Eukaryotic-type serine/threonine kinase mediated phosphorylation at Thr169 perturbs mycobacterial guanylate kinase activity.

abstract：:Members of the ADAM (a disintegrin and metalloproteinase) family of proteins possess a multidomain architecture which permits functionalities as adhesion molecules, signalling intermediates and proteolytic enzymes. ADAM8 is found on immune cells and is induced by multiple pro-inflammatory stimuli suggesting a role in ...

journal_title：Bioscience reports

authors： Hall T,Leone JW,Wiese JF,Griggs DW,Pegg LE,Pauley AM,Tomasselli AG,Zack MD

更新日期：2009-08-01 00:00:00

abstract：:In the present study, we aimed to examine whether SET domain-containing methyltransferases are up-regulated in different classes of renal cell carcinoma. We immunoblotted against SET domain and quantified the expression of these modular domains. Furthermore, we examined the expression of Rad51, the key protein that co...

journal_title：Bioscience reports

authors： Liu S,Li Y,Xu H,Wang K,Li N,Li J,Sun T,Xu Y

更新日期：2016-06-30 00:00:00

abstract：:Significant amounts of somatostatin-like immunoreactivity (SLI) were detected in the extract of a human catecholamine-secreting adrenal medullary tumour. After salt fractionation and reconstitution the major portion of SLI was purified by gel filtration and two HPLC steps; in all three systems it eluted in the positio...

journal_title：Bioscience reports

authors： Corder R,Sykes JE,Lowry PJ

更新日期：1982-03-01 00:00:00

abstract：:Conflicting opinions were recently expressed concerning the possible effect of alpha 2-adrenergic agonists upon cyclic AMP production in pancreatic islets. In the present study, clonidine inhibited glucose-induced insulin release from rat pancreatic islets, this inhibitory effect being abolished by idazoxan. Clonidine...

journal_title：Bioscience reports

authors： Garcia-Morales P,Dufrane SP,Sener A,Valverde I,Malaisse WJ

更新日期：1984-06-01 00:00:00

abstract：:Partitioning in charge-sensitive dextran-poly(ethylene glycol) aqueous phase systems reveals that fixation with even small concentrations of glutaraldehyde (e.g., 0.1% w/v) changes the surface properties of cells. While fixation with larger concentrations of glutaraldehyde (i.e., 1.85%) increases erythrocyte partition...

journal_title：Bioscience reports

authors： Walter H,Krob EJ

更新日期：1989-12-01 00:00:00

abstract：:The present study was conducted with the aim being to investigate the effect γ-aminobutyric acid type B (GABAB) receptor activation have on spatial cognitive function and hippocampal neurones found in the rat models of type 2 diabetes mellitus (T2DM). T2DM rat models were then established, randomized, and subsequently...

journal_title：Bioscience reports

authors： Cai XJ,Wang L,Hu CM

更新日期：2018-01-19 00:00:00

abstract：:Wilms tumor is the most common renal malignancy that occurs in children. TP53 gene is considered as a tumor-suppressing gene through controlling cell growth. TP53 gene rs1042522 C>G (Arg72Pro) polymorphism is widely investigated in various types of cancers. However, it is not established if TP53 rs1042522 C>G polymorp...

journal_title：Bioscience reports

authors： Liu P,Zhuo Z,Li W,Cheng J,Zhou H,He J,Zhang J,Wang J

更新日期：2019-01-22 00:00:00

abstract：:To the best of our knowledge, this is the first study established a nomogram to predict survival probability in Asian patients with LSCC. A risk prediction nomogram for patients with LSCC, incorporating easily assessable clinicopathologic factors, generates more precise estimations of the survival probability when com...

journal_title：Bioscience reports

authors： Cui J,Wang L,Zhong W,Chen Z,Tan X,Yang H,Chen J,Liu G

更新日期：2020-08-28 00:00:00

abstract：:Diabetes mellitus (DM) is a potential etiology of disc degeneration. Glucagon-like peptide-1 (GLP-1) is currently regarded as a powerful treatment option for type 2 diabetes. Apart from the beneficial effects on glycaemic control, GLP-1 has been reported to exert functions in a variety of tissues on modulation of cell...

journal_title：Bioscience reports

authors： Ming-Yan Y,Jing Z,Shu-Qin G,Xiao-Liang B,Zhi-Hong L,Xue Z

更新日期：2019-08-19 00:00:00

abstract：:Ca-ATPase activity in sarcoplasmic reticulum (SR) membranes isolated from skeletal muscles of the typical hibernator, the ground squirrel Spermophilus undulatus, is about 2-fold lower than that in SR membranes of rats and rabbits and is further decreased 2-fold during hibernation. The use of carbocyanine anionic dye S...

journal_title：Bioscience reports

authors： Malysheva AN,Storey KB,Lopina OD,Rubtsov AM

更新日期：2001-12-01 00:00:00

abstract：:Ric c1, an allergenic protein from Ricinus communis , is an insect α-amylase inhibitor that has become an occupational allergen. Ric c1 can cross-react with allergens from wheat, soybean, peanut, shrimp, fish, gluten, house dust, tobacco, and air fungus, thereby amplifying the concern and risks caused by Ricinus aller...

journal_title：Bioscience reports

authors： Pacheco-Soares T,de Oliveira Carvalho A,da Silva Araújo J,de Souza GDS,Machado OLT

更新日期：2018-02-14 00:00:00

abstract：:miRNAs have been implicated in processing of cardiac hypoxia/reoxygenation (H/R)-induced injury. Recent studies demonstrated that miR-19a might provide a potential cardioprotective effect on myocardial disease. However, the effect of miR-19a in regulating myocardial ischemic injury has not been previously addressed. T...

journal_title：Bioscience reports

authors： Sun G,Lu Y,Li Y,Mao J,Zhang J,Jin Y,Li Y,Sun Y,Liu L,Li L

更新日期：2017-12-05 00:00:00

abstract：:A key mechanism mediating cellular adaptive responses to hypoxia involves the activity of hypoxia-inducible factor 1 (HIF-1), a transcription factor composed of HIF-1α, and HIF-1β subunits. The classical mechanism of regulation of HIF-1 activity involves destabilisation of HIF-1α via oxygen-dependent hydroxylation of ...

journal_title：Bioscience reports

authors： Kim J,Barsoum IB,Loh H,Paré JF,Siemens DR,Graham CH

更新日期：2020-01-31 00:00:00

abstract：:Canstatin, the non-collagenous domain of collagen type IV α-chains, belongs to a series of collagen-derived angiogenic inhibitors. In this study, the inhibitory effect of recombinant canstatin on tumour growth was investigated using a gastric cancer xenograft model. The volume and weight of tumours in mice treated wit...

journal_title：Bioscience reports

authors： Xing YN,Deng P,Xu HM

更新日期：2014-04-01 00:00:00

abstract：:Merremia vitifolia (Burm.f.) Hallier f., an ethnomedicinally important plant, used in the tribal areas to treat various ailments including fever, headache, eye inflammation, rheumatism, dysentery, jaundice and urinary diseases. The present study explored the biological efficacy of the aqueous fraction of M. vitifolia ...

journal_title：Bioscience reports

authors： Akter S,Jahan I,Khatun MR,Khan MF,Arshad L,Jakaria M,Haque MA

更新日期：2021-01-29 00:00:00

abstract：:Decreasing extracellular sodium concentration was found to produce a contractile response of rabbit ileal smooth muscle. As the concentration decreases, the amplitude of contraction increases, thus producing a dose-dependent curve. Harmaline, a competitor for sodium, was found to inhibit the sodium gradient-dependent ...

journal_title：Bioscience reports

authors： Suleiman MS

更新日期：1985-08-01 00:00:00

abstract：:Cryptococcus neoformans is an opportunistic fungal pathogen that causes life-threatening meningitis primarily in immunocompromised individuals. In order to survive and proliferate during infection, C. neoformans must adapt to a variety of stresses it encounters within the host. Patient outcome depends on the interacti...

journal_title：Bioscience reports

authors： Altamirano S,Jackson KM,Nielsen K

更新日期：2020-10-30 00:00:00

abstract：:Four days of fasting in the rat reduced brown-adipose-tissue (BAT) mass, mitochondrial protein, and tissue protein content. Specific binding of guanosine diposphate (GDP) to BAT mitochondria was depressed by 55% in 4d-fasted rats. Rats fasted for 3 d, and then refed a single carbohydrate meal (40 kJ), showed a signifi...

journal_title：Bioscience reports

authors： Rothwell NJ,Saville ME,Stock MJ

更新日期：1984-04-01 00:00:00

abstract：:Erectile dysfunction (ED) is one of the significant complications of diabetes mellitus (DM), and CASR plays an important role in cellular antiapoptosis and NO production in the vascular endothelium by activating PKC. The present study was aimed to investigate the efficacy of Leech and Centipede Granules (LCG) through ...

journal_title：Bioscience reports

authors： Ma JX,Wang B,Ding CF,Li HS,Jiang XJ,Wang CY,Yu J,Chen WQ

更新日期：2020-02-28 00:00:00

abstract：:TRα1 (thyroid hormone receptor α1) is well recognized for its importance in brain development. However, due to the difficulties in predicting TREs (thyroid hormone response elements) in silico and the lack of suitable antibodies against TRα1 for ChIP (chromatin immunoprecipitation), only a few direct TRα1 target genes...

journal_title：Bioscience reports

authors： Dudazy-Gralla S,Nordström K,Hofmann PJ,Meseh DA,Schomburg L,Vennström B,Mittag J

更新日期：2013-03-13 00:00:00

abstract：:Folic acid (FA), which is necessary for normal cell division of mammals, has been implicated to be involved in many tumors. Dietary FA intake has been reported to be associated with a lower risk of nasopharyngeal cancer (NPC). However, the molecular mechanisms of FA in NPC cells remain unclear. In the present study, w...

journal_title：Bioscience reports

authors： Liu Z,Jin X,Pi W,Liu S

更新日期：2017-12-05 00:00:00

abstract：:The inhibition of passive K+ influx into human red blood cells (RBC) by loop diuretics was found to be dependent on the external Na+ concentration. In the absence of external Na+, there was minimal inhibition but the influx remained dependent on Cl- ions. Thus, raising the external Na+ concentration increased the affi...

journal_title：Bioscience reports

authors： Chipperfield AR

更新日期：1985-04-01 00:00:00

abstract：OBJECTIVE:The current study aimed to investigate the functional roles and clinical significance of microRNA-148a (miR-148a) in the progression of oral squamous cell carcinoma (OSCC). METHODS:Relative expression of miR-148a in OSCC cells and tissues were detected using quantitative real-time polymerase chain reaction (...

journal_title：Bioscience reports

authors： Jia T,Ren Y,Wang F,Zhao R,Qiao B,Xing L,Ou L,Guo B

更新日期：2020-04-30 00:00:00

abstract：:Keratin 18 (KRT18) has been suggested to be overexpressed in most types of human tumor, but the expression pattern of KRT18 in colorectal cancer (CRC) remained unknown. In our research, KRT18 protein expression was markedly increased in CRC cancer tissues and cell lines compared with adjacent normal colorectal tissues...

journal_title：Bioscience reports

authors： Zhang J,Hu S,Li Y

更新日期：2019-08-13 00:00:00

abstract：:Retinitis pigmentosa (RP) is a group of hereditary, degenerative retinal disorders characterized by progressive retinal dysfunction, outer retina cell loss, and retinal tissue atrophy. It eventually leads to tunnel vision and legal, or total blindness. Here we aimed to reveal the causal gene and mutation contributing ...

journal_title：Bioscience reports

authors： Huang X,Yuan L,Xu H,Zheng W,Cao Y,Yi J,Guo Y,Yang Z,Li Y,Deng H

更新日期：2018-04-27 00:00:00

abstract：:Ovarian cancer is a highly lethal cancer in females. Therefore, it is necessary to explore effective biomarkers for the diagnosis and prognosis of the disease. Stratifin (SFN) is a cell cycle checkpoint protein that has been reported to be involved in oncogenesis. Our studies detected the expression of SFN in ovarian ...

journal_title：Bioscience reports

authors： Hu Y,Zeng Q,Li C,Xie Y

更新日期：2019-05-02 00:00:00

abstract：:A novel approach was used to assess the role of phosphoinositide hydrolysis in the mitogenic action of phytohemagglutinin (PHA) or concanavalin A (ConA). The treatment of human peripheral blood leukocytes (PBL) with monospecific antibodies against phospholipase C (PLC) produced a dose-dependent inhibition (up to 100%)...

journal_title：Bioscience reports

authors： Moraru II,Manciulea M,Călugăru A,Ghyka G,Popescu LM

更新日期：1987-09-01 00:00:00

abstract：:NUF2 (NUF2, Ndc80 kinetochore complex component) plays an important role in kinetochore-microtubule attachment. It has been reported that NUF2 is associated with multiple human cancers. However, the functional role of NUF2 in pancreatic cancer remains unclear. In this study, we found that NUF2 expression was stronger ...

journal_title：Bioscience reports

authors： Hu P,Chen X,Sun J,Bie P,Zhang LD

更新日期：2015-01-14 00:00:00

abstract：:The proton conductance of the mitochondrial inner membrane can be quantified by applying Ohm's law to the experimentally determined protonmotive force and the proton current flowing around the proton circuit in the absence of ATP synthesis or ion transport. This last parameter is derived from the rate of State 4 respi...

journal_title：Bioscience reports

authors： Nicholls DG

更新日期：1997-06-01 00:00:00

abstract：:The secretory process is a coordinated cellular response, initiated by occupation of surface receptors and comprising an ordered sequence of biochemical steps subject to multiple controls. Conceptually we can divide the sequence into two main sections comprising early, receptor-mediated events leading to generation of...

journal_title：Bioscience reports

authors： Gomperts BD,Cockcroft S,Howell TW,Nüsse O,Tatham PE

更新日期：1987-05-01 00:00:00