High-affinity folate binding in human liver membranes.

abstract：:The present study aimed to evaluate what dosage of gold nanoparticles (GNPs) would improve growth performance, antioxidant levels and immune defense in broiler chickens. The experiment was carried out on 90 one-day-old mixbred Cobb chicks. The birds were allocated into three groups with three replicates. Group (1) kep...

journal_title：Bioscience reports

authors： Hassanen EI,Morsy EA,Hussien AM,Ibrahim MA,Farroh KY

更新日期：2020-03-27 00:00:00

abstract：:Bleaching of the purple membrane strongly reduces the number of divalent cation binding sites as well as their affinities. Conversely, deionization of the bleached membrane drastically inhibits the chromophore regeneration. Proteolysis experiments using bromelain show that the bleached membrane has an additional cleav...

journal_title：Bioscience reports

authors： Duñach M,Seigneuret M,Rigaud JL,Padrós E

更新日期：1986-11-01 00:00:00

abstract：:The cellular onc-genes c-src and c-yes are expressed very differently during chicken embryonic development. The c-src mRNA and its translational product are detectable at high levels in brain extracts of chicken embryos and adult chickens, whereas muscle extracts show an age-dependent decrease in the amounts of c-src-...

journal_title：Bioscience reports

authors： Gessler M,Barnekow A

更新日期：1984-09-01 00:00:00

abstract：:Interleukin-21 (IL-21) is a cytokine that plays a crucial role in pathogenesis and activity of the rheumatoid arthritis (RA). Meanwhile, genetic polymorphisms in the IL-21 gene may alter its expression. Previous studies have reported conflicting results assessing the association between the IL-21 rs6822844 G/T polymor...

journal_title：Bioscience reports

authors： Yu M,Hou J,Zheng M,Cao Y,Alike Y,Mi Y,Zhu J

更新日期：2020-01-31 00:00:00

abstract：:Signal transducer and activator of transcription (STAT), a family of latent cytoplasmic transcription factors, are composed of seven identified members (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). STATs are associated with several biological processes such as cell proliferation, invasion, and metastasis in var...

journal_title：Bioscience reports

authors： Li S,Sheng B,Zhao M,Shen Q,Zhu H,Zhu X

更新日期：2017-07-16 00:00:00

abstract：:Inactivation of p53 is one of the most relevant events in human cancer, since it allows transformed cells to escape their own proliferation control and leave them irresponsive to drugs that aim to damage their DNA. When p53 falls, other members of its family may become targets to attack tumoural cells. p73 has shown c...

journal_title：Bioscience reports

authors： Sánchez-Carrera D,García-Puga M,Yáñez L,Romón Í,Pipaón C

更新日期：2015-04-28 00:00:00

abstract：:The present study describes the enzymatic properties and molecular identification of 5'-nucleotidase in soluble and microsomal fractions from rat cardiac ventricles. Using AMP as a substrate, the results showed that the cation and the concentration required for maximal activity in the two fractions was magnesium at a ...

journal_title：Bioscience reports

authors： Pochmann D,Innocente AM,Cotomacci G,Barreto-Chaves ML,Sarkis JJ

更新日期：2008-10-01 00:00:00

abstract：:Cell membranes have important functions in many steps of the blood coagulation cascade, including the activation of factor X (FX) by the factor VIIa (FVIIa)-tissue factor (TF) complex (extrinsic Xase). FVIIa shares structural similarity with factor IXa (FIXa) and FXa. FIXa and FXa are regulated by binding to phosphati...

journal_title：Bioscience reports

authors： Sengupta T,Koklic T,Lentz BR,Majumder R

更新日期：2021-01-22 00:00:00

abstract：:As a zinc transporter, SLC39A7 (zip7) is vital in intestinal epithelial self-renewal, and recent studies suggested that SLC39A7 was related to cancer progression. Whereas, little is known about the role of SLC39A7 in gastric cancer (GC). In the present study, qRT-PCR analysis demonstrated that SLC39A7 mRNA level was i...

journal_title：Bioscience reports

authors： Zhang Y,Bai J,Si W,Yuan S,Li Y,Chen X

更新日期：2020-02-28 00:00:00

abstract：:Nonsmall cell lung cancer (NSCLC) is one of the most frequent malignancies worldwide. Long noncoding RNAs (LncRNAs) play critical roles in cancer initiation and progression. Previous studies have demonstrated that overexpression of cytoskeleton regulator RNA (CYTOR) predicates poor prognosis and promotes tumor progres...

journal_title：Bioscience reports

authors： Zhang J,Li W

更新日期：2018-12-18 00:00:00

abstract：:Our study aimed at exploring the effects of miR-211 on the proliferation and apoptosis of lens epithelial cells in diabetic cataract mice by targetting NAD+-dependent histone deacetylase sirtulin 1 (SIRT1). Healthy male mice were assigned into normal and diabetic cataract groups. Blood glucose, lens turbidity, and apo...

journal_title：Bioscience reports

authors： Zeng K,Feng QG,Lin BT,Ma DH,Liu CM

更新日期：2017-07-27 00:00:00

abstract：:Hepatocellular carcinoma (HCC) has a high recurrence rate and poor clinical outcome after currently used therapies, including radiofrequency ablation. To explore the possible mechanisms for the relapse of HCC, in the present study we focussed on long non-coding RNA (LncRNA), which has been reported to be involved in t...

journal_title：Bioscience reports

authors： Zhu X,Yu H,Li B,Quan J,Zeng Z,Li G,Liu J

更新日期：2019-11-29 00:00:00

abstract：:microRNAs (miRNAs) have been found to affect various cancers, and expression of numerous miRNAs is revealed in glioma. However, the role of microRNA-30b-3p (miR-30b-3p) in glioma remains elusive. Therefore, the present study aims to explore the specific mechanism by which miR-30b-3p influence the development of glioma...

journal_title：Bioscience reports

authors： Jian Y,Xu CH,Li YP,Tang B,Xie SH,Zeng EM

更新日期：2019-08-13 00:00:00

abstract：:The hematopoietic cell kinase (HCK), a member of the Src family protein-tyrosine kinases (SFKs), is primarily expressed in cells of the myeloid and B lymphocyte lineages. Nevertheless, the roles of HCK in glioblastoma (GBM) remain to be examined. Thus, we aimed to investigate the effects of HCK on GBM development both...

journal_title：Bioscience reports

authors： Wang Z,Ying C,Zhang A,Xu H,Jiang Y,Lou M

更新日期：2020-06-26 00:00:00

abstract：:The emergence of multidrug-resistant (MDR) microbes caused by overuse of antibiotics leads to urgent demands for novel antibiotics exploration. Our recent data showed that Ly2.1-3 (a novel lymphocyte antigen 6 (Ly6) gene cluster) were proteins with cationic nature and rich in cysteine content, that are characteristic ...

journal_title：Bioscience reports

authors： Liu X,Cao X,Wang S,Ji G,Zhang S,Li H

更新日期：2017-01-17 00:00:00

abstract：:The preadipocyte differentiation biological process involves a cascade of transcriptional events that culminates in the expression of peroxisome proliferator-activated receptor (PPAR) γ. The differentiation cocktail [insulin (INS), dexamethasone (DEX) and isobutylmethylxanthine (IBMX)] can induce preadipocyte differen...

journal_title：Bioscience reports

authors： Cheng B,Wu M,Xu S,Zhang X,Wang Y,Wang N,Leng L,Li H

更新日期：2016-11-03 00:00:00

abstract：:The marbled rockfish Sebastiscus marmoratus is an ecologically and economically important marine fish species distributed along the northwestern Pacific coast from Japan to the Philippines. Here, next-generation sequencing was used to generate a whole genome survey dataset to provide fundamental information of its gen...

journal_title：Bioscience reports

authors： Xu SY,Song N,Xiao SJ,Gao TX

更新日期：2020-02-28 00:00:00

abstract：:The present study was conducted with the aim being to investigate the effect γ-aminobutyric acid type B (GABAB) receptor activation have on spatial cognitive function and hippocampal neurones found in the rat models of type 2 diabetes mellitus (T2DM). T2DM rat models were then established, randomized, and subsequently...

journal_title：Bioscience reports

authors： Cai XJ,Wang L,Hu CM

更新日期：2018-01-19 00:00:00

abstract：BACKGROUND:Emerging evidences have indicated that long non-coding RNAs (LncRNAs) play vital roles in cancer development and progression. Previous studies have suggested that overexpression of SPRY4 intronic transcript 1 (SPRY4-IT1) predicates poor prognosis and promotes tumor progress in cervical cancer (CC). However, ...

journal_title：Bioscience reports

authors： Fan MJ,Zou YH,He PJ,Zhang S,Sun XM,Li CZ

更新日期：2019-06-04 00:00:00

abstract：:Whether they are small enough to wriggle through the current-carrying part of an ionic channel or big enough to be kept outside and thus able to exert an osmotic stress on the channel space, polymers interact with channels in several instructive ways. The osmotic stress of excluded polymers allows one to measure the n...

journal_title：Bioscience reports

authors： Parsegian VA,Bezrukov SM,Vodyanoy I

更新日期：1995-12-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a life-threatening chronic cardiopulmonary disorder. However, studies providing PAH-related gene expression profiles are scarce. To identify hub genes involved in PAH, we investigate two microarray data sets from gene expression omnibus (GEO). A total of 150 differentially expr...

journal_title：Bioscience reports

authors： Ma Y,Chen SS,Feng YY,Wang HL

更新日期：2020-09-30 00:00:00

abstract：:Particulate membrane fractions from calf liver catalyze the release of glucose from GlcNAc2-Man9-Glc1-3-oligosaccharides. Maximal oligosaccharide-glucosidase activity was obtained at pH 6.2 and a detergent concentration of 0.5% Triton X-100. This activity could be distinguished from non-specific alpha-glucosidase acti...

journal_title：Bioscience reports

authors： Hettkamp H,Bause E,Legler G

更新日期：1982-11-01 00:00:00

abstract：:The tetracycline repressor (TetR)-regulated system is a widely used tool to study gene functions through control of its expression. Various effectors such as tetracycline (Tc) and doxycycline (Dox) quickly induce or shut down gene expression, but reversing gene expression has not been eligible due to long half-lives o...

journal_title：Bioscience reports

authors： Song C,Kim N,Park M,Lee J,Oh KB,Sim T

更新日期：2019-01-08 00:00:00

abstract：:Chemical transformations, like osmotic translocations, are transport processes when looked at in detail. In chemiosmotic systems, the pathways of specific ligand conduction are spatially orientated through osmoenzymes and porters in which the actions of chemical group, electron and solute transfer occur as vectorial (...

journal_title：Bioscience reports

authors： Mitchell PD

更新日期：2004-08-01 00:00:00

abstract：:Virus replication inhibitory peptide (carbobenzoxy-D-Phe-L-PheGly) was shown to be a potent specific inhibitor of the replication of paramyxovirus and myxovirus (Richardson, Scheid and Choppin (1980), Virology 105, 205-222). This peptide inhibits the membrane fusing activity of a viral glycoprotein. Many agents which ...

journal_title：Bioscience reports

authors： Epand RM

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:Annulus fibrosus (AF) is important to confine disc nucleus pulposus (NP) tissue during mechanical load experience. However, the knowledge on AF cell biology under mechanical load is much limited compared with disc NP. OBJECTIVE:The present study aimed to investigate responses of apoptosis and matrix metabol...

journal_title：Bioscience reports

authors： Jiang Y,Fu L,Song Y

更新日期：2019-02-22 00:00:00

abstract：:Imipramine and clorgyline, at concentrations of 0.002 M, inhibit the respiration of brain tissue by 82 and 71 per cent respectively, while chloropromazine and tranylcypromine, at concentrations of 0.01 M, inhibit it about 25 per cent. Deprenyl and amphetamine at a concentration of 0.002 M inhibit brain tissue respirat...

journal_title：Bioscience reports

authors： Nag M,Nandi N

更新日期：1991-02-01 00:00:00

abstract：:Mouse Mex3c encodes RNA-binding proteins of variant length through alternative splicing. Its mutation results in multiple defects including growth retardation, perturbed energy balance, and defective antiviral innate immunity. Here we report that Mex3c mutation affects mammary gland development and lactation in female...

journal_title：Bioscience reports

authors： Du Y,Sun D,Li Y

更新日期：2020-12-23 00:00:00

abstract：:Background: Nasopharyngeal carcinoma (NPC) is a disease highly sensitive to radiotherapy with the unclear etiology. However, the specific effects of microRNA-613 (miR-613) on NPC still remain elusive. Therefore, the present study probes into the underlying mechanism of miR-613 in NPC via AKT signaling pathway by regul...

journal_title：Bioscience reports

authors： Gao R,Feng Q,Tan G

更新日期：2019-07-10 00:00:00

abstract：:Prefoldin subunits (PFDN), primarily known for co-chaperone function associated with cytoskeletal rearrangement, have been found involved in epithelial-mesenchymal transition (EMT) and cancer progression. However, studies focusing on the roles of PFDN in gastric cancer (GC) remain limited. The present study aims to ev...

journal_title：Bioscience reports

authors： Yesseyeva G,Aikemu B,Hong H,Yu C,Dong F,Sun J,Zang L,Zheng M,Ma J

更新日期：2020-02-28 00:00:00