Abstract：
:Circulating human neutrophils exhibited low rates of protein biosynthesis, as determined by their ability to incorporate [35S]methionine into TCA-precipitable material. Exposure of cells to the chemotactic peptide (N-formyl-L-methionyl-L-leucyl-L-phenylalanine) increased their rate of protein synthesis, and the maximal stimulation of biosynthesis by this inflammatory agent was observed at 0.1 microM: this concentration of chemotactic peptide "primed" neutrophil activity and only activated the oxidase of these cells by 8% of maximum. The newly-synthesized proteins were analyzed by two-dimensional polyacrylamide gel electrophoresis and compared with those synthesized in control cells. Two classes of proteins were observed in "primed" cells. The first of these comprised proteins whose rate of biosynthesis changed very little upon "priming" whereas the second class comprised proteins whose rate of synthesis increased greatly after exposure to chemotactic peptide. The fMet-Leu-Phe stimulated protein synthesis was inhibited by actinomycin D and cycloheximide showing that this phenomenon required both transcription and translation. We propose that these fMet-Leu-Phe regulated proteins play an important role in the function of neutrophils during an inflammatory response.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Hughes V,Humphreys JM,Edwards SWdoi
10.1007/BF01119479subject
Has Abstractpub_date
1987-11-01 00:00:00pages
881-90issue
11eissn
0144-8463issn
1573-4935journal_volume
7pub_type
杂志文章abstract：:A possible role for Ca2+ and calmodulin in the action of growth-hormone-releasing factor (GHRF) was investigated. Low extracellular Ca2+ (less than 100 microM), methoxyverapamil, flunarizine, cinnarizine, and Co2+ decreased both basal and GHRF-stimulated growth-hormone secretion, but did not totally inhibit GHRF-stimu...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01116691
更新日期：1984-12-01 00:00:00
abstract：:Objectives In the present study, we examined available articles from online databases to comprehensively investigate the effect of the XPC (xeroderma pigmentosum complementation group C) rs2228000 polymorphism on the risk of different types of clinical cancer. Methods We conducted a group of overall and subgroup pooli...
journal_title：Bioscience reports
pub_type： 杂志文章,meta分析
doi：10.1042/BSR20192452
更新日期：2019-12-20 00:00:00
abstract：:A novel approach was used to assess the role of phosphoinositide hydrolysis in the mitogenic action of phytohemagglutinin (PHA) or concanavalin A (ConA). The treatment of human peripheral blood leukocytes (PBL) with monospecific antibodies against phospholipase C (PLC) produced a dose-dependent inhibition (up to 100%)...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01116866
更新日期：1987-09-01 00:00:00
abstract：:Signal transducer and activator of transcription (STAT), a family of latent cytoplasmic transcription factors, are composed of seven identified members (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). STATs are associated with several biological processes such as cell proliferation, invasion, and metastasis in var...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20170650
更新日期：2017-07-16 00:00:00
abstract：:Gamma- and delta-isomers of hexachlorocyclohexane caused marked decreases in the levels of radioactive phospholipids, and increases in the levels of [3H]arachidonate incorporated into free fatty acids in rat renal tubular cells. The increased radioactivity of free fatty acids arises from the decrease of [3H]arachidona...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01540453
更新日期：1995-08-01 00:00:00
abstract：:Previous studies demonstrated that the adaptive response to stressors and inflammatory signals involves the activation of the autonomous [corrected] nervous system. Catecholamines have been shown to modulate the activity of various immune effector cells directly via membrane adrenergic receptors. Here, we investigated...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1023/a:1014768909442
更新日期：2001-10-01 00:00:00
abstract：:To determine whether up-regulation of miR-1183 targeting the gene for anti-apoptotic factor, B-cell lymphoma 2 (BCL-2) contributes to apoptosis in patients with rheumatic heart disease (RHD). Peripheral blood samples were isolated for miR-1183 characterization. The function of miRNA-1183 in RHD using miRNA mimic on PB...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20201573
更新日期：2020-11-27 00:00:00
abstract：:Inactivation of p53 is one of the most relevant events in human cancer, since it allows transformed cells to escape their own proliferation control and leave them irresponsive to drugs that aim to damage their DNA. When p53 falls, other members of its family may become targets to attack tumoural cells. p73 has shown c...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20150039
更新日期：2015-04-28 00:00:00
abstract：:Endothelin-1 (ET-1) and plasminogen activator inhibitor-1 (PAI-1) play important roles in pulmonary hypertension (PH) in sickle cell disease (SCD). Our previous studies show higher levels of placenta growth factor (PlGF) in SCD correlate with increased plasma levels of ET-1, PAI-1, and other physiological markers of P...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20150190
更新日期：2015-10-12 00:00:00
abstract：:MicroRNAs (miRNAs) have been frequently identified as key mediators in almost all developmental and pathological processes, including those in the liver. The present study was conducted with aims of investigating the role of microRNA-138 (miR-138) in acute liver failure (ALF) via a mechanism involving p53 and liver ma...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20190763
更新日期：2019-07-18 00:00:00
abstract：:NUF2 (NUF2, Ndc80 kinetochore complex component) plays an important role in kinetochore-microtubule attachment. It has been reported that NUF2 is associated with multiple human cancers. However, the functional role of NUF2 in pancreatic cancer remains unclear. In this study, we found that NUF2 expression was stronger ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20140124
更新日期：2015-01-14 00:00:00
abstract：:Wilms tumor is the most common pediatric malignancy in the kidney. The miR34b/c is a downstream target gene of the transcription factor p53. The important role of TP53 mutations, the methylation of miR34b/c, and the interaction between these two molecules in tumorigenesis have been well documented. Due to the biologic...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20194202
更新日期：2020-02-28 00:00:00
abstract：:We have previously established a rat model of chronic uremia, which is suitable to investigate the effect of various treatment modalities on renal osteodystrophy [1]. After four months subsequent to 5/6 nephrectomy, some animals were treated by gavage for 9 weeks with tap water (controls), or with aluminium (Al-citrat...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01201001
更新日期：1996-02-01 00:00:00
abstract：:Long non-coding RNAs (lncRNA) CASC2 is a key player in cancer biology. Our new findings showed that both lncRNA CASC2 and IL-17 were up-regulated in plasma of osteoarthritis patients. Plasma levels of lncRNA CASC2 and IL-17 were significantly and positive correlated only in osteoarthritis patients. Overexpression of l...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20182454
更新日期：2019-05-14 00:00:00
abstract：:Isoliquiritigenin (ISL), a natural product isolated from licorice root, exhibits anti-gastric cancer effects. However, applications of ISL are still limited in clinical practice due to its poor bioavailability. To discovery of more effective anti-gastric cancer agents based on ISL, aldol condensation reaction was appl...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20201199
更新日期：2020-06-26 00:00:00
abstract：:Background: Single-nucleotide polymorphisms (SNPs) in lncRNAs could be biomarkers for susceptibility to colorectal cancer (CRC), but the association of PCAT1 polymorphisms and CRC susceptibility is yet to be studied. Methods: Five tagSNPs covering the PCAT1 gene were detected through Kompetitive Allele-Specific PCR am...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20190708
更新日期：2019-07-12 00:00:00
abstract：:In the course of evolution, mitochondria lost their independence, and mtDNA became "slave" of nDNA, depending on numerous nucleus-encoded factors for its integrity, replication and expression. Mutations in any of these factors may alter the cross-talk between the two genomes and cause diseases that affect mtDNA integr...
journal_title：Bioscience reports
pub_type： 杂志文章,评审
doi：10.1007/s10540-007-9036-1
更新日期：2007-06-01 00:00:00
abstract：:A model explaining quantal Ca2+ release as an intrinsic property of the inositol 1,4,5-triphosphate (IP3) receptor has been put forward. The model is based on the hypothesis that the IP3 receptor can catalyze a transformation of the IP3 molecule differing from its conventional metabolism. A simple kinetic mechanism is...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01207265
更新日期：1996-10-01 00:00:00
abstract：:A non-ionic detergent such as Lubrol-PX extracts in soluble form the VIP-binding structures of rat liver plasma membranes. Detergent-solubilized proteins bind specifically [125I]VIP and the complex tracer-protein is identified by the use of Sepharose 6B columns. The interaction is only possible in the absence of deter...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01145177
更新日期：1986-01-01 00:00:00
abstract：:Superoxide dismutase (SOD), a metal containing enzyme is present in parasite Leishmania donovani as well as in host macrophages both resident and activated in a detectable amount, although the level is much higher in the latter case. It is observed that at any particular protein concentration, the SOD activity is high...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01116457
更新日期：1988-04-01 00:00:00
abstract：:Circulating tumor cells can provide important diagnostic and prognostic information of the patients with non-small cell lung cancer (NSCLC). Aldehyde dehydrogenase 1 (ALDH1), a cancer stem cell marker, has been used in various tumors, including NSCLC. In the present study, we isolated the circulating ALDH1+ tumor cell...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20180914
更新日期：2018-10-31 00:00:00
abstract：:Erythrocytes suspended in a medium of low ionic strength lyse under the effect of an exponential electrical pulse. The percentage of haemolysed cells decreases several-fold in the presence of divalent cations. The protective action of the ions studied increases in the following order: Ca++, Mg++, Zn++. It is assumed t...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01121639
更新日期：1988-10-01 00:00:00
abstract：:The Gram-positive bacterium Staphylococcus pseudintermedius is a leading cause of canine bacterial pyoderma, resulting in worldwide morbidity in dogs. S. pseudintermedius also causes life-threatening human infections. Furthermore, methicillin-resistant S. pseudintermedius is emerging, resembling the human health threa...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20140088
更新日期：2014-11-24 00:00:00
abstract：:The physiological role of an alternative oxidase and an uncoupling protein in plant and protists is discussed in terms of thermogenesis and energy metabolism balance in the cell. It is concluded that thermogenesis is restricted not only by a lower-limit size but also by a kinetically-limited stimulation of the mitocho...
journal_title：Bioscience reports
pub_type： 杂志文章,评审
doi：10.1023/a:1013656510245
更新日期：2001-04-01 00:00:00
abstract：BACKGROUND:Glioblastoma (GBM) is the most common malignant brain tumor with a poor prognosis. The initial treatment for high-grade gliomas is surgical excision. However, even with concomitant use of radiation or chemotherapy, patients are still prone to recurrence. The specific pathogenesis of GBM is still controversia...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20201401
更新日期：2020-06-26 00:00:00
abstract：:Artocarpus incisa (breadfruit) seeds contain three different lectins (Frutalin, Frutapin (FTP) and Frutackin) with distinct carbohydrate specificities. The most abundant lectin is Frutalin, an α-D-galactose-specific carbohydrate-binding glycoprotein with antitumour properties and potential for tumour biomarker discove...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20170969
更新日期：2017-07-21 00:00:00
abstract：:A natural avermectin complex, aversectin C, was shown to be capable of exerting selective cytostatic and neurotoxic effects on mammalian cells. Specifically, it killed proliferating neuroblastoma B103 cells but was non-toxic for differentiated cells of this culture. The antiproliferation action of aversectin C was not...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1023/a:1020262811459
更新日期：1999-12-01 00:00:00
abstract：:The unicellular Tetrahymena enzymatically split the synthetic phosphodiester, 4-methylumbelliferyl phosphocholine substrate. The enzyme activity was completely blocked in vitro and drastically inhibited in vivo by G-protein activating fluorides (NaF; AIF4- and BeF3-). The phospholipase A2 inhibitor, quinacrine, and th...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1023/a:1020154325630
更新日期：1999-04-01 00:00:00
abstract：:Glycine methyl ester, an inhibitor of transglutaminase, decreased glucose-stimulated insulin release and delayed proinsulin conversion in rat pancreatic islets pulse-labelled with L-[4-3H]phenylalanine. Sarcosine methyl ester, which does not inhibit transglutaminase activity, failed to affect insulin release and proin...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01117071
更新日期：1985-07-01 00:00:00
abstract：:Clustered Regularly Interspaced Short Palindromic Repeat activation-synergistic activation mediator system (CRISPRa-SAM) has been efficiently used to up-regulate the targeted genes in human and mouse. But it is not known whether the CRISPRa-SAM system can be used against porcine disease because its two important trans...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20191496
更新日期：2019-08-19 00:00:00
