Abstract:
:Four days of fasting in the rat reduced brown-adipose-tissue (BAT) mass, mitochondrial protein, and tissue protein content. Specific binding of guanosine diposphate (GDP) to BAT mitochondria was depressed by 55% in 4d-fasted rats. Rats fasted for 3 d, and then refed a single carbohydrate meal (40 kJ), showed a significant increase in specific GDP-binding (27% above fasted) 24 h later, and a large increase in total binding. Specific activities of cytochrome oxidase and alpha-glycerophosphate dehydrogenase in BAT mitochondria were not significantly affected by fasting or refeeding. These results suggest that BAT may be partly responsible for the fall in metabolic rate associated with fasting and the delayed increase after carbohydrate refeeding. These effects may be due to changes in the mitochondrial proton-conductance pathway in brown fat.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Rothwell NJ,Saville ME,Stock MJdoi
10.1007/BF01140499subject
Has Abstractpub_date
1984-04-01 00:00:00pages
351-7issue
4eissn
0144-8463issn
1573-4935journal_volume
4pub_type
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