Clusterin role in hepatocellular carcinoma patients treated with oxaliplatin.


AIM:To explore the prognostic value of clusterin (CLU) in hepatocellular carcinoma (HCC) patients treated with oxaliplatin (OXA). METHODS:Relative expression of plasma CLU mRNA was examined via fluorescence quantitative real-time PCR (qRT-PCR), and CLU protein level in tissue samples was detected through immunohistochemistry. Chi-square test was used to analyze the relationship between CLU mRNA expression and clinical features of HCC patients treated with OXA. Kaplan-Meier method was performed to assess overall survival for the patients, and prognostic value of CLU in HCC patients was estimated via Cox regression analysis. RESULTS:CLU expression in plasma and tissue specimens was significantly higher among HCC patients than in non-malignant controls (P < 0.001 for both). Moreover, elevated CLU mRNA was closely related to tumor stage, lymph node metastasis and response to OXA (P < 0.05). HCC patients with high CLU expression showed poor response to OXA. In addition, low CLU levels predicted long overall survival time among the study subjects (20.8 vs. 36.6 months, P < 0.001). CLU was an independent prognostic indicator for HCC patients treated with OXA (HR = 2.587, 95%CI = 1.749-3.828, P < 0.001). CONCLUSION:CLU may be a novel prognostic marker for HCC patients treated with OXA.


Biosci Rep


Bioscience reports


Wang X,Liu Y,Qin Q,Zheng T




Has Abstract


2020-02-28 00:00:00












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    authors: Li X,Lin F,Wu Y,Liu N,Wang J,Chen R,Lu Z

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    authors: Rennie MJ,Fell RD,Ivy JL,Holloszy JO

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    authors: Ondarroa M,Sharma SK,Quinn PJ

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    authors: Jiang M,Liu J,Luo T,Chen Q,Lu M,Meng D

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    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Corder R,Sykes JE,Lowry PJ

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    authors: Takahashi Y,Hori Y,Yamamoto T,Urashima T,Ohara Y,Tanaka H

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    authors: Frost MG,Mazloumi Aboukheili AM,Toth R,Walden H

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    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Jacobson L,Cohen JS

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    pub_type: 杂志文章


    authors: Hoekstra D,Klappe K

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    pub_type: 杂志文章


    authors: Wesslén N,Bergsten P,Hellman B

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    pub_type: 传,历史文章


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    authors: Sorsa T,Suomalainen K,Turto H,Lindy S

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    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Martinelli SD,Roberts TJ

    更新日期:1983-01-01 00:00:00