Abstract:
:N-(2-Hydroxypropyl)methacrylamide copolymers bearing oligopeptide side-chains terminating in p-nitroaniline (NAp) were incubated with rat liver lysosomal enzymes in the presence of the thiol glutathione, and the rate of p-nitroaniline release was measured. Twelve of the 16 side-chains investigated were hydrolysed to release p-nitroaniline and in all but one case degradation was partially or totally inhibited by leupeptin. The effect of substrate concentration on the degradation of the most readily cleaved side-chain, -Ala-Gly-Val-Phe-NAp, was measured.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Duncan R,Cable HC,Lloyd JB,Rejmanová P,Kopecek Jdoi
10.1007/BF01122173subject
Has Abstractpub_date
1982-12-01 00:00:00pages
1041-6issue
12eissn
0144-8463issn
1573-4935journal_volume
2pub_type
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