Abstract:
:Microparticles (MPs) and miRNAs have been shown to play important roles in coronary artery disease (CAD) by monitoring endothelial dysfunction. The present study aims to investigate the diagnostic value of endothelial MPs (EMPs) and miRNAs (miR-92a or miR-23a) as biomarkers in distinguishing patients with acute myocardial infarction (AMI) from those with CAD. Plasma samples from 37 patients with AMI, 42 patients with stable CAD (SCAD), and 35 healthy adults were collected for investigation in the present study. The numbers of CD31+/CD42b- MPs, CD31+/CD42b+ MPs, and CD31-/CD42b- MPs were measured by flow cytometry and the levels of miR-92a and miR-23a were analyzed using reverse transcription-quantitative PCR. Moreover, cardiac troponin I (cTnI) expression was detected by ELISA to serve as a routine diagnostic parameter. The number of CD31+/CD42b- was higher in AMI group than those in SCAD and healthy groups. Besides, the expression of miR-92a was higher in AMI group compared with two other groups. Furthermore, evidence showed that there was a positive correlation between the levels of CD31+/CD42b- MPs and miR-92a Finally, the receiver operating characteristic (ROC) curve revealed that the area value under the curve of CD31+/CD42b- MPs, miR-92a and cTnI was 0.893, 0.888, and 0.912 respectively. CD31+/CD42b- MPs and miR-92a might have great potential to provide diagnostic value for AMI and could probably regulate the endothelial dysfunction in AMI patients.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Zhang Y,Cheng J,Chen F,Wu C,Zhang J,Ren X,Pan Y,Nie B,Li Q,Li Ydoi
10.1042/BSR20170047subject
Has Abstractpub_date
2017-03-27 00:00:00issue
2eissn
0144-8463issn
1573-4935pii
BSR20170047journal_volume
37pub_type
杂志文章abstract::Brain metastases are the most common intracranial tumors in adults. They usually originate from: lung, breast, renal cell and gastrointestinal cancers, as well as melanoma. Prognosis for brain metastases is still poor and classical treatment combining surgery and radiation therapy should be strongly supported with mol...
journal_title:Bioscience reports
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abstract::Calpain-1 and calpain-2 are highly structurally similar isoforms of calpain. The calpains, a family of intracellular cysteine proteases, cleave their substrates at specific sites, thus modifying their properties such as function or activity. These isoforms have long been considered to function in a redundant or comple...
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abstract::The sodium contents of beta-cell-rich pancreatic islets from ob/ob-mice were measured with an integrating flame photometer. After washing to an apparent steady state with different types of ice-cold media, islets incubated in the absence of glucose contained 79-108 mmol sodium kg-1 dry weight. Exposure to glucose resu...
journal_title:Bioscience reports
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pub_type: 杂志文章,meta分析
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journal_title:Bioscience reports
pub_type: 杂志文章,评审
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journal_title:Bioscience reports
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journal_title:Bioscience reports
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更新日期:1987-01-01 00:00:00
abstract::Two established cancer cell lines, MCF-7 and Ishikawa, were both obtained directly from a cell repository and through another laboratory. The karyotypes from the two MCF-7 cell lines had up to 83 chromosomes and similarities for chromosomal gain and structural abnormalities. The two Ishikawa cell lines had up to 60 ch...
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doi:10.1007/s10540-005-2797-5
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doi:10.1042/BSR20190100
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01140663
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journal_title:Bioscience reports
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journal_title:Bioscience reports
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doi:10.1007/BF01116904
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journal_title:Bioscience reports
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journal_title:Bioscience reports
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journal_title:Bioscience reports
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journal_title:Bioscience reports
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journal_title:Bioscience reports
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abstract::Immobilization of yeast mitochondrial RNA on nitrocellulose filters without prior alkali treatment revealed a low-MW RNA species (integral of 300 bases) which hybridizes specifically to the RNA coding strand of a DNA fragment BglII-HinfI at the 3' end of the COB-BOX gene. This RNA species (often a doublet) was found i...
journal_title:Bioscience reports
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journal_title:Bioscience reports
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更新日期:2020-12-01 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180131
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