Abstract:
:Gallbladder cancer (GBC) is a relatively rare but fatal gastrointestinal tumor. The microRNA-33b (miR-33b), a member of miR-33 family, is reported to function as a tumor suppressor in various cancers. Notably, miR-33 was predicted to target CROCC based on microarray-based analysis. Hereby, we aimed to characterize the effect of miR-33b on epithelial-mesenchymal transition (EMT) in GBC and the potential mechanism involved with the regulation of CROCC. In GBC cell lines, miR-33b expressed at low levels, and CROCC expressed at high levels, with enhanced EMT process. To further examine the specific mechanism of miR-33b and CROCC in GBC, the GBC cells were treated with the miR-33b mimic/inhibitor or siRNA-CROCC to assess the expression alteration of EMT-related genes and cell proliferation, migration, and invasion. MiR-33b was verified to target and down-regulate the expression of CROCC. The miR-33b up-regulation or CROCC silencing was observed to increase the level of E-cadherin but decrease the levels of N-cadherin and Vimentin, corresponding to impeded cell proliferation, migration, invasion, EMT, and tumor growth. The findings suggest that miR-33b up-regulation hinders GBC development through down-regulating CROCC, which was achieved by inhibition of EMT. The present study may provide an insight on a novel target for GBC treatment.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Xu G,Wei X,Tu Q,Zhou Cdoi
10.1042/BSR20190108subject
Has Abstractpub_date
2020-01-31 00:00:00issue
1eissn
0144-8463issn
1573-4935pii
221400journal_volume
40pub_type
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01114811
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20170302
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190482
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journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1007/BF01362501
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journal_title:Bioscience reports
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journal_title:Bioscience reports
pub_type: 杂志文章,评审
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journal_title:Bioscience reports
pub_type: 杂志文章,meta分析
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journal_title:Bioscience reports
pub_type: 杂志文章,评审
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01114835
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journal_title:Bioscience reports
pub_type: 杂志文章
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doi:10.1042/BSR20190337
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journal_title:Bioscience reports
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doi:10.1042/BSR20181640
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journal_title:Bioscience reports
pub_type: 传,历史文章
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20170707
更新日期:2017-07-07 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20193877
更新日期:2021-01-27 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20170047
更新日期:2017-03-27 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01117011
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journal_title:Bioscience reports
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doi:10.1007/BF01115230
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journal_title:Bioscience reports
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journal_title:Bioscience reports
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journal_title:Bioscience reports
pub_type: 杂志文章
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journal_title:Bioscience reports
pub_type: 杂志文章
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journal_title:Bioscience reports
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journal_title:Bioscience reports
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journal_title:Bioscience reports
pub_type: 杂志文章
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journal_title:Bioscience reports
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01314215
更新日期:1982-08-01 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1023/a:1027399921351
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