Protein arrays in functional genome research.

abstract：:The effect that research on dopamine and other neutro trasmitters has on disciplines like neurology and psychiatry is described. ...

journal_title：Bioscience reports

authors： Carlsson A

更新日期：2001-12-01 00:00:00

abstract：:Calpain-1 and calpain-2 are highly structurally similar isoforms of calpain. The calpains, a family of intracellular cysteine proteases, cleave their substrates at specific sites, thus modifying their properties such as function or activity. These isoforms have long been considered to function in a redundant or comple...

journal_title：Bioscience reports

authors： Shinkai-Ouchi F,Shindo M,Doi N,Hata S,Ono Y

更新日期：2020-11-27 00:00:00

abstract：:The human bronchial epithelial cell line, 16HBE14o- (16HBE), is widely used as a model for respiratory epithelial diseases and barrier function. During differentiation, transepithelial electrical resistance (TER) increased to approximately 800 Ohms × cm2, while 14C-d-mannitol flux rates (Jm) simultaneously decreased. ...

journal_title：Bioscience reports

authors： Callaghan PJ,Ferrick B,Rybakovsky E,Thomas S,Mullin JM

更新日期：2020-10-30 00:00:00

abstract：:NOX (NADPH oxidase) plays an important role during several pathologies because it produces the superoxide anion (O2•-), which reacts with NO (nitric oxide), diminishing its vasodilator effect. Although different isoforms of NOX are expressed in ECs (endothelial cells) of blood vessels, the NOX2 isoform has been consid...

journal_title：Bioscience reports

authors： Macías-Pérez ME,Martínez-Ramos F,Padilla-Martínez II,Correa-Basurto J,Kispert L,Mendieta-Wejebe JE,Rosales-Hernández MC

更新日期：2013-08-02 00:00:00

abstract：:Since the Protein Data Bank (PDB) was founded in 1971, there are now over 120,000 depositions, the majority of which are from X-ray crystallography and 90% of those made use of synchrotron beamlines. At the Cambridge Structure Database (CSD), founded in 1965, there are more than 800,000 'small molecule' crystal struct...

journal_title：Bioscience reports

authors： Helliwell JR

更新日期：2017-07-04 00:00:00

abstract：:NUF2 (NUF2, Ndc80 kinetochore complex component) plays an important role in kinetochore-microtubule attachment. It has been reported that NUF2 is associated with multiple human cancers. However, the functional role of NUF2 in pancreatic cancer remains unclear. In this study, we found that NUF2 expression was stronger ...

journal_title：Bioscience reports

authors： Hu P,Chen X,Sun J,Bie P,Zhang LD

更新日期：2015-01-14 00:00:00

abstract：:A new method for detecting viral antibodies in cerebrospinal fluid is described. The technique has many advantages over previously published methods in that it is highly sensitive eliminating the need to concentrate the CSF, takes 5 h to complete, avoids the use of radionucleides, and most importantly circumvents prob...

journal_title：Bioscience reports

authors： Moyle S,Keir G,Thompson EJ

更新日期：1984-06-01 00:00:00

abstract：:Cell membranes have important functions in many steps of the blood coagulation cascade, including the activation of factor X (FX) by the factor VIIa (FVIIa)-tissue factor (TF) complex (extrinsic Xase). FVIIa shares structural similarity with factor IXa (FIXa) and FXa. FIXa and FXa are regulated by binding to phosphati...

journal_title：Bioscience reports

authors： Sengupta T,Koklic T,Lentz BR,Majumder R

更新日期：2021-01-22 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) is the most common cancer in children, and alterations in CDKN2A were considered to play an important role on leukemogenesis. Two single nucleotide polymorphisms (SNPs) at CDKN2A locus were identified to impact on ALL susceptibility via genome wide association studies, and followed b...

journal_title：Bioscience reports

authors： Zhou X,Liao F,Zhang J,Qin Y,Xu H,Ding Z,Zhang Y,Zhang F

更新日期：2018-06-27 00:00:00

abstract：BACKGROUND:Glioma is the most common malignant tumor in the human central nervous system. Long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) promotes oncogenesis in various tumors. In the present study, we aimed to examine the role of NEAT1 in altering the properties of gliomas. METHODS:Quantitative ...

journal_title：Bioscience reports

authors： Li Y,Wang X,Zhao Z,Shang J,Li G,Zhang R

更新日期：2021-01-04 00:00:00

abstract：:Canstatin, the non-collagenous domain of collagen type IV α-chains, belongs to a series of collagen-derived angiogenic inhibitors. In this study, the inhibitory effect of recombinant canstatin on tumour growth was investigated using a gastric cancer xenograft model. The volume and weight of tumours in mice treated wit...

journal_title：Bioscience reports

authors： Xing YN,Deng P,Xu HM

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Glioblastoma (GBM) is the most common malignant brain tumor with a poor prognosis. The initial treatment for high-grade gliomas is surgical excision. However, even with concomitant use of radiation or chemotherapy, patients are still prone to recurrence. The specific pathogenesis of GBM is still controversia...

journal_title：Bioscience reports

authors： Xue L,Liu H,Chen Y,Wei L,Hong J

更新日期：2020-06-26 00:00:00

abstract：:Levels of red cell, serum acid, and alkaline phosphatases, serum amylase, alanine and aspartate transferase and bilirubin were examined in streptozotocin-induced diabetic rats treated with garlic oil and compared with the corresponding levels in diabetic control rats, normal rats and normal rats on garlic oil. Values ...

journal_title：Bioscience reports

authors： Ohaeri OC

更新日期：2001-02-01 00:00:00

abstract：:Emerging evidence are accumulating that long noncoding RNAs (lncRNAs) have recently been identified to participate in various cellular processes. Terminal differentiation induced ncRNA (TINCR) is a newly identified lncRNA with its functional roles not fully elucidated in human malignancy. The current study aims to ide...

journal_title：Bioscience reports

authors： Tian F,Xu J,Xue F,Guan E,Xu X

更新日期：2017-07-27 00:00:00

abstract：:A novel approach was used to assess the role of phosphoinositide hydrolysis in the mitogenic action of phytohemagglutinin (PHA) or concanavalin A (ConA). The treatment of human peripheral blood leukocytes (PBL) with monospecific antibodies against phospholipase C (PLC) produced a dose-dependent inhibition (up to 100%)...

journal_title：Bioscience reports

authors： Moraru II,Manciulea M,Călugăru A,Ghyka G,Popescu LM

更新日期：1987-09-01 00:00:00

abstract：:Objective: We aimed to assess the possible relations between serum levels of macrophage migration inhibitory factor (MIF), a central cytokine of the innate immunity and inflammatory response, and benign paroxysmal positional vertigo (BPPV) risk and BPPV recurrence events.Methods: In the present study, 154 patients wit...

journal_title：Bioscience reports

authors： Cai HB,Duan L,Tian T,Li ZC,Zhao CC,Ge ZM

更新日期：2019-08-23 00:00:00

abstract：:Particulate membrane fractions from calf liver catalyze the release of glucose from GlcNAc2-Man9-Glc1-3-oligosaccharides. Maximal oligosaccharide-glucosidase activity was obtained at pH 6.2 and a detergent concentration of 0.5% Triton X-100. This activity could be distinguished from non-specific alpha-glucosidase acti...

journal_title：Bioscience reports

authors： Hettkamp H,Bause E,Legler G

更新日期：1982-11-01 00:00:00

abstract：:A possible role for Ca2+ and calmodulin in the action of growth-hormone-releasing factor (GHRF) was investigated. Low extracellular Ca2+ (less than 100 microM), methoxyverapamil, flunarizine, cinnarizine, and Co2+ decreased both basal and GHRF-stimulated growth-hormone secretion, but did not totally inhibit GHRF-stimu...

journal_title：Bioscience reports

authors： Merritt JE,Dobson PR,Wojcikiewicz RJ,Baird JG,Brown BL

更新日期：1984-12-01 00:00:00

abstract：:FAH domain containing protein 1 (FAHD1) is a mammalian mitochondrial protein, displaying bifunctionality as acylpyruvate hydrolase (ApH) and oxaloacetate decarboxylase (ODx) activity. We report the crystal structure of mouse FAHD1 and structural mapping of the active site of mouse FAHD1. Despite high structural simila...

journal_title：Bioscience reports

authors： Weiss AKH,Naschberger A,Cappuccio E,Metzger C,Mottes L,Holzknecht M,von Velsen J,Bowler MW,Rupp B,Jansen-Dürr P

更新日期：2020-03-27 00:00:00

abstract：OBJECTIVE:To observe the restraining effect of IL-38 on inflammatory response in collagen-induced arthritis rats (CIA), and to explore the regulatory mechanism of SIRT1/HIF-1α signaling pathway. METHODS:40 SD rats were randomly divided into Control group, CIA group, CLL group and CLH group, with 10 rats in each group;...

journal_title：Bioscience reports

authors： Pei B,Chen K,Zhou S,Min D,Xiao W

更新日期：2020-05-29 00:00:00

abstract：:Extracorporeal pulsed electromagnetic field (PEMF) has shown the ability to regenerate tissue by promoting cell proliferation. In the present study, we investigated for the first time whether PEMF treatment could improve the myocardial ischaemia/reperfusion (I/R) injury and uncovered its underlying mechanisms.In our s...

journal_title：Bioscience reports

authors： Ma F,Li W,Li X,Tran BH,Suguro R,Guan R,Hou C,Wang H,Zhang A,Zhu Y,Zhu Y

更新日期：2016-12-05 00:00:00

abstract：:Gallbladder cancer (GBC) is a relatively rare but fatal gastrointestinal tumor. The microRNA-33b (miR-33b), a member of miR-33 family, is reported to function as a tumor suppressor in various cancers. Notably, miR-33 was predicted to target CROCC based on microarray-based analysis. Hereby, we aimed to characterize the...

journal_title：Bioscience reports

authors： Xu G,Wei X,Tu Q,Zhou C

更新日期：2020-01-31 00:00:00

abstract：:C3G (Crk SH3-domain-binding guanine-nucleotide-releasing factor) is a ubiquitously expressed member of a class of molecules called GEFs (guanine-nucleotide-exchange factor) that activate small GTPases and is involved in pathways triggered by a variety of signals. It is essential for mammalian embryonic development and...

journal_title：Bioscience reports

authors： Radha V,Mitra A,Dayma K,Sasikumar K

更新日期：2011-08-01 00:00:00

abstract：:Prefoldin subunits (PFDN), primarily known for co-chaperone function associated with cytoskeletal rearrangement, have been found involved in epithelial-mesenchymal transition (EMT) and cancer progression. However, studies focusing on the roles of PFDN in gastric cancer (GC) remain limited. The present study aims to ev...

journal_title：Bioscience reports

authors： Yesseyeva G,Aikemu B,Hong H,Yu C,Dong F,Sun J,Zang L,Zheng M,Ma J

更新日期：2020-02-28 00:00:00

abstract：:Recent developments in the study of peptide amidation are reviewed. The main areas covered are assay procedures, purification of amidating enzymes, co-factors and regulation, mechanism and specificity of the amidating reaction, and multiple forms of the amidating enzyme and glycosylation. Discussion is presented on as...

journal_title：Bioscience reports

authors： Bradbury AF,Smyth DG

更新日期：1987-12-01 00:00:00

abstract：:Cryptococcus neoformans is an opportunistic fungal pathogen that causes life-threatening meningitis primarily in immunocompromised individuals. In order to survive and proliferate during infection, C. neoformans must adapt to a variety of stresses it encounters within the host. Patient outcome depends on the interacti...

journal_title：Bioscience reports

authors： Altamirano S,Jackson KM,Nielsen K

更新日期：2020-10-30 00:00:00

abstract：:Background: Selenoprotein S (SelS) gene expression is positively correlated to triglyceride (TG) concentrations and is associated with diabetes in animal model. However, the relationship between genetic polymorphisms of SelS and Type 2 diabetes (T2DM) remains unclear. Methods: In the present study, we genotyped four s...

journal_title：Bioscience reports

authors： Zhao L,Zheng YY,Chen Y,Ma YT,Yang YN,Li XM,Ma X,Xie X

更新日期：2018-11-28 00:00:00

abstract：:Due to poor prognosis of glioblastoma (GBM), there is an urgent need to develop new therapeutic strategies. Besides eliminating GBM tumor cells and stem cells, a novel therapeutic approach aims to target Glioma-associated microglia/macrophages (GAMs). We investigated the molecular profile of GAMs correlated with patie...

journal_title：Bioscience reports

authors： Gjorgjevski M,Hannen R,Carl B,Li Y,Landmann E,Buchholz M,Bartsch JW,Nimsky C

更新日期：2019-06-20 00:00:00

abstract：:Chemical and physical stimuli trigger a cutaneous response by first inducing the main epidermal cells, keratinocytes, to produce specific mediators that are responsible for the initiation of skin inflammation. Activation modulates cell communication, namely leucocyte recruitment and blood-to-skin extravasation through...

journal_title：Bioscience reports

authors： Franchi J,Marteau C,Crola da Silva C,Mitterrand M,André P,Kieda C

更新日期：2008-02-01 00:00:00

abstract：:Carnosic acid (CA), a major polyphenolic diterpene present in Rosmarinus officinalis, has been reported to have multiple functions, including antitumor activity. The MTT assay, BrdU incorporation, wound healing, and colony formation were used to detect melanoma B16F10 cell growth and proliferation. Flow cytometry was ...

journal_title：Bioscience reports

authors： Lin KI,Lin CC,Kuo SM,Lai JC,Wang YQ,You HL,Hsu ML,Chen CH,Shiu LY

更新日期：2018-07-02 00:00:00