Effects of microvirin monomers and oligomers on hepatitis C virus.

abstract：:Hepatocellular carcinoma (HCC) has a high recurrence rate and poor clinical outcome after currently used therapies, including radiofrequency ablation. To explore the possible mechanisms for the relapse of HCC, in the present study we focussed on long non-coding RNA (LncRNA), which has been reported to be involved in t...

journal_title：Bioscience reports

authors： Zhu X,Yu H,Li B,Quan J,Zeng Z,Li G,Liu J

更新日期：2019-11-29 00:00:00

abstract：:Previous studies demonstrated that the adaptive response to stressors and inflammatory signals involves the activation of the autonomous [corrected] nervous system. Catecholamines have been shown to modulate the activity of various immune effector cells directly via membrane adrenergic receptors. Here, we investigated...

journal_title：Bioscience reports

authors： Lünemann JD,Buttgereit F,Tripmacher R,Baerwald CG,Burmester GR,Krause A

更新日期：2001-10-01 00:00:00

abstract：:Dendritic cells (DCs) present exogenous antigens on major histocompatibility complex (MHC) class I molecules, thereby activating CD8+ T cells, contributing to tumor elimination through a mechanism known as antigen cross-presentation. A variety of factors such as maturation state of DCs, co-stimulatory signals, T-cell ...

journal_title：Bioscience reports

authors： Warrier VU,Makandar AI,Garg M,Sethi G,Kant R,Pal JK,Yuba E,Gupta RK

更新日期：2019-10-30 00:00:00

abstract：:PDC (pyruvate dehydrogenase complex) is a multi-enzyme complex comprising an E1 (pyruvate decarboxylase), an E2 (dihydrolipomide acetyltransferase) and an E3 (dihydrolipoamide dehydrogenase). PDC catalyses the decarboxylation of pyruvate and forms acetyl-CoA and NADH. In the human malaria parasite Plasmodium falciparu...

journal_title：Bioscience reports

authors： Laine LM,Biddau M,Byron O,Müller S

更新日期：2015-01-14 00:00:00

abstract：:Hippo pathway is a highly conservative signalling pathway related to the development of organisms, which has been demonstrated to be strongly linked to the tumorigenesis and tumour progression. As the major downstream effector of Hippo pathway, yes-associated protein (YAP), is a transcriptional activator of target gen...

journal_title：Bioscience reports

authors： Wang S,Ma K,Chen L,Zhu H,Liang S,Liu M,Xu N

更新日期：2016-09-29 00:00:00

abstract：:Objective: To explore whether aspirin (ASA) enhances the sensitivity of hepatocellular carcinoma (HCC) side population (SP) cells to doxorubicin (Doxo) via miR-491/ATP-binding cassette sub-family G member 2 (ABCG2).Methods: Non-SP and SP cells were isolated from MHCC-97L cell line using flow cytometry analysis and flu...

journal_title：Bioscience reports

authors： Xie ZY,Liu MS,Zhang C,Cai PC,Xiao ZH,Wang FF

更新日期：2018-11-09 00:00:00

abstract：:Endothelin-1 (ET-1) and plasminogen activator inhibitor-1 (PAI-1) play important roles in pulmonary hypertension (PH) in sickle cell disease (SCD). Our previous studies show higher levels of placenta growth factor (PlGF) in SCD correlate with increased plasma levels of ET-1, PAI-1, and other physiological markers of P...

journal_title：Bioscience reports

authors： Gonsalves CS,Li C,Malik P,Tahara SM,Kalra VK

更新日期：2015-10-12 00:00:00

abstract：:The tetracycline repressor (TetR)-regulated system is a widely used tool to study gene functions through control of its expression. Various effectors such as tetracycline (Tc) and doxycycline (Dox) quickly induce or shut down gene expression, but reversing gene expression has not been eligible due to long half-lives o...

journal_title：Bioscience reports

authors： Song C,Kim N,Park M,Lee J,Oh KB,Sim T

更新日期：2019-01-08 00:00:00

abstract：:Osteoarthritis (OA) is one of the most common chronic joint disease. Long non-coding RNAs (lncRNAs) have been confirmed to play important roles in a variety of diseases including OA. However, the underlying mechanism of lncRNA differentiation antagonizing non-protein coding RNA (DANCR) in OA has not been well elucidat...

journal_title：Bioscience reports

authors： Zhang L,Zhang P,Sun X,Zhou L,Zhao J

更新日期：2018-12-14 00:00:00

abstract：:We have investigated a novel method to monitor real changes of intracellular ROS by the use of CMH2TMRos (a reduced form of MitoTracker orange) in Swiss 3T3 fibroblasts. Arachidonic acid induced a rapid increase of CMTMRos fluorescence with a maximal elevation at 120-150 sec, which was determined by scanning every 10 ...

journal_title：Bioscience reports

authors： Kweon SM,Kim HJ,Lee ZW,Kim SJ,Kim SI,Paik SG,Ha KS

更新日期：2001-06-01 00:00:00

abstract：:A natural avermectin complex, aversectin C, was shown to be capable of exerting selective cytostatic and neurotoxic effects on mammalian cells. Specifically, it killed proliferating neuroblastoma B103 cells but was non-toxic for differentiated cells of this culture. The antiproliferation action of aversectin C was not...

journal_title：Bioscience reports

authors： Kokoz YM,Tsyganova VG,Korystova AF,Grichenko AS,Zenchenko KI,Drinyaev VA,Mosin VA,Kruglyak EB,Sterlina TS,Victorov AV

更新日期：1999-12-01 00:00:00

abstract：:Abnormal aggregation of pathological tau protein is a neuropathological feature of Alzheimer's disease (AD). In the AD patients, the abnormal tau accumulation first appeared in entorhinal cortex (EC) and then propagated to the hippocampus with microglia activation and inflammation, but the mechanism is elusive. Here, ...

journal_title：Bioscience reports

authors： Liu Y,Zhang S,Li X,Liu E,Wang X,Zhou Q,Ye J,Wang JZ

更新日期：2020-02-28 00:00:00

abstract：:Thrombospondins (TSPs) are evolutionarily-conserved, secreted glycoproteins that interact with cell surfaces and extracellular matrix (ECM) and have complex roles in cell interactions. Unlike the structural components of the ECM that form networks or fibrils, TSPs are deposited into ECM as arrays of nanoscale puncta. ...

journal_title：Bioscience reports

authors： Hellewell AL,Gong X,Schärich K,Christofidou ED,Adams JC

更新日期：2015-05-20 00:00:00

abstract：:Isolated mouse pancreatic islets were infected in vitro with two strains of Coxsackie B4 virus--a tissue culture-adapted strain and a mouse pancreas-adapted strain. Within 48 h of infection changes had occurred in the biochemical activities of islets infected with the mouse pancreas-adapted strain of virus. Basal insu...

journal_title：Bioscience reports

authors： Szopa TM,Gamble DR,Taylor KW

更新日期：1985-01-01 00:00:00

abstract：:To clarify the mechanism of circGOLPH3 regulation on prostate cancer cells, we performed an overexpression and interference circGOLPH3 assay in prostate cancer cells PC-3 and then evaluated cellular viability, proliferation, cell cycle, and apoptosis of prostate cancer cells by MTT, CCK8, Edu stain, TUNEL stain, and f...

journal_title：Bioscience reports

authors： Gong L,Tang Y,Jiang L,Tang W,Luo S

更新日期：2020-12-23 00:00:00

abstract：:Keratin 18 (KRT18) has been suggested to be overexpressed in most types of human tumor, but the expression pattern of KRT18 in colorectal cancer (CRC) remained unknown. In our research, KRT18 protein expression was markedly increased in CRC cancer tissues and cell lines compared with adjacent normal colorectal tissues...

journal_title：Bioscience reports

authors： Zhang J,Hu S,Li Y

更新日期：2019-08-13 00:00:00

abstract：:Objective: We aimed to assess the possible relations between serum levels of macrophage migration inhibitory factor (MIF), a central cytokine of the innate immunity and inflammatory response, and benign paroxysmal positional vertigo (BPPV) risk and BPPV recurrence events.Methods: In the present study, 154 patients wit...

journal_title：Bioscience reports

authors： Cai HB,Duan L,Tian T,Li ZC,Zhao CC,Ge ZM

更新日期：2019-08-23 00:00:00

abstract：:In order to gain information on the metabolism of dolichol, the rates of excretion of dolichol and dolichyl phosphate were determined in rats maintained on a dolichol-free diet for 10 days. Analysis of fecal samples collected every 48 h yielded mean output values of 9.0 +/- 1.4 and 20.7 +/- 3.0 micrograms/rat/day of d...

journal_title：Bioscience reports

authors： Connelly LW,Keller RK

更新日期：1984-09-01 00:00:00

abstract：:As a zinc transporter, SLC39A7 (zip7) is vital in intestinal epithelial self-renewal, and recent studies suggested that SLC39A7 was related to cancer progression. Whereas, little is known about the role of SLC39A7 in gastric cancer (GC). In the present study, qRT-PCR analysis demonstrated that SLC39A7 mRNA level was i...

journal_title：Bioscience reports

authors： Zhang Y,Bai J,Si W,Yuan S,Li Y,Chen X

更新日期：2020-02-28 00:00:00

abstract：:Rodney Porter's separation of antibody molecules into Fab and Fc fragments engendered the notion that a single antibody polypeptide chain might be coded by two or more genes. This concept profoundly influenced the development of molecular immunology over the past 25 years. Our current knowledge of antibody gene organi...

journal_title：Bioscience reports

authors： Fleischman JB

更新日期：1985-10-01 00:00:00

abstract：:The present study investigated the effects of Isorhamnetin on two types of prostate cancer cells (androgen-independent and androgen-dependent) and explored its possible mechanisms underlying such effects. Treatment with Isorhamnetin significantly inhibited cell growth and induced lactate dehydrogenase (LDH) release of...

journal_title：Bioscience reports

authors： Cai F,Zhang Y,Li J,Huang S,Gao R

更新日期：2020-03-27 00:00:00

abstract：BACKGROUND:Disc degeneration is correlated with mechanical load. Osteogenic protein-1 (OP-1) is potential to regenerate degenerative disc. OBJECTIVE:To investigate whether OP-1 can protect against high magitude compression-induced nucleus pulposus (NP) cell apoptosis and NP matrix catabolism, and its potential mechani...

journal_title：Bioscience reports

authors： Fang H,Li X,Shen H,Sun B,Teng H,Li P

更新日期：2018-02-13 00:00:00

abstract：:We have investigated the intramembranal ion traffic in apoptotic 3T6 cells in culture. Apoptosis was induced by various treatments, such as serum deprivation, high density growth and hydrogen peroxide at subnecrotic doses. Cell death was assessed by nucleosomal DNA fragmentation, single cell electrophoresis, immunoflu...

journal_title：Bioscience reports

authors： Bonincontro A,Iacoangeli A,Melucci-Vigo G,Risuleo G

更新日期：1997-12-01 00:00:00

abstract：:Facioscapulohumeral muscular dystrophy (FSHD) region gene 1 (FRG1) is a candidate gene for FSHD. FRG1 regulates various muscle-related functions, but studies have proposed its role in development and angiogenesis also, where it is involved with tumor-associated molecules. Therefore, we decided to look into its role in...

journal_title：Bioscience reports

authors： Tiwari A,Pattnaik N,Mohanty Jaiswal A,Dixit M

更新日期：2017-10-27 00:00:00

abstract：:A major cause of failure in chemotherapy is drug resistance of cancer cells. Exosomes have been introduced to spread chemoresistance through delivering miRNAs. However, a systematic evaluation of the exosomal miRNA expression profiles responsible for chemoresistance is still lacking. In the present study, miRNA signat...

journal_title：Bioscience reports

authors： Chen WX,Xu LY,Qian Q,He X,Peng WT,Zhu YL,Cheng L

更新日期：2018-11-15 00:00:00

abstract：:Background: The present study aimed to evaluate serum 25-hydroxy vitamin D (25(OH) D) levels in Chinese patients with idiopathic benign paroxysmal positional vertigo (BPPV) and to investigate the possible relationship between the occurrence and recurrence of idiopathic BPPV and low 25(OH) D levels. Methods: Between 1 ...

journal_title：Bioscience reports

authors： Ding J,Liu L,Kong WK,Chen XB,Liu X

更新日期：2019-04-30 00:00:00

abstract：:Breast cancer remains a leading cause of cancer-related mortality in women. In recent years, regulation of genes involved in heparan sulphate (HS) biosynthesis have received increased interest as regulators of breast cancer cell adhesion and invasion. The exostosin (EXT) proteins are glycosyltransferases involved in e...

journal_title：Bioscience reports

authors： Sembajwe LF,Katta K,Grønning M,Kusche-Gullberg M

更新日期：2018-08-31 00:00:00

abstract：:Polycationic amino acids induce the leakage and fusion of liposomes containing anionic lipids. We have investigated the nature and extent of the changes in membrane physical properties caused by these polypeptides which could result in the observed membrane destabilization. We found that in the range of pH 5 to pH 7 b...

journal_title：Bioscience reports

authors： Epand RM,Lim W

更新日期：1995-06-01 00:00:00

abstract：:The present study estimates the effect of rivaroxaban on preventing deep vein thrombosis (DVT) in aged diabetics with femoral neck fractures after hip replacement. Our study consisted of 236 aged diabetics with femoral neck fractures, which were divided into the rivaroxaban and control groups. Reaction time (R time), ...

journal_title：Bioscience reports

authors： Zhang YM,Jiang X,Sun YS

更新日期：2017-06-21 00:00:00

abstract：:Background: Endometrial carcinoma (EC) still threatens the health of women. Thus, to explore how long intergenic non-protein coding RNA 01220 regulates the development of EC.Methods: Whole genome expression profile data of EC and paracancerous tissues in TCGA database were downloaded. LINC01220 expression in EC and pa...

journal_title：Bioscience reports

authors： Li Y,Kong C,Wu C,Wang Y,Xu B,Liang S,Ying X

更新日期：2019-07-25 00:00:00