Somatostatin binding sites in cytosolic fractions of parietal and non-parietal cells from rabbit fundic mucosa.

Abstract:

:Specific binding sites for somatostatin have been found in the cytosolic fractions of both parietal and non-parietal cells from rabbit gastric fundic mucosa. The stoichiometric data suggested the presence of two classes of binding sites in both types of cells. The number of low-affinity binding sites was significantly higher in parietal cells than in non-parietal cells. The reverse was true for the high-affinity binding sites. However, the affinity of each class of binding sites was similar in the cytosolic fractions of both parietal and non-parietal cells. It thus appears that low-affinity somatostatin binding sites are mainly located in the parietal cells whereas the high-affinity sites occur principally in the non-parietal cells.

journal_name

Biosci Rep

journal_title

Bioscience reports

authors

Arilla E,López-Ruiz MP,Gonzalez-Guijarro L,Prieto JC

doi

10.1007/BF01116904

subject

Has Abstract

pub_date

1985-04-01 00:00:00

pages

321-8

issue

4

eissn

0144-8463

issn

1573-4935

journal_volume

5

pub_type

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