Computational analysis and verification of molecular genetic targets for glioblastoma.

abstract：:An ontogenetic study of the effect of various neurohormones and other activators on adenylate cyclase systems was carried out using cultures of cells from 15-d-old embryonic mouse brain. Dopamine stimulated the enzyme activity at earlier culture ages (i.e. 4 and 10 d) but had little stimulatory effect at later ages (i...

journal_title：Bioscience reports

authors： Shanker G,Pieringer RA

更新日期：1985-07-01 00:00:00

abstract：:To clarify the mechanism of circGOLPH3 regulation on prostate cancer cells, we performed an overexpression and interference circGOLPH3 assay in prostate cancer cells PC-3 and then evaluated cellular viability, proliferation, cell cycle, and apoptosis of prostate cancer cells by MTT, CCK8, Edu stain, TUNEL stain, and f...

journal_title：Bioscience reports

authors： Gong L,Tang Y,Jiang L,Tang W,Luo S

更新日期：2020-12-23 00:00:00

abstract：:Bifunctional dihaem cytochrome c thiosulfate dehydrogenases/tetrathionate reductases (TsdA) exhibit different catalytic properties depending on the source organism. In the human food-borne intestinal pathogen Campylobacter jejuni, TsdA functions as a tetrathionate reductase enabling respiration with tetrathionate as a...

journal_title：Bioscience reports

authors： Kurth JM,Butt JN,Kelly DJ,Dahl C

更新日期：2016-12-09 00:00:00

abstract：:Matrix-bound monoclonal antibodies against urokinase have been used to purify this enzyme by affinity chromatography. In a single-step procedure, urokinase can be isolated from crude preparations with high yield and high purity, and without loss of enzymatic activity. ...

journal_title：Bioscience reports

authors： Hérion P,Bollen A

更新日期：1983-04-01 00:00:00

abstract：:In order to better understand the role of cell surface glycolipids in T lymphocyte activation, heparin was used to simultaneously modulate the expression of glycolipids and the lytic capacity of lymphocytes activated by interleukin-2. Results presented here show that heparin added at the start of a 3 day culture inhib...

journal_title：Bioscience reports

authors： Schwarting GA,Gajewski A

更新日期：1988-08-01 00:00:00

abstract：:Chromosome 14 ORF 166 (C14orf166), a protein involved in the regulation of RNA transcription and translation, has been reported to possess the potency to promote tumorigenesis; however, the role of C14orf166 in non-small-cell lung cancer (NSCLC) remains unknown. The purpose of the present study was to assess C14orf166...

journal_title：Bioscience reports

authors： Zhou YW,Li R,Duan CJ,Gao Y,Cheng YD,Zhang CF

更新日期：2018-09-13 00:00:00

abstract：:Escherichia coli accumulates K+ by means of multiple transport systems, of which TrkA is the most prominent at neutral and alkaline pH while Kup is major at acidic pH. In the present study, K+ uptake was observed with cells grown under fermentative conditions at an initial pH of 9.0 and 7.3 (the medium pH decreased to...

journal_title：Bioscience reports

authors： Trchounian A,Kobayashi H

更新日期：2000-08-01 00:00:00

abstract：:Common colds were shortened by 7 days in a 1984 clinical trial using zinc gluconate throat lozenges each 2 h. Between then and 2004, 10 other double-blind, placebo-controlled clinical trials showed widely varying results. This re-analysis of these trials presents solution chemistry methods to elucidate differences in ...

journal_title：Bioscience reports

authors： Eby GA

更新日期：2004-02-01 00:00:00

abstract：:The preadipocyte differentiation biological process involves a cascade of transcriptional events that culminates in the expression of peroxisome proliferator-activated receptor (PPAR) γ. The differentiation cocktail [insulin (INS), dexamethasone (DEX) and isobutylmethylxanthine (IBMX)] can induce preadipocyte differen...

journal_title：Bioscience reports

authors： Cheng B,Wu M,Xu S,Zhang X,Wang Y,Wang N,Leng L,Li H

更新日期：2016-11-03 00:00:00

abstract：:Chitinases catalyze the degradation of chitin, a ubiquitous polymer generated from the cell walls of fungi, shells of crustaceans, and cuticles of insects. They are gaining increasing attention in medicine, agriculture, food and drug industries, and environmental management. Their roles in the degradation of chitin fo...

journal_title：Bioscience reports

authors： Oyeleye A,Normi YM

更新日期：2018-08-29 00:00:00

abstract：:Cervical carcinoma is the most common gynecological cancer in women worldwide. Emerging evidence has shown that long non-coding RNAs (lncRNAs) participate in multiple biological processes of cervical carcinoma tumorigenesis. We aimed to investigate the function of a novel lncRNA RP11-284F21.9 in cervical carcinoma. We...

journal_title：Bioscience reports

authors： Han HF,Chen Q,Zhao WW

更新日期：2020-09-30 00:00:00

abstract：:To explore the effect and mechanism of LncRNA LUCAT1 in cervical cancer (CC). In the present study, 67 cases of CC patients and 60 healthy cases were selected as the research objects. CC patients were selected as the study group (SG) and healthy physical examination patients were selected as the control group (CG). LU...

journal_title：Bioscience reports

authors： Yang T,Xia S

更新日期：2020-04-30 00:00:00

abstract：:The present study describes the enzymatic properties and molecular identification of 5'-nucleotidase in soluble and microsomal fractions from rat cardiac ventricles. Using AMP as a substrate, the results showed that the cation and the concentration required for maximal activity in the two fractions was magnesium at a ...

journal_title：Bioscience reports

authors： Pochmann D,Innocente AM,Cotomacci G,Barreto-Chaves ML,Sarkis JJ

更新日期：2008-10-01 00:00:00

abstract：:Recent developments in the study of peptide amidation are reviewed. The main areas covered are assay procedures, purification of amidating enzymes, co-factors and regulation, mechanism and specificity of the amidating reaction, and multiple forms of the amidating enzyme and glycosylation. Discussion is presented on as...

journal_title：Bioscience reports

authors： Bradbury AF,Smyth DG

更新日期：1987-12-01 00:00:00

abstract：:Mitochondrial disorders encompass any medical specialty and affect patients at any age. Likewise, the spectrum of clinical and genetic signatures of these disorders is ample, making a precise diagnosis difficult. We will report some of the major clinical phenotypes observed in infancy, their underlining molecular feat...

journal_title：Bioscience reports

authors： Carrozzo R,Piemonte F,Tessa A,Lucioli S,Rizza T,Meschini MC,Fattori F,Santorelli FM

更新日期：2007-06-01 00:00:00

abstract：:Abnormal aggregation of pathological tau protein is a neuropathological feature of Alzheimer's disease (AD). In the AD patients, the abnormal tau accumulation first appeared in entorhinal cortex (EC) and then propagated to the hippocampus with microglia activation and inflammation, but the mechanism is elusive. Here, ...

journal_title：Bioscience reports

authors： Liu Y,Zhang S,Li X,Liu E,Wang X,Zhou Q,Ye J,Wang JZ

更新日期：2020-02-28 00:00:00

abstract：:Alterations in genomic CpG methylation patterns have been found to be associated with cell transformation and neoplasia. Although it is recognized that methylation of CpG residues negatively regulates gene expression, how the various MBPs (methyl-binding proteins) contribute to this process remains elusive. To determi...

journal_title：Bioscience reports

authors： Yaqinuddin A,Abbas F,Naqvi SZ,Bashir MU,Qazi R,Qureshi SA

更新日期：2008-12-01 00:00:00

abstract：:Purpose: Wilson's disease (WD) is a genetic disorder of copper metabolism with pathological copper accumulation in the brain. The purpose of the present study was to evaluate the relationship between the damaged white matter and the impaired cognitive function in WD patients. Materials and methods: Thirty WD adolescen...

journal_title：Bioscience reports

authors： Dong T,Yang WM,Wu MC,Zhang J,Huang P,Xu CS,Wang AQ,Kuang CJ,Gao ZL

更新日期：2019-03-15 00:00:00

abstract：:Heterotopic ossification (HO) is the aberrant formation of mature, lamellar bone in nonosseous tissue. Fibrodysplasia ossificans progressiva (FOP) is a rare and devastating genetic disorder that causes progressive HO in the ligaments, tendons, and muscles throughout the body. FOP is attributed to an autosomal mutation...

journal_title：Bioscience reports

authors： Lin H,Shi F,Gao J,Hua P

更新日期：2019-08-02 00:00:00

abstract：:Liver cancer is now one of the most lethal and commonest cancers in the world, among which over 90% is hepatocellular carcinoma (HCC). Recent studies have confirmed long non-coding RNAs (lncRNAs) are implicated in carcinogenesis. It has been reported lncRNA LINC00668 serves as an oncogene in several cancers. However, ...

journal_title：Bioscience reports

authors： Xuan W,Zhou C,You G

更新日期：2020-05-29 00:00:00

abstract：:The high proliferation rate of tumor cells demands high energy and metabolites that are sustained by a high glycolytic flux known as the 'Warburg effect'. The activation and further metabolism of glucose is initiated by hexokinase, a focal point of metabolic regulation. The human hexokinase 2 (HK2) is overexpressed in...

journal_title：Bioscience reports

authors： Nawaz MH,Ferreira JC,Nedyalkova L,Zhu H,Carrasco-López C,Kirmizialtin S,Rabeh WM

更新日期：2018-02-21 00:00:00

abstract：:Cardiac hypertrophy is a compensatory response to stress or stimuli, which results in arrhythmia and heart failure. Although multiple molecular mechanisms have been identified, cardiac hypertrophy is still difficult to treat. Pyroptosis is a caspase-1 dependent pro-inflammatory programmed cell death. Caspase-1 is invo...

journal_title：Bioscience reports

authors： Bai Y,Sun X,Chu Q,Li A,Qin Y,Li Y,Yue E,Wang H,Li G,Zahra SM,Dong C,Jiang Y

更新日期：2018-02-12 00:00:00

abstract：:Background: As one of the most common liver disorders worldwide, non-alcoholic fatty liver disease (NAFLD) begins with the abnormal accumulation of triglyceride (TG) in the liver. Long non-coding RNA-H19 was reported to modulate hepatic metabolic homeostasis in NAFLD. However, its molecular mechanism of NAFLD was not ...

journal_title：Bioscience reports

authors： Liu J,Tang T,Wang GD,Liu B

更新日期：2019-07-15 00:00:00

abstract：:Members of the ADAM (a disintegrin and metalloproteinase) family of proteins possess a multidomain architecture which permits functionalities as adhesion molecules, signalling intermediates and proteolytic enzymes. ADAM8 is found on immune cells and is induced by multiple pro-inflammatory stimuli suggesting a role in ...

journal_title：Bioscience reports

authors： Hall T,Leone JW,Wiese JF,Griggs DW,Pegg LE,Pauley AM,Tomasselli AG,Zack MD

更新日期：2009-08-01 00:00:00

abstract：:Ca-ATPase activity in sarcoplasmic reticulum (SR) membranes isolated from skeletal muscles of the typical hibernator, the ground squirrel Spermophilus undulatus, is about 2-fold lower than that in SR membranes of rats and rabbits and is further decreased 2-fold during hibernation. The use of carbocyanine anionic dye S...

journal_title：Bioscience reports

authors： Malysheva AN,Storey KB,Lopina OD,Rubtsov AM

更新日期：2001-12-01 00:00:00

abstract：:Neural stem cells (NSCs) transplantation is one of the most promising strategies for the treatment of CA-induced brain damage. The transplanted NSCs could differentiate into new neuron and replace the damaged one. However, the poor survival of NSCs in severe hypoxic condition is the limiting step to make the best use ...

journal_title：Bioscience reports

authors： Li F,Wei H,Li H,Li X,Hu C,Zhang J,Deng Y,Liao X

更新日期：2019-05-14 00:00:00

abstract：:NUF2 (NUF2, Ndc80 kinetochore complex component) plays an important role in kinetochore-microtubule attachment. It has been reported that NUF2 is associated with multiple human cancers. However, the functional role of NUF2 in pancreatic cancer remains unclear. In this study, we found that NUF2 expression was stronger ...

journal_title：Bioscience reports

authors： Hu P,Chen X,Sun J,Bie P,Zhang LD

更新日期：2015-01-14 00:00:00

abstract：:Choroideremia is a complex form of blindness-causing retinal degeneration. The aim of the present study was to investigate the pathogenic variant and molecular etiology associated with choroideremia in a Chinese family. All available family members underwent detailed ophthalmological examinations. Whole exome sequenci...

journal_title：Bioscience reports

authors： Dan H,Li T,Lei X,Huang X,Xing Y,Shen Y

更新日期：2020-05-29 00:00:00

abstract：BACKGROUND:Polycystic ovarian syndrome (PCOS) is a kind of common gynecological endocrine disorder. And the mutations of melatonin receptor (MTNR) genes are related to the occurrence of PCOS. But previous researches have shown opposite results. So, the object of our systematic review and meta-analysis is to investigate...

journal_title：Bioscience reports

authors： Yi S,Xu J,Shi H,Li W,Li Q,Sun YP

更新日期：2020-06-26 00:00:00

abstract：:Previous studies demonstrated that the adaptive response to stressors and inflammatory signals involves the activation of the autonomous [corrected] nervous system. Catecholamines have been shown to modulate the activity of various immune effector cells directly via membrane adrenergic receptors. Here, we investigated...

journal_title：Bioscience reports

authors： Lünemann JD,Buttgereit F,Tripmacher R,Baerwald CG,Burmester GR,Krause A

更新日期：2001-10-01 00:00:00