Abstract:
:Kinesin family member 14 (KIF14) is a member of kinesin family proteins which have been found to be dysregulated in various cancer types. However, the expression of KIF14 and its potential prognostic significance have not been investigated in cervical cancer. Real-time PCR was performed to assess the expression levels of KIF14 in 47 pairs of cervical cancer tissues and their matched normal tissues from patients who had not been exposed to chemotherapy as well as tissue samples from 57 cervical cancer patients who are sensitive to paclitaxel treatment and 53 patients who are resistant. The association between KIF14 expression levels in tissue and clinicopathological features or chemosensitivity was examined. Kaplan-Meier analysis and Cox proportional hazards model were applied to assess the correlation between KIF14 expression levels and overall survival (OS) of cervical cancer patients. KIF14 expression levels were significantly increased in cervical cancer tissues compared with matched non-cancerous tissues and it was higher in tissues of patients who are chemoresistant compared with those who are chemosensitive. KIF14 expression was positively associated with high tumour stage (P=0.0044), lymph node metastasis (P=0.0034) and chemoresistance (P<0.0001). Kaplan-Meier analysis showed that high KIF14 expression levels predicted poor survival in patients with (P=0.0024) or without (P=0.0028) paclitaxel treatment. Multivariate analysis revealed that KIF14 was an independent prognostic factor for OS. Our study suggests that KIF14 may serve as a predictor of poor survival and a novel prognostic biomarker of chemoresistance to paclitaxel treatment in cervical cancer.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Wang W,Shi Y,Li J,Cui W,Yang Bdoi
10.1042/BSR20150314subject
Has Abstractpub_date
2016-04-05 00:00:00issue
2eissn
0144-8463issn
1573-4935pii
BSR20150314journal_volume
36pub_type
杂志文章abstract::We have investigated the intramembranal ion traffic in apoptotic 3T6 cells in culture. Apoptosis was induced by various treatments, such as serum deprivation, high density growth and hydrogen peroxide at subnecrotic doses. Cell death was assessed by nucleosomal DNA fragmentation, single cell electrophoresis, immunoflu...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1023/a:1027364308147
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journal_title:Bioscience reports
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journal_title:Bioscience reports
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journal_title:Bioscience reports
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journal_title:Bioscience reports
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journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1007/BF01788360
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01119197
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20191496
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190337
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journal_title:Bioscience reports
pub_type: 杂志文章
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116377
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01145177
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journal_title:Bioscience reports
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Bioscience reports
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pub_type: 杂志文章
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20171082
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journal_title:Bioscience reports
pub_type: 杂志文章,meta分析
doi:10.1042/BSR20181857
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20200422
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01114948
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abstract::The unicellular Tetrahymena enzymatically split the synthetic phosphodiester, 4-methylumbelliferyl phosphocholine substrate. The enzyme activity was completely blocked in vitro and drastically inhibited in vivo by G-protein activating fluorides (NaF; AIF4- and BeF3-). The phospholipase A2 inhibitor, quinacrine, and th...
journal_title:Bioscience reports
pub_type: 杂志文章
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01117517
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journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1042/BSR20170204
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01115230
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