Abstract：
:Carnosic acid (CA), a major polyphenolic diterpene present in Rosmarinus officinalis, has been reported to have multiple functions, including antitumor activity. The MTT assay, BrdU incorporation, wound healing, and colony formation were used to detect melanoma B16F10 cell growth and proliferation. Flow cytometry was used for cell cycle detection. p21 and p27 expression was detected by Western blotting. B16F10 cell xenograft model was established, and treated with CA, carmustine (BCNU), or lomustine (CCNU). The present study found that CA exhibits significant growth inhibition and cell cycle arrest in melanoma B16F10 cells. We also found that CA triggers cell cycle arrest at G0/G1 phase, and enhances p21 expression. Additionally, CA can enhance BCNU- and CCNU-mediated cytotoxicity and cell cycle arrest in B16F10 cells. Finally, we found that CA inhibits tumor growth, and reduces the values of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in vivo The present study study concluded that CA may be safe and useful as a novel chemotherapeutic agent.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Lin KI,Lin CC,Kuo SM,Lai JC,Wang YQ,You HL,Hsu ML,Chen CH,Shiu LYdoi
10.1042/BSR20180005subject
Has Abstractpub_date
2018-07-02 00:00:00issue
4eissn
0144-8463issn
1573-4935pii
BSR20180005journal_volume
38pub_type
杂志文章abstract：:We assessed the relationship between the volume of epicardial adipose tissue and long-term outcomes in patients with coronary heart disease (CHD) undergoing percutaneous coronary intervention (PCI). The patients with CHD were followed for at least 2 years after PCI. The epicardial adipose tissue volume (EATV) was meas...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20182278
更新日期：2019-05-07 00:00:00
abstract：:Intracellular lipid-binding proteins (iLBPs) of the fatty acid-binding protein (FABP) family of animals transport, mainly fatty acids or retinoids, are confined to the cytosol and have highly similar 3D structures. In contrast, nematodes possess fatty acid-binding proteins (nemFABPs) that are secreted into the perivit...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20191292
更新日期：2019-07-23 00:00:00
abstract：:Amphiphilic anionic peptides have been used to enhance the efficiency of transfection by helping plasmids to escape from endosomes to the cytosol. It has been shown that efficiency of an eicosamers containing five glutamyl residues (E5), can be considerably enhanced either by transforming it into a dimer or by adding ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1023/a:1010382001654
更新日期：2000-10-01 00:00:00
abstract：:Isolated mouse pancreatic islets were infected in vitro with two strains of Coxsackie B4 virus--a tissue culture-adapted strain and a mouse pancreas-adapted strain. Within 48 h of infection changes had occurred in the biochemical activities of islets infected with the mouse pancreas-adapted strain of virus. Basal insu...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01117442
更新日期：1985-01-01 00:00:00
abstract：:Background: Nasopharyngeal carcinoma (NPC) is a disease highly sensitive to radiotherapy with the unclear etiology. However, the specific effects of microRNA-613 (miR-613) on NPC still remain elusive. Therefore, the present study probes into the underlying mechanism of miR-613 in NPC via AKT signaling pathway by regul...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20182196
更新日期：2019-07-10 00:00:00
abstract：:The present study investigated the effects of Isorhamnetin on two types of prostate cancer cells (androgen-independent and androgen-dependent) and explored its possible mechanisms underlying such effects. Treatment with Isorhamnetin significantly inhibited cell growth and induced lactate dehydrogenase (LDH) release of...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20192826
更新日期：2020-03-27 00:00:00
abstract：:Bladder cancer is a common malignant tumour worldwide. Epithelial-mesenchymal transition (EMT)-related biomarkers can be used for early diagnosis and prognosis of cancer patients. To explore, accurate prediction models are essential to the diagnosis and treatment for bladder cancer. In the present study, an EMT-relate...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20203944
更新日期：2021-01-29 00:00:00
abstract：:The exon junction complex (EJC) is the main mechanism by which cells select specific mRNAs for translation into protein. We hypothesized that the EJC is involved in the regulation of gene expression during the stress response in cardiac myocytes, with implications for the failing heart. In cultured rat neonatal myocyt...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20170707
更新日期：2017-07-07 00:00:00
abstract：:microRNAs (miRNAs) have been found to affect various cancers, and expression of numerous miRNAs is revealed in glioma. However, the role of microRNA-30b-3p (miR-30b-3p) in glioma remains elusive. Therefore, the present study aims to explore the specific mechanism by which miR-30b-3p influence the development of glioma...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20182226
更新日期：2019-08-13 00:00:00
abstract：:The affinity of epigallocatechin gallate (EGCG) for human serum albumin (HSA) was measured in physiological conditions using NMR and isothermal titration calorimetry (ITC). NMR estimated the Ka (self-dissociation constant) of EGCG as 50 mM. NMR showed two binding events: strong (n1=1.8 ± 0.2; Kd1 =19 ± 12 μM) and weak...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20170209
更新日期：2017-05-11 00:00:00
abstract：:In India, Sorghum plant allergenicity was reported to be approximately 54.9%. Sorghum bicolor Polcalcin (Sorb PC) was identified as the panallergen but the specificity of this allergen is yet to be characterized. The present study was aimed to characterize the antigenic determinants of Sorb PC that are responsible for...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20191835
更新日期：2019-11-29 00:00:00
abstract：BACKGROUND:Annulus fibrosus (AF) is important to confine disc nucleus pulposus (NP) tissue during mechanical load experience. However, the knowledge on AF cell biology under mechanical load is much limited compared with disc NP. OBJECTIVE:The present study aimed to investigate responses of apoptosis and matrix metabol...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20182375
更新日期：2019-02-22 00:00:00
abstract：:High-affinity binding of 3H-folate in Triton X-100 solubilized membranes of human liver displayed characteristics, e.g. apparent positive cooperativity, which are typical of specific folate binding. Ultrogel AcA 44 chromatography of solubilized membranes saturated with 3H-folate revealed a major peak of 100 kDa and a ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01182482
更新日期：1991-06-01 00:00:00
abstract：:An ontogenetic study of the effect of various neurohormones and other activators on adenylate cyclase systems was carried out using cultures of cells from 15-d-old embryonic mouse brain. Dopamine stimulated the enzyme activity at earlier culture ages (i.e. 4 and 10 d) but had little stimulatory effect at later ages (i...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01117073
更新日期：1985-07-01 00:00:00
abstract：:Down-regulation of p16INK4a and miR-146b-5p contributes to tumorigenesis in osteosarcoma (OS). However, the correlation between p16INK4a and miR-146b-5p in OS proliferation remains largely unknown. In the present study, we demonstrated that miR-146b-5p expression was positively correlated with p16INK4a in OS, but inve...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20181268
更新日期：2019-02-01 00:00:00
abstract：OBJECTIVE:To study the correlation between adenomatous polyposis coli (APC) gene 3' untranslated region (UTR) single nucleotide polymorphisms (SNPs) and their interactions with environmental factors and the risk of colorectal cancer (CRC) in a Chinese Han population. METHODS:Genotypes of APC gene 3'UTR rs1804197, rs41...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20192429
更新日期：2020-03-27 00:00:00
abstract：:Myocardial ischemia/reperfusion (MI/R) triggers a complicated chain of inflammatory reactions. Dexmedetomidine (Dex) has been reported to be important in myocardial disorders. We evaluated the role of Dex in MI/R injury via the silent information regulator factor 2-related enzyme 1 (SIRT1)/mammalian target of rapamyci...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20194030
更新日期：2020-05-29 00:00:00
abstract：:Although membrane fusion occurs ubiquitously and continuously in all eukaroytic cells, little is known about the mechanism that governs lipid bilayer fusion associated with any intracellular fusion reactions. Recent studies of the fusion of enveloped viruses with host cell membranes have helped to define the fusion pr...
journal_title：Bioscience reports
pub_type： 杂志文章,评审
doi：10.1023/a:1010454803579
更新日期：2000-12-01 00:00:00
abstract：:The Gram-positive bacterium Staphylococcus pseudintermedius is a leading cause of canine bacterial pyoderma, resulting in worldwide morbidity in dogs. S. pseudintermedius also causes life-threatening human infections. Furthermore, methicillin-resistant S. pseudintermedius is emerging, resembling the human health threa...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20140088
更新日期：2014-11-24 00:00:00
abstract：:This review covers the recent progress in the elucidation of the structure of photosystem II (PSII). Because much of the structural information for this membrane protein complex has been revealed by electron microscopy (EM), the review will also consider the specific technical and interpretation problems that arise wi...
journal_title：Bioscience reports
pub_type： 杂志文章,评审
doi：10.1007/BF01206204
更新日期：1996-04-01 00:00:00
abstract：:Cryogenic transmission electron microscopy (cryo-TEM) is a high-resolution biological imaging method, whereby biological samples, such as purified proteins, macromolecular complexes, viral particles, organelles and cells, are embedded in vitreous ice preserving their native structures. Due to sensitivity of biological...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20170203
更新日期：2018-04-27 00:00:00
abstract：:Sulphate efflux from human placental microvillus membrane vesicles was inhibited by external DIDS (KI congruent to 10(-6) M). This inhibition was partially reversed on addition of the translocated substrates sulphate or selenate to the external medium: selenite which is not translocated does not protect against DIDS i...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01116242
更新日期：1986-10-01 00:00:00
abstract：:Disc nucleus pulposus (NP) cell experiences periodic osmolarity alterations during daily activities, which has been proved to affect cell biology in vitro The present study was aimed to investigate the effects of cartilage-derived morphogenetic protein-2 (CDMP-2) on NP cell apoptosis under the hyperosmolarity culture ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20181176
更新日期：2018-10-09 00:00:00
abstract：:miR-155 has multiple functions in many physiological and pathological processes. However, little is known about the expression characteristics of avian miR-155. In the present study, partial pri-miR-155 sequences were cloned from AA+ broiler, Sanhuang broiler and Hy-Line Brown layer, respectively. Stem-loop qRT-PCR wa...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20193796
更新日期：2020-06-26 00:00:00
abstract：:Prognostic significance of family with sequence similarity 83, member D (FAM83D) in hepatocellular carcinoma (HCC) patients has not been well-investigated using Gene Expression Omnibus (GEO) series and TCGA database, we compared FAM83D expression levels between tumor and adjacent tissues, and correlated FAM83D in tumo...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20181640
更新日期：2019-05-07 00:00:00
abstract：:Tuberculosis (TB), a leading infectious disease caused by Mycobacterium tuberculosis strain, takes four human lives every minute globally. Paucity of knowledge on M. tuberculosis virulence and antibiotic resistance is the major challenge for tuberculosis control. We have identified 47 acetyltransferases in the M. tube...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20191661
更新日期：2019-12-20 00:00:00
abstract：:Blood platelets have the capacity to participate in a number of physiological as well as pathological processes within the circulation. In order to evaluate their cellular reactivity a number of platelet function tests have been developed. The main in vitro function tests are assessment of aggregation and adhesion, se...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01114683
更新日期：1989-06-01 00:00:00
abstract：:A key mechanism mediating cellular adaptive responses to hypoxia involves the activity of hypoxia-inducible factor 1 (HIF-1), a transcription factor composed of HIF-1α, and HIF-1β subunits. The classical mechanism of regulation of HIF-1 activity involves destabilisation of HIF-1α via oxygen-dependent hydroxylation of ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20192345
更新日期：2020-01-31 00:00:00
abstract：:Unstable angina pectoris (UA) is one of the most dangerous clinical symptoms of acute coronary syndrome due to the risk of myocardial ischemia, which can lead to high morbidity and mortality worldwide. Though there are many advantages in understanding the pathophysiology of UA, the identification of biomarkers for the...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20181658
更新日期：2019-03-22 00:00:00
abstract：:Folic acid (FA), which is necessary for normal cell division of mammals, has been implicated to be involved in many tumors. Dietary FA intake has been reported to be associated with a lower risk of nasopharyngeal cancer (NPC). However, the molecular mechanisms of FA in NPC cells remain unclear. In the present study, w...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20170772
更新日期：2017-12-05 00:00:00
