_title：Bioscience reports

authors： Eby GA

更新日期：2004-02-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is the most common malignancy in the oral cavity, which accounts for >90% of all diagnosed oral cancers. 2-phenylethynesulfonamide (PES) was known as a selective heat shock protein 70 (Hsp70) function inhibitor, which induced cytotoxic effects on various tumor cell types, but showed...

journal_title：Bioscience reports

authors： Jiang L,Xiao J

更新日期：2020-03-27 00:00:00

abstract：:The increase in % phosphorylase a associated with muscle contraction is reversed after a few minutes despite continued contractile activity. The present study was undertaken to determine whether adrenaline can activate phosphorylase after deactivation has occurred during prolonged stimulation of contraction. We found ...

journal_title：Bioscience reports

authors： Rennie MJ,Fell RD,Ivy JL,Holloszy JO

更新日期：1982-05-01 00:00:00

abstract：:Erythrocytes suspended in a medium of low ionic strength lyse under the effect of an exponential electrical pulse. The percentage of haemolysed cells decreases several-fold in the presence of divalent cations. The protective action of the ions studied increases in the following order: Ca++, Mg++, Zn++. It is assumed t...

journal_title：Bioscience reports

authors： Tomov TC,Tsoneva IC,Doncheva JC

更新日期：1988-10-01 00:00:00

abstract：:NOX (NADPH oxidase) plays an important role during several pathologies because it produces the superoxide anion (O2•-), which reacts with NO (nitric oxide), diminishing its vasodilator effect. Although different isoforms of NOX are expressed in ECs (endothelial cells) of blood vessels, the NOX2 isoform has been consid...

journal_title：Bioscience reports

authors： Macías-Pérez ME,Martínez-Ramos F,Padilla-Martínez II,Correa-Basurto J,Kispert L,Mendieta-Wejebe JE,Rosales-Hernández MC

更新日期：2013-08-02 00:00:00

abstract：:Activatable cell-penetrating peptides (aCPPs) allow non-viral, low cytotoxic and selective delivery of compounds into target cells for cancer therapy. In tumour cells, up-regulation of human telomerase reverse transcriptase (hTERT) frequently occurs and is being considered as a target in cancer diagnosis and treatment...

journal_title：Bioscience reports

authors： Li H,He J,Yi H,Xiang G,Chen K,Fu B,Yang Y,Chen G

更新日期：2015-03-18 00:00:00

abstract：:The sites and extents of bisulphite-mediated deamination of cytidine residues in HeLa-cell 5.8 S rRNA within the 5.8 S / 28 S rRNA complex have been determined. Comparison of these data with equivalent data for isolated ('unbound') 5.8 S rRNA suggests that the conformation of several cytidine residues, including inter...

journal_title：Bioscience reports

authors： Kelly JM,Goddard JP

更新日期：1981-05-01 00:00:00

abstract：:Hippo pathway is a highly conservative signalling pathway related to the development of organisms, which has been demonstrated to be strongly linked to the tumorigenesis and tumour progression. As the major downstream effector of Hippo pathway, yes-associated protein (YAP), is a transcriptional activator of target gen...

journal_title：Bioscience reports

authors： Wang S,Ma K,Chen L,Zhu H,Liang S,Liu M,Xu N

更新日期：2016-09-29 00:00:00

abstract：:We have investigated the intramembranal ion traffic in apoptotic 3T6 cells in culture. Apoptosis was induced by various treatments, such as serum deprivation, high density growth and hydrogen peroxide at subnecrotic doses. Cell death was assessed by nucleosomal DNA fragmentation, single cell electrophoresis, immunoflu...

journal_title：Bioscience reports

authors： Bonincontro A,Iacoangeli A,Melucci-Vigo G,Risuleo G

更新日期：1997-12-01 00:00:00

abstract：:A family of artificial proteins, named αRep, based on a natural family of helical repeat was previously designed. αRep members are efficiently expressed, folded and extremely stable proteins. A large αRep library was constructed creating proteins with a randomized interaction surface. In the present study, we show tha...

journal_title：Bioscience reports

authors： Chevrel A,Urvoas A,Li de la Sierra-Gallay I,Aumont-Nicaise M,Moutel S,Desmadril M,Perez F,Gautreau A,van Tilbeurgh H,Minard P,Valerio-Lepiniec M

更新日期：2015-06-12 00:00:00

abstract：:Emerging evidence are accumulating that long noncoding RNAs (lncRNAs) have recently been identified to participate in various cellular processes. Terminal differentiation induced ncRNA (TINCR) is a newly identified lncRNA with its functional roles not fully elucidated in human malignancy. The current study aims to ide...

journal_title：Bioscience reports

authors： Tian F,Xu J,Xue F,Guan E,Xu X

更新日期：2017-07-27 00:00:00

abstract：:Amphiphilic anionic peptides have been used to enhance the efficiency of transfection by helping plasmids to escape from endosomes to the cytosol. It has been shown that efficiency of an eicosamers containing five glutamyl residues (E5), can be considerably enhanced either by transforming it into a dimer or by adding ...

journal_title：Bioscience reports

authors： Freulon I,Monsigny M,Midoux P,Mayer R

更新日期：2000-10-01 00:00:00

abstract：:Prognostic significance of family with sequence similarity 83, member D (FAM83D) in hepatocellular carcinoma (HCC) patients has not been well-investigated using Gene Expression Omnibus (GEO) series and TCGA database, we compared FAM83D expression levels between tumor and adjacent tissues, and correlated FAM83D in tumo...

journal_title：Bioscience reports

authors： Liu X,Gao H,Zhang J,Xue D

更新日期：2019-05-07 00:00:00

abstract：:The high proliferation rate of tumor cells demands high energy and metabolites that are sustained by a high glycolytic flux known as the 'Warburg effect'. The activation and further metabolism of glucose is initiated by hexokinase, a focal point of metabolic regulation. The human hexokinase 2 (HK2) is overexpressed in...

journal_title：Bioscience reports

authors： Nawaz MH,Ferreira JC,Nedyalkova L,Zhu H,Carrasco-López C,Kirmizialtin S,Rabeh WM

更新日期：2018-02-21 00:00:00

abstract：:MicroRNA-326 (miR-326) was reported to be dysregulated and involved in the progression of multiple cancers. However, the clinical significance, biological role and underlying mechanism of miR-326 in the carcinogenesis of breast cancer are still unclear. In the present study, we showed that miR-326 was down-regulated i...

journal_title：Bioscience reports

authors： Du Y,Shen L,Zhang W,Ding R,Li Q,Li S,Zhang H

更新日期：2019-07-29 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) complicated with non-alcoholic fatty liver disease (NAFLD) is difficult to treat. The present study explored the efficacy of (liraglutide) Lira in treating T2DM complicated with NAFLD. A total of 127 patients suffering from T2DM complicated with NAFLD were enrolled in the present study,...

journal_title：Bioscience reports

authors： Tian F,Zheng Z,Zhang D,He S,Shen J

更新日期：2018-12-21 00:00:00

abstract：:The 250-kDa sialoglycoprotein of bovine erythrocyte membranes, GP-2, has been found to be an exceptionally rich source of branched sialo-oligosaccharides of poly-N-acetyllactosamine (I antigen) type with receptor activity for the human pathogen Mycoplasma pneumoniae. Desialylated GP-2 is the most potent I-active subst...

journal_title：Bioscience reports

authors： Feizi T,Gooi HC,Loomes LM,Suzuki Y,Suzuki T,Matsumoto M

更新日期：1984-09-01 00:00:00

abstract：:Kawasaki disease (KD) is a type of disease that includes the development of a fever that lasts at least 5 days and involves the clinical manifestation of multicellular vasculitis. KD has become one of the most common pediatric cardiovascular diseases. Previous studies have reported that miR-218 rs11134527 A>G is assoc...

journal_title：Bioscience reports

authors： Pi L,Fu L,Xu Y,Che D,Deng Q,Huang X,Li M,Zhang L,Huang P,Gu X

更新日期：2018-05-22 00:00:00

abstract：:The proton conductance of the mitochondrial inner membrane can be quantified by applying Ohm's law to the experimentally determined protonmotive force and the proton current flowing around the proton circuit in the absence of ATP synthesis or ion transport. This last parameter is derived from the rate of State 4 respi...

journal_title：Bioscience reports

authors： Nicholls DG

更新日期：1997-06-01 00:00:00

abstract：:The present study aimed to evaluate what dosage of gold nanoparticles (GNPs) would improve growth performance, antioxidant levels and immune defense in broiler chickens. The experiment was carried out on 90 one-day-old mixbred Cobb chicks. The birds were allocated into three groups with three replicates. Group (1) kep...

journal_title：Bioscience reports

authors： Hassanen EI,Morsy EA,Hussien AM,Ibrahim MA,Farroh KY

更新日期：2020-03-27 00:00:00

abstract：:The present study was designed to investigate the protective effect of moracin on primary culture of nucleus pulposus cells in intervertebral disc and explore the underlying mechanism. Moracin treatment significantly inhibited the LPS-induced inflammatory cytokine accumulation (IL-1β, IL-6 and TNF-α) in nucleus pulpos...

journal_title：Bioscience reports

authors： Gu R,Huang Z,Liu H,Qing Q,Zhuan Z,Yang L,Su Z,Huang W

更新日期：2019-12-20 00:00:00

abstract：:Whether serum copper levels were higher in patients with cervical cancer than that in controls was controversial. Hence, we conducted the present study to explore the relationship between serum copper levels and cervical cancer. We searched PubMed, WanFang, and China National Knowledge Internet (CNKI) for relevant stu...

journal_title：Bioscience reports

authors： Zhang M,Shi M,Zhao Y

更新日期：2018-07-06 00:00:00

abstract：:The 7-nitro-2,1,3-nitrobenzoxadiazole (NBD) derivatives are a series of compounds containing the NBD scaffold that are not glutathione (GSH) peptidomimetics, and result in a strong inhibition of glutathione S-transferases (GSTs). Growing evidences highlight their pivotal roles and outstanding anticancer activity in di...

journal_title：Bioscience reports

authors： Sha HH,Wang Z,Dong SC,Hu TM,Liu SW,Zhang JY,Wu Y,Ma R,Wu JZ,Chen D,Feng JF

更新日期：2018-02-13 00:00:00

abstract：:Non-Small Cell Lung Cancer (NSCLC) is responsible for the majority of deaths caused by cancer. Small C-terminal domain (CTD) phosphatases (SCP), CTDSP1, CTDSP2 and CTDSPL (CTDSPs) belong to SCP/CTDSP subfamily and are involved in many vital cellular processes and tumorigenesis. High similarity of their structures sugg...

journal_title：Bioscience reports

authors： Krasnov GS,Puzanov GA,Afanasyeva MA,Dashinimaev EB,Vishnyakova KS,Beniaminov AD,Adzhubei AA,Kondratieva TT,Yegorov YE,Senchenko VN

更新日期：2019-12-20 00:00:00

abstract：:Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb) which has been threatening global public health for many years. High genetic diversity is dominant feature of Mtb. Increasing cases of multidrug-resistant (MDR) tuberculosis (MDR-TB) is a serious public health problem to TB control i...

journal_title：Bioscience reports

authors： Bai R,Chi S,Li X,Dai X,Ji Z,Jian M,Bi Y,Wang F,Ding Z,Luo L,Chen T,Liu A,Bao F

更新日期：2019-05-31 00:00:00