Abstract:
:Chromosome 14 ORF 166 (C14orf166), a protein involved in the regulation of RNA transcription and translation, has been reported to possess the potency to promote tumorigenesis; however, the role of C14orf166 in non-small-cell lung cancer (NSCLC) remains unknown. The purpose of the present study was to assess C14orf166 expression and its clinical significance in NSCLC. Immunohistochemical staining, quantitative real-time PCR (qRT-PCR), and Western blotting were used to detect the C14orf166 protein and mRNA expression levels in NSCLC tissues compared with adjacent normal tissues, as well as in NSCLC cells lines compared with normal human bronchial epithelial cells (HBE). Then, the correlations between the C14orf166 expression levels and the clinicopathological features of NSCLC were analyzed. Additionally, the Cox proportional hazard model was used to evaluate the prognostic significance of C14orf166. We found that C14orf166 expression increased in carcinoma tissues compared with their adjacent normal tissues at the protein (P<0.001) and mRNA levels (P<0.001). High expression of C14orf166 was significantly associated with the T stage (P=0.006), lymph node metastasis (P=0.001), advanced TNM stage (P<0.001), and chemotherapy (P<0.001). Moreover, according to the survival analysis, patients with overexpressed C14orf166 were inclined to experience a shorter overall survival and disease-free survival time (P<0.001). Multivariate COX analysis implied that C14orf166 was an independent prognostic biomarker. Taken together, our findings indicate that the overexpression of C14orf166 may contribute to the disease progression of NSCLC, represent a novel prognostic predictor and help high-risk patients make better decisions for subsequent therapy.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Zhou YW,Li R,Duan CJ,Gao Y,Cheng YD,Zhang CFdoi
10.1042/BSR20180479subject
Has Abstractpub_date
2018-09-13 00:00:00issue
5eissn
0144-8463issn
1573-4935pii
BSR20180479journal_volume
38pub_type
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journal_title:Bioscience reports
pub_type: 评论,信件
doi:10.1042/BSR20180505
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abstract::Common colds were shortened by 7 days in a 1984 clinical trial using zinc gluconate throat lozenges each 2 h. Between then and 2004, 10 other double-blind, placebo-controlled clinical trials showed widely varying results. This re-analysis of these trials presents solution chemistry methods to elucidate differences in ...
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pub_type: 杂志文章,meta分析
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journal_title:Bioscience reports
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abstract::Non-Small Cell Lung Cancer (NSCLC) is responsible for the majority of deaths caused by cancer. Small C-terminal domain (CTD) phosphatases (SCP), CTDSP1, CTDSP2 and CTDSPL (CTDSPs) belong to SCP/CTDSP subfamily and are involved in many vital cellular processes and tumorigenesis. High similarity of their structures sugg...
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doi:10.1042/BSR20201084
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abstract:BACKGROUND:Breast cancer (BC) is the most common malignancy among females worldwide. The tumor microenvironment usually prevents effective lymphocyte activation and infiltration, and suppresses infiltrating effector cells, leading to a failure of the host to reject the tumor. CC chemokines play a significant role in in...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20202042
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journal_title:Bioscience reports
pub_type: 杂志文章
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20150190
更新日期:2015-10-12 00:00:00
abstract::Neural stem cells (NSCs) transplantation is one of the most promising strategies for the treatment of CA-induced brain damage. The transplanted NSCs could differentiate into new neuron and replace the damaged one. However, the poor survival of NSCs in severe hypoxic condition is the limiting step to make the best use ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181635
更新日期:2019-05-14 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190109
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abstract::Gallbladder cancer (GBC) is a relatively rare but fatal gastrointestinal tumor. The microRNA-33b (miR-33b), a member of miR-33 family, is reported to function as a tumor suppressor in various cancers. Notably, miR-33 was predicted to target CROCC based on microarray-based analysis. Hereby, we aimed to characterize the...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190108
更新日期:2020-01-31 00:00:00
abstract::A novel approach was used to assess the role of phosphoinositide hydrolysis in the mitogenic action of phytohemagglutinin (PHA) or concanavalin A (ConA). The treatment of human peripheral blood leukocytes (PBL) with monospecific antibodies against phospholipase C (PLC) produced a dose-dependent inhibition (up to 100%)...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116866
更新日期:1987-09-01 00:00:00
abstract:AIM:IgA nephropathy (IgAN) is one of the most common chronic glomerulonephritis. Its etiology and pathogenesis remain unclear. We thus explored the immune repertoire of the B-cell receptor (BCR) and the heavy-chain complementarity-determining region 3 (CDR3) in renal tissue and peripheral blood of IgAN patients. METHO...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190482
更新日期:2019-10-30 00:00:00
abstract::A few studies suggested the contribution of PPARs to the etiology of schizophrenia (SCZ). However, it is still not clear whether variants in PPAR-encoding genes have a direct association with SCZ. The potential linkage between SCZ and the variants within PPAR encoding genes (PPARA, PPARD, and PPARG) was tested in a la...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20201083
更新日期:2020-07-31 00:00:00
abstract::The role of the topoisomerase enzyme in DNA recombination was investigated by extracting chromosomal deoxyribonucleoproteins from a variety of cultured mammalian cells and assaying for the formation of recombinant DNA structures. Although each of the crude deoxyribonucleoprotein preparations contained topoisomerase ac...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01115252
更新日期:1982-07-01 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章,meta分析
doi:10.1042/BSR20180161
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01207265
更新日期:1996-10-01 00:00:00
abstract::Brain metastases are the most common intracranial tumors in adults. They usually originate from: lung, breast, renal cell and gastrointestinal cancers, as well as melanoma. Prognosis for brain metastases is still poor and classical treatment combining surgery and radiation therapy should be strongly supported with mol...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180731
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abstract::Kawasaki disease (KD) is a type of disease that includes the development of a fever that lasts at least 5 days and involves the clinical manifestation of multicellular vasculitis. KD has become one of the most common pediatric cardiovascular diseases. Previous studies have reported that miR-218 rs11134527 A>G is assoc...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180367
更新日期:2018-05-22 00:00:00
abstract::Intervertebral disc degeneration is a disease identified as an inflammation response-participated pathological process. As a classical cellular feature, disc cell senescence is reported to be closely related with disc cell senescence. Resveratrol has a protective role against inflammation in some cells. However, its b...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190126
更新日期:2019-05-10 00:00:00
abstract::Erectile dysfunction (ED) is one of the significant complications of diabetes mellitus (DM), and CASR plays an important role in cellular antiapoptosis and NO production in the vascular endothelium by activating PKC. The present study was aimed to investigate the efficacy of Leech and Centipede Granules (LCG) through ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20193845
更新日期:2020-02-28 00:00:00
abstract::The principle of the dual inhibitor titration method for testing models of electron-transport phosphorylation is outlined, and the method is applied to the study of photophosphorylation in bacterial chromatophores. It is concluded that energy coupling is strictly localized in nature in this system, in the sense that f...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01114933
更新日期:1982-10-01 00:00:00
abstract::Background: The present study aimed to evaluate serum 25-hydroxy vitamin D (25(OH) D) levels in Chinese patients with idiopathic benign paroxysmal positional vertigo (BPPV) and to investigate the possible relationship between the occurrence and recurrence of idiopathic BPPV and low 25(OH) D levels. Methods: Between 1 ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190142
更新日期:2019-04-30 00:00:00
abstract::Osteosarcoma is a malignant bone tumour with the lowest survival rates out of all paediatric cancers and is primarily diagnosed in children and adolescents. MNAT1 is a subunit in the cyclin-dependent kinase-activating kinase complex. Abnormal up-regulation of MNAT1 has been associated with the poor prognosis of multip...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20201232
更新日期:2020-06-26 00:00:00
abstract::Extracts from uterine cervical and body cancers, but not from benign tumor or intact tissues tested, were found to contain a growth-promoting activity which induced the proliferation of human endometrial fibroblasts. Exposure of cultured fibroblasts to the cancer extracts increased the rate of [3H]thymidine incorporat...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116850
更新日期:1990-02-01 00:00:00
abstract::Resistance to chemotherapy is one of main obstacles in the treatment of colorectal cancer (CRC). However, the mechanisms are still unclear, and the treatment options are still limited. miR-543 has been indicated to act as an oncogene in some cancers, but its function in regulating chemoresistance has not been consider...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190249
更新日期:2019-03-22 00:00:00
abstract:OBJECTIVES:To investigate the association between dectin-1 gene single nucleotide polymorphisms (SNPs) and susceptibility to fungal infection (FI). METHODS:Databases were searched electronically and manually to identify case-control studies concerning dectin-1 SNPs and FI, which were published up to 12 November 2018. ...
journal_title:Bioscience reports
pub_type: 杂志文章,meta分析
doi:10.1042/BSR20191519
更新日期:2019-11-29 00:00:00