Clusterin role in hepatocellular carcinoma patients treated with oxaliplatin.

abstract：:Background: There is a clinical need for the use of engineered adipose tissue in place of surgical reconstruction. We previously found that the external volume expansion (EVE) device increased special cell clusters in well-vascularized connective stroma during adipose regeneration. However, the origin of these cell cl...

journal_title：Bioscience reports

authors： Chen X,He Y,Xu A,Deng Z,Feng J,Lu F,Yuan Y

更新日期：2019-02-26 00:00:00

abstract：:Brain metastases are the most common intracranial tumors in adults. They usually originate from: lung, breast, renal cell and gastrointestinal cancers, as well as melanoma. Prognosis for brain metastases is still poor and classical treatment combining surgery and radiation therapy should be strongly supported with mol...

journal_title：Bioscience reports

authors： Barciszewska AM

更新日期：2018-10-22 00:00:00

abstract：:Circulating tumor cells can provide important diagnostic and prognostic information of the patients with non-small cell lung cancer (NSCLC). Aldehyde dehydrogenase 1 (ALDH1), a cancer stem cell marker, has been used in various tumors, including NSCLC. In the present study, we isolated the circulating ALDH1+ tumor cell...

journal_title：Bioscience reports

authors： Tian S,Xing YN,Xia P

更新日期：2018-10-31 00:00:00

abstract：:Prostate cancer (PCa), the second most mortal cancer from developed countries, presents a high level of chemoresistance. There is emerging evidence underscores the critical role of autophagy in the onset, progression, and chemoresistance of PCa. In the present study, we investigated the possible role of a novel autoph...

journal_title：Bioscience reports

authors： Liu J,Chen Z,Guo J,Wang L,Liu X

更新日期：2019-08-23 00:00:00

abstract：:Thrombospondin-2 (THBS2) is a secreted protein overexpressed in numerous cancers and may function as a diagnostic tumor marker. The objective of the present study was to investigate the diagnostic performance of serum THBS2 in early stage non-small-cell lung cancer (NSCLC). Serum THBS2 and Cyfra21-1 level were evaluat...

journal_title：Bioscience reports

authors： Jiang YM,Yu DL,Hou GX,Jiang JL,Zhou Q,Xu XF

更新日期：2019-07-25 00:00:00

abstract：:The Gram-positive bacterium Staphylococcus pseudintermedius is a leading cause of canine bacterial pyoderma, resulting in worldwide morbidity in dogs. S. pseudintermedius also causes life-threatening human infections. Furthermore, methicillin-resistant S. pseudintermedius is emerging, resembling the human health threa...

journal_title：Bioscience reports

authors： Abate F,Malito E,Cozzi R,Lo Surdo P,Maione D,Bottomley MJ

更新日期：2014-11-24 00:00:00

abstract：:Mitochondria are known to participate in the initiation of programmed cell death (PCD) in animals and in plants. The role of chloroplasts in PCD is still unknown. We describe a new system to study PCD in plants; namely, leaf epidermal peels. The peel represents a monolayer consisting of cells of two types: phototrophi...

journal_title：Bioscience reports

authors： Samuilov VD,Lagunova EM,Kiselevsky DB,Dzyubinskaya EV,Makarova YV,Gusev MV

更新日期：2003-04-01 00:00:00

abstract：: Background/aims: Studies have demonstrated that osteopontin (OPN) was associated with the severity and development of knee osteoarthritis (OA). Methods: The purpose of this case-control study was to investigate the association ...

journal_title：Bioscience reports

authors： Shang H,Hao Y,Hu W,Hu X,Jin Q

更新日期：2019-02-27 00:00:00

abstract：OBJECTIVE:The current study aimed to investigate the functional roles and clinical significance of microRNA-148a (miR-148a) in the progression of oral squamous cell carcinoma (OSCC). METHODS:Relative expression of miR-148a in OSCC cells and tissues were detected using quantitative real-time polymerase chain reaction (...

journal_title：Bioscience reports

authors： Jia T,Ren Y,Wang F,Zhao R,Qiao B,Xing L,Ou L,Guo B

更新日期：2020-04-30 00:00:00

abstract：:Superoxide dismutase (SOD), a metal containing enzyme is present in parasite Leishmania donovani as well as in host macrophages both resident and activated in a detectable amount, although the level is much higher in the latter case. It is observed that at any particular protein concentration, the SOD activity is high...

journal_title：Bioscience reports

authors： Mukherjee S,Bandyapadhyay R,Basu MK

更新日期：1988-04-01 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) complicated with non-alcoholic fatty liver disease (NAFLD) is difficult to treat. The present study explored the efficacy of (liraglutide) Lira in treating T2DM complicated with NAFLD. A total of 127 patients suffering from T2DM complicated with NAFLD were enrolled in the present study,...

journal_title：Bioscience reports

authors： Tian F,Zheng Z,Zhang D,He S,Shen J

更新日期：2018-12-21 00:00:00

abstract：:Isoliquiritigenin (ISL), a natural product isolated from licorice root, exhibits anti-gastric cancer effects. However, applications of ISL are still limited in clinical practice due to its poor bioavailability. To discovery of more effective anti-gastric cancer agents based on ISL, aldol condensation reaction was appl...

journal_title：Bioscience reports

authors： Huang F,Wang J,Xu Y,Zhang Y,Xu N,Yin L

更新日期：2020-06-26 00:00:00

abstract：:Bleaching of the purple membrane strongly reduces the number of divalent cation binding sites as well as their affinities. Conversely, deionization of the bleached membrane drastically inhibits the chromophore regeneration. Proteolysis experiments using bromelain show that the bleached membrane has an additional cleav...

journal_title：Bioscience reports

authors： Duñach M,Seigneuret M,Rigaud JL,Padrós E

更新日期：1986-11-01 00:00:00

abstract：:Heterotopic ossification (HO) is the aberrant formation of mature, lamellar bone in nonosseous tissue. Fibrodysplasia ossificans progressiva (FOP) is a rare and devastating genetic disorder that causes progressive HO in the ligaments, tendons, and muscles throughout the body. FOP is attributed to an autosomal mutation...

journal_title：Bioscience reports

authors： Lin H,Shi F,Gao J,Hua P

更新日期：2019-08-02 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is the most common malignancy in the oral cavity, which accounts for >90% of all diagnosed oral cancers. 2-phenylethynesulfonamide (PES) was known as a selective heat shock protein 70 (Hsp70) function inhibitor, which induced cytotoxic effects on various tumor cell types, but showed...

journal_title：Bioscience reports

authors： Jiang L,Xiao J

更新日期：2020-03-27 00:00:00

abstract：:Chagas disease remains a serious health problem for countries where the most common mode of transmission is infection contracted from the feces of a Triatominae insect vector. In México, 32 species of Triatoma have been identified; amongst them, Triatoma (Meccus) pallidipennis is an endemic species reported to have hi...

journal_title：Bioscience reports

authors： Díaz-Garrido P,Sepúlveda-Robles O,Martínez-Martínez I,Espinoza B

更新日期：2018-09-28 00:00:00

abstract：:NOX (NADPH oxidase) plays an important role during several pathologies because it produces the superoxide anion (O2•-), which reacts with NO (nitric oxide), diminishing its vasodilator effect. Although different isoforms of NOX are expressed in ECs (endothelial cells) of blood vessels, the NOX2 isoform has been consid...

journal_title：Bioscience reports

authors： Macías-Pérez ME,Martínez-Ramos F,Padilla-Martínez II,Correa-Basurto J,Kispert L,Mendieta-Wejebe JE,Rosales-Hernández MC

更新日期：2013-08-02 00:00:00

abstract：:Artocarpus incisa (breadfruit) seeds contain three different lectins (Frutalin, Frutapin (FTP) and Frutackin) with distinct carbohydrate specificities. The most abundant lectin is Frutalin, an α-D-galactose-specific carbohydrate-binding glycoprotein with antitumour properties and potential for tumour biomarker discove...

journal_title：Bioscience reports

authors： de Sousa FD,da Silva BB,Furtado GP,Carneiro IS,Lobo MDP,Guan Y,Guo J,Coker AR,Lourenzoni MR,Guedes MIF,Owen JS,Abraham DJ,Monteiro-Moreira ACO,Moreira RA

更新日期：2017-07-21 00:00:00

abstract：BACKGROUND/AIMS:MicroRNAs (miRNAs) are involved in the pathogenesis of osteoarthritis (OA). The present study aimed to investigate the potential function of miR-122 in the development of OA and its potential molecular mechanisms. METHODS:The expression of miR-122, silent information regulator 1 (SIRT1), collagen II, a...

journal_title：Bioscience reports

authors： Bai Y,Chen K,Zhan J,Wu M

更新日期：2020-06-26 00:00:00

abstract：:Long non-coding RNA (lncRNA) H19 has been implicated in tumor angiogenesis. However, whether H19 regulates the progression of corneal neovascularization (CNV) is unclear. The present study aimed to determine the function of H19 in CNV and its possible molecular mechanism. Here, we found that the H19 levels were remark...

journal_title：Bioscience reports

authors： Sun B,Ding Y,Jin X,Xu S,Zhang H

更新日期：2019-05-02 00:00:00

abstract：:Gallbladder cancer (GBC) is a relatively rare but fatal gastrointestinal tumor. The microRNA-33b (miR-33b), a member of miR-33 family, is reported to function as a tumor suppressor in various cancers. Notably, miR-33 was predicted to target CROCC based on microarray-based analysis. Hereby, we aimed to characterize the...

journal_title：Bioscience reports

authors： Xu G,Wei X,Tu Q,Zhou C

更新日期：2020-01-31 00:00:00

abstract：:Previous studies demonstrated that the adaptive response to stressors and inflammatory signals involves the activation of the autonomous [corrected] nervous system. Catecholamines have been shown to modulate the activity of various immune effector cells directly via membrane adrenergic receptors. Here, we investigated...

journal_title：Bioscience reports

authors： Lünemann JD,Buttgereit F,Tripmacher R,Baerwald CG,Burmester GR,Krause A

更新日期：2001-10-01 00:00:00

abstract：:Baicalin is the main bioactive component extracted from the traditional Chinese medicine Baical Skullcap Root, and its anti-tumor activity has been studied in previous studies. PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK), a serine/threonine protein kinase, is highly expressed in many cancer cell...

journal_title：Bioscience reports

authors： Diao X,Yang D,Chen Y,Liu W

更新日期：2019-04-09 00:00:00

abstract：:Facioscapulohumeral muscular dystrophy (FSHD) region gene 1 (FRG1) is a candidate gene for FSHD. FRG1 regulates various muscle-related functions, but studies have proposed its role in development and angiogenesis also, where it is involved with tumor-associated molecules. Therefore, we decided to look into its role in...

journal_title：Bioscience reports

authors： Tiwari A,Pattnaik N,Mohanty Jaiswal A,Dixit M

更新日期：2017-10-27 00:00:00

abstract：:This study proposed a deep learning (DL) algorithm to predict survival in patients with colon adenocarcinoma (COAD) based on multi-omics integration. The survival-sensitive model was constructed using an autoencoder for DL implementation based on The Cancer Genome Atlas (TCGA) data of patients with COAD. The autoencod...

journal_title：Bioscience reports

authors： Lv J,Wang J,Shang X,Liu F,Guo S

更新日期：2020-12-01 00:00:00

abstract：:This short article provides a comment on the recent article by Tauriainen et al. [Bioscience Reports (2018) 38, BSR20171274 https://doi.org/10.1042/BSR20171274]. ...

journal_title：Bioscience reports

authors： Plat J,Baumgartner S,Houben T,Vreugdenhil ACE,Mensink RP,Lütjohann D,Shiri-Sverdlov R

更新日期：2018-10-31 00:00:00

abstract：:Since the Protein Data Bank (PDB) was founded in 1971, there are now over 120,000 depositions, the majority of which are from X-ray crystallography and 90% of those made use of synchrotron beamlines. At the Cambridge Structure Database (CSD), founded in 1965, there are more than 800,000 'small molecule' crystal struct...

journal_title：Bioscience reports

authors： Helliwell JR

更新日期：2017-07-04 00:00:00

abstract：:Even though red blood cell (RBC) vesiculation is a well-documented phenomenon, notably in the context of RBC aging and blood transfusion, the exact signalling pathways and kinases involved in this process remain largely unknown. We have established a screening method for RBC vesicle shedding using the Ca(2+) ionophore...

journal_title：Bioscience reports

authors： Kostova EB,Beuger BM,Klei TR,Halonen P,Lieftink C,Beijersbergen R,van den Berg TK,van Bruggen R

更新日期：2015-04-16 00:00:00

abstract：:Blood pressure (BP) is a known prognostic marker for mortality in patients on maintenance hemodialysis (MHD). However, definition of the BP and its optimal values vary essentially among different MHD populations. Our purpose was to clarify these important clinical parameters in a Chinese MHD cohort. Accordingly, we re...

journal_title：Bioscience reports

authors： Wang T,Li Y,Wu H,Chen H,Zhang Y,Zhou H,Li H

更新日期：2020-08-28 00:00:00

abstract：:Keratin 18 (KRT18) has been suggested to be overexpressed in most types of human tumor, but the expression pattern of KRT18 in colorectal cancer (CRC) remained unknown. In our research, KRT18 protein expression was markedly increased in CRC cancer tissues and cell lines compared with adjacent normal colorectal tissues...

journal_title：Bioscience reports

authors： Zhang J,Hu S,Li Y

更新日期：2019-08-13 00:00:00