Disorders of nuclear-mitochondrial intergenomic communication.

Abstract:

:In the course of evolution, mitochondria lost their independence, and mtDNA became "slave" of nDNA, depending on numerous nucleus-encoded factors for its integrity, replication and expression. Mutations in any of these factors may alter the cross-talk between the two genomes and cause diseases that affect mtDNA integrity or expression, being inherited as mendelian traits.

journal_name

Biosci Rep

journal_title

Bioscience reports

authors

Spinazzola A,Zeviani M

doi

10.1007/s10540-007-9036-1

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

39-51

issue

1-3

eissn

0144-8463

issn

1573-4935

journal_volume

27

pub_type

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