Abstract:
:The sodium contents of beta-cell-rich pancreatic islets from ob/ob-mice were measured with an integrating flame photometer. After washing to an apparent steady state with different types of ice-cold media, islets incubated in the absence of glucose contained 79-108 mmol sodium kg-1 dry weight. Exposure to glucose resulted in 25% reduction of the islet content of sodium. This effect became manifest in the presence of 5 mM glucose, there being no additional reduction with a further increase of glucose to 20 mM. Depression of Na+ activity may partially explain why glucose, under certain conditions, can lower cytoplasmic Ca2+ and even inhibit insulin release.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Wesslén N,Bergsten P,Hellman Bdoi
10.1007/BF01114973subject
Has Abstractpub_date
1986-11-01 00:00:00pages
967-72issue
11eissn
0144-8463issn
1573-4935journal_volume
6pub_type
杂志文章abstract::Choroideremia is a complex form of blindness-causing retinal degeneration. The aim of the present study was to investigate the pathogenic variant and molecular etiology associated with choroideremia in a Chinese family. All available family members underwent detailed ophthalmological examinations. Whole exome sequenci...
journal_title:Bioscience reports
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journal_title:Bioscience reports
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journal_title:Bioscience reports
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journal_title:Bioscience reports
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journal_title:Bioscience reports
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journal_title:Bioscience reports
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