Abstract:
:Extracorporeal pulsed electromagnetic field (PEMF) has shown the ability to regenerate tissue by promoting cell proliferation. In the present study, we investigated for the first time whether PEMF treatment could improve the myocardial ischaemia/reperfusion (I/R) injury and uncovered its underlying mechanisms.In our study, we demonstrated for the first time that extracorporeal PEMF has a novel effect on myocardial I/R injury. The number and function of circulating endothelial progenitor cells (EPCs) were increased in PEMF treating rats. The in vivo results showed that per-treatment of PEMF could significantly improve the cardiac function in I/R injury group. In addition, PEMF treatment also reduced the apoptosis of myocardial cells by up-regulating the expression of anti-apoptosis protein B-cell lymphoma 2 (Bcl-2) and down-regulating the expression of pro-apoptosis protein (Bax). In vitro, the results showed that PEMF treatment could significantly reduce the apoptosis and reactive oxygen species (ROS) levels in primary neonatal rat cardiac ventricular myocytes (NRCMs) induced by hypoxia/reoxygenation (H/R). In particular, PEMF increased the phosphorylation of protein kinase B (Akt) and endothelial nitric oxide synthase (eNOS), which might be closely related to attenuated cell apoptosis by increasing the releasing of nitric oxide (NO). Therefore, our data indicated that PEMF could be a potential candidate for I/R injury.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Ma F,Li W,Li X,Tran BH,Suguro R,Guan R,Hou C,Wang H,Zhang A,Zhu Y,Zhu Ydoi
10.1042/BSR20160082subject
Has Abstractpub_date
2016-12-05 00:00:00issue
6eissn
0144-8463issn
1573-4935pii
BSR20160082journal_volume
36pub_type
杂志文章abstract::Resistance to chemotherapy is one of main obstacles in the treatment of colorectal cancer (CRC). However, the mechanisms are still unclear, and the treatment options are still limited. miR-543 has been indicated to act as an oncogene in some cancers, but its function in regulating chemoresistance has not been consider...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190249
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journal_title:Bioscience reports
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116191
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01201001
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abstract::Microparticles (MPs) and miRNAs have been shown to play important roles in coronary artery disease (CAD) by monitoring endothelial dysfunction. The present study aims to investigate the diagnostic value of endothelial MPs (EMPs) and miRNAs (miR-92a or miR-23a) as biomarkers in distinguishing patients with acute myocar...
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journal_title:Bioscience reports
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20160122
更新日期:2016-06-30 00:00:00
abstract::High-affinity binding of 3H-folate in Triton X-100 solubilized membranes of human liver displayed characteristics, e.g. apparent positive cooperativity, which are typical of specific folate binding. Ultrogel AcA 44 chromatography of solubilized membranes saturated with 3H-folate revealed a major peak of 100 kDa and a ...
journal_title:Bioscience reports
pub_type: 杂志文章
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journal_title:Bioscience reports
pub_type: 杂志文章
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更新日期:2017-12-12 00:00:00
abstract::The large size of a 1.5-MDa ice-binding adhesin [MpAFP (Marinomonas primoryensis antifreeze protein)] from an Antarctic Gram-negative bacterium, M. primoryensis, is mainly due to its highly repetitive RII (Region II). MpAFP_RII contains roughly 120 tandem copies of an identical 104-residue repeat. We have previously d...
journal_title:Bioscience reports
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doi:10.1042/BSR20140083
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20100084
更新日期:2011-06-01 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1023/a:1026493024066
更新日期:2000-08-01 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190224
更新日期:2019-05-03 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181074
更新日期:2019-01-15 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190108
更新日期:2020-01-31 00:00:00
abstract:OBJECTIVE:The role of lncRNAs in tumor has been widely concerned. The present study took HAS2-AS1 (the antisense RNA 1 of HAS2) as a starting point to explore its expression in glioma and its role in the process of migration and invasion, providing a strong theoretical basis for mining potential therapeutic targets of ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20200487
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journal_title:Bioscience reports
pub_type: 杂志文章
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01204353
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journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1023/a:1017939725776
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journal_title:Bioscience reports
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doi:10.1007/BF01855015
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01114973
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journal_title:Bioscience reports
pub_type: 传,历史文章
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abstract::Partitioning in charge-sensitive dextran-poly(ethylene glycol) aqueous phase systems reveals that fixation with even small concentrations of glutaraldehyde (e.g., 0.1% w/v) changes the surface properties of cells. While fixation with larger concentrations of glutaraldehyde (i.e., 1.85%) increases erythrocyte partition...
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