Orf virus: A promising new therapeutic agent.

abstract：:It is well known that viruses, as obligate intracellular parasites, must use their hosts' metabolic machinery in order to replicate their genomes and form infectious progeny virions. What is less well known are the details of how viruses make sure that once all the necessary proteins are made, that they assume the cor...

journal_title：Reviews in medical virology

authors： Byrd CM,Hruby DE

更新日期：2006-05-01 00:00:00

abstract：:Haemophagocytic syndrome (HPS) or haemophagocytic lymphohistiocytosis (HLH) is a rare disease caused by a dysfunction of cytotoxic T cells and NK cells. This T cell/NK cell dysregulation causes an aberrant cytokine release, resulting in proliferation/activation of histiocytes with subsequent haemophagocytosis. Histioc...

journal_title：Reviews in medical virology

authors： Maakaroun NR,Moanna A,Jacob JT,Albrecht H

更新日期：2010-03-01 00:00:00

abstract：:The serine/threonine kinase expressed by human cytomegalovirus from gene UL97 phosphorylates the antiviral drug ganciclovir, but its biological function is the phosphorylation of its natural viral and cellular protein substrates which affect viral replication at many levels. The UL97 kinase null phenotype is therefore...

journal_title：Reviews in medical virology

authors： Prichard MN

更新日期：2009-07-01 00:00:00

abstract：:Dengue disease encompasses various clinical manifestations including dengue fever (DF) and dengue hemorrhagic fever (DHF). In this article, we aimed to systematically review and analyze the association between different blood groups and severity of dengue. We searched nine databases for eligible papers reporting preva...

journal_title：Reviews in medical virology

authors： Hashan MR,Ghozy S,El-Qushayri AE,Pial RH,Hossain MA,Al Kibria GM

更新日期：2021-01-01 00:00:00

abstract：:The viruses able to affect the eye are taxonomically diverse, ranging from double-stranded DNA viruses, to single stranded RNA viruses, to retroviruses. Any part of the eye may be affected, frequently producing blepharitis, conjunctivitis, keratitis, uveitis, cataract and retinitis. The more common ocular viral infect...

journal_title：Reviews in medical virology

authors： Newman H,Gooding C

更新日期：2013-09-01 00:00:00

abstract：:After the serendipitous discovery of HIV eradication in the "Berlin patient", interest has grown in curing HIV infection by replacing the patient's replication-competent blood cells with infection-resistant ones. At the same time, induced pluripotent stem cell technologies and genetic engineering have boosted cell the...

journal_title：Reviews in medical virology

authors： Focosi D,Maggi F,Ceccherini-Nelli L,Pistello M

更新日期：2015-05-01 00:00:00

abstract：:There is a growing appreciation that the regulation of the melatonergic pathways, both pineal and systemic, may be an important aspect in how viruses drive the cellular changes that underpin their control of cellular function. We review the melatonergic pathway role in viral infections, emphasizing influenza and covid...

journal_title：Reviews in medical virology

authors： Anderson G,Reiter RJ

更新日期：2020-05-01 00:00:00

abstract：:Although epidemiological and molecular epidemiological (serotype, genotype, and lineage information) data are available for several major cities in Indonesia, there is yet to be a comprehensive national study of dengue in Indonesia over time. This study was conducted to provide a comprehensive epidemiology of circulat...

journal_title：Reviews in medical virology

authors： Harapan H,Michie A,Yohan B,Shu PY,Mudatsir M,Sasmono RT,Imrie A

更新日期：2019-07-01 00:00:00

abstract：:Hepatitis E virus (HEV) is a positive-stranded RNA virus with a 7.2 kb genome that is capped and polyadenylated. The virus is currently unclassified: the organisation of the genome resembles that of the Caliciviridae but sequence analyses suggest it is more closely related to the Togaviridae. Hepatitis E virus is an e...

journal_title：Reviews in medical virology

authors： Emerson SU,Purcell RH

更新日期：2003-05-01 00:00:00

abstract：:Although the CNS is in part protected from peripheral insults by the blood-brain barrier and the blood-cerebrospinal fluid barrier, a number of human viruses gain access to the brain, replicate within this organ, or sustain latent infection. The efficacy of antiviral drugs towards the cerebral viral load is often limi...

journal_title：Reviews in medical virology

authors： Strazielle N,Ghersi-Egea JF

更新日期：2005-03-01 00:00:00

abstract：:There is a wealth of data supporting the use of viral load measurements to monitor therapy. Indeed, clinical drug trial endpoints routinely include the proportion of patients with a plasma viral load reduction of greater than 0.5 log(10), or greater than 1 log(10). Since a higher viral load reflects increased amounts ...

journal_title：Reviews in medical virology

authors： Pillay D

更新日期：2002-11-01 00:00:00

abstract：:Viral replication and spreading are fundamental events in the viral life cycle, accounting for the assembly and egression of nascent virions, events that are directly associated with viral pathogenesis in target hosts. These processes occur in cellular compartments that are modified by specialized viral proteins, caus...

journal_title：Reviews in medical virology

authors： de Armas-Rillo L,Valera MS,Marrero-Hernández S,Valenzuela-Fernández A

更新日期：2016-05-01 00:00:00

abstract：:Enteroviruses and humans have long co-existed. Although recognized in ancient times, poliomyelitis and type 1 diabetes (T1D) were exceptionally rare and not epidemic, due in large part to poor sanitation and personal hygiene which resulted in repeated exposure to fecal-oral transmitted viruses and other infectious age...

journal_title：Reviews in medical virology

authors： Drescher KM,von Herrath M,Tracy S

更新日期：2015-01-01 00:00:00

abstract：:Vaccination is the current strategy for control and prevention of severe rotavirus infections, a major cause of acute, dehydrating diarrhoea in young children worldwide. Public health interventions aimed at improving water, food and sanitation are unlikely adequately to control the disease. The development of vaccines...

journal_title：Reviews in medical virology

authors： Fischer TK,Gentsch JR

更新日期：2004-03-01 00:00:00

abstract：:While outbreaks of foodborne disease remain an important public health concern, their aetiology is not identified in a majority of instances. In targeted studies, the application of newly developed molecular assays has demonstrated that a large proportion of these outbreaks may be caused by the "Norwalk-like viruses" ...

journal_title：Reviews in medical virology

authors： Parashar UD,Monroe SS

更新日期：2001-07-01 00:00:00

abstract：:The influenza A virus genome consists of eight segmented, single-stranded, negative-sense RNAs. Each viral RNA (vRNA) segment forms a ribonucleoprotein (RNP) complex together with NPs and a polymerase complex, which is a fundamental unit for transcription and replication of the viral genome. Although the exact structu...

journal_title：Reviews in medical virology

authors： Noda T,Kawaoka Y

更新日期：2010-11-01 00:00:00

abstract：:The SCID-hu Thy/Liv mouse is a model for the analysis of human thymopoiesis. It has been constructed by engrafting fragments of human fetal liver and thymus into the immunodeficient C.B-17 scid/scid (SCID) mouse. The resulting 'Thy/Liv' organ promotes long-term differentiation of human T cells. Given the apparently no...

journal_title：Reviews in medical virology

authors： Su L

更新日期：1997-09-01 00:00:00

abstract：:Novel therapeutic options are urgently needed to improve the global treatment of viral infections. Tripartite motif (TRIM) family proteins are involved in various biological and cellular functions including differentiation, development, proliferation, oncogenesis, innate immunity, and viral autophagy. Various TRIM pro...

journal_title：Reviews in medical virology

authors： Khan R,Khan A,Ali A,Idrees M

更新日期：2019-03-01 00:00:00

abstract：:Respiratory infections, especially those of the lower respiratory tract, remain a foremost cause of mortality and morbidity of children greater than 5 years in developing countries including Pakistan. Ignoring these acute-level infections may lead to complications. Particularly in Pakistan, respiratory infections acco...

journal_title：Reviews in medical virology

authors： Naz R,Gul A,Javed U,Urooj A,Amin S,Fatima Z

更新日期：2019-03-01 00:00:00

abstract：:BK polyomavirus (BKPyV or BKV) is a non-enveloped, circular double-stranded DNA virus that may exceed 80% seroprevalence in adults. BKV infection typically occurs during childhood, and the majority of adults are latently infected. While BKV infection is rarely associated with clinical disease in most individuals, in i...

journal_title：Reviews in medical virology

authors： Blackard JT,Davies SM,Laskin BL

更新日期：2020-07-01 00:00:00

abstract：:Herpes simplex virus type-1 (HSV-1) is among the most common human pathogens worldwide. Its entry into host cells is an intricate process that relies heavily on the ability of the viral glycoproteins to bind host cellular proteins and to efficiently mediate fusion of the virus envelope with the cell membrane. Acquisit...

journal_title：Reviews in medical virology

authors： Antoine TE,Park PJ,Shukla D

更新日期：2013-05-01 00:00:00

abstract：:The common mucosal immune system (CMIS) consists of an integrated cross-communication pathway of lymphoid tissues made up of inductive and effector sites for host protection against pathogenic microorganisms. Major effector molecules of the CMIS include IgA antibodies and cytokines, chemokines and their corresponding ...

journal_title：Reviews in medical virology

authors： Iijima H,Takahashi I,Kiyono H

更新日期：2001-03-01 00:00:00

abstract：:The discovery of acyclovir (ACV), a nucleoside analogue, more than 30 years ago, represents a milestone in the management of HSV and VZV infections. The modest activity of ACV against CMV prompted the development of another nucleoside analogue, ganciclovir, for the management of systemic and organ-specific CMV disease...

journal_title：Reviews in medical virology

authors： Piret J,Boivin G

更新日期：2014-05-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) infection is the most common cause of bronchiolitis and pneumonia in the pediatric population worldwide. The immunopathology of RSV infection varies considerably and severe disease occurs only in a minority of the population. There are many factors (host, viral, and environmental) tha...

journal_title：Reviews in medical virology

authors： Tahamtan A,Askari FS,Bont L,Salimi V

更新日期：2019-03-01 00:00:00

abstract：:HIV-1 and HIV-2 share many similarities including their basic gene arrangement, modes of transmission, intracellular replication pathways and clinical consequences: both result in AIDS. However, HIV-2 is characterised by lower transmissibility and reduced likelihood of progression to AIDS. The underlying mechanistic d...

journal_title：Reviews in medical virology

authors： Nyamweya S,Hegedus A,Jaye A,Rowland-Jones S,Flanagan KL,Macallan DC

更新日期：2013-07-01 00:00:00

abstract：:Hepatitis E virus (HEV) is the leading cause of acute viral hepatitis worldwide and an emerging cause of chronic infection in immunocompromised patients. As with viral infections in general, immune responses are critical to determine the outcome of HEV infection. Accumulating studies in cell culture, animal models and...

journal_title：Reviews in medical virology

authors： Hakim MS,Ikram A,Zhou J,Wang W,Peppelenbosch MP,Pan Q

更新日期：2018-03-01 00:00:00

abstract：:Viruses are obligate parasites dependent on host cells for survival. Viral infection of a cell activates a panel of pattern recognition receptors that mediate antiviral host responses to inhibit viral replication and dissemination. Viruses have evolved mechanisms to evade and subvert this antiviral host response, incl...

journal_title：Reviews in medical virology

authors： van Zuylen WJ,Rawlinson WD,Ford CE

更新日期：2016-09-01 00:00:00

abstract：:Amongst the 60 viral species reported to be associated with bats, 59 are RNA viruses, which are potentially important in the generation of emerging and re-emerging infections in humans. The prime examples of these are the lyssaviruses and Henipavirus. The transmission of Nipah, Hendra and perhaps SARS coronavirus and ...

journal_title：Reviews in medical virology

authors： Wong S,Lau S,Woo P,Yuen KY

更新日期：2007-03-01 00:00:00

abstract：:The alarming rise of morbidity and mortality caused by influenza pandemics and epidemics has drawn attention worldwide since the last few decades. This life-threatening problem necessitates the development of a safe and effective vaccine to protect against incoming pandemics. The currently available flu vaccines rely ...

journal_title：Reviews in medical virology

authors： Keshavarz M,Mirzaei H,Salemi M,Momeni F,Mousavi MJ,Sadeghalvad M,Arjeini Y,Solaymani-Mohammadi F,Sadri Nahand J,Namdari H,Mokhtari-Azad T,Rezaei F

更新日期：2019-01-01 00:00:00

abstract：:Viral binding and entry into host cells for various viruses have been studied extensively, yielding a detailed understanding of the overall viral entry process. As cell entry is an essential and requisite process by which a virus initiates infection, it is an attractive target for therapeutic intervention. The advanta...

journal_title：Reviews in medical virology

authors： Kumar PKR

更新日期：2017-11-01 00:00:00