Abstract:
:Novel therapeutic options are urgently needed to improve the global treatment of viral infections. Tripartite motif (TRIM) family proteins are involved in various biological and cellular functions including differentiation, development, proliferation, oncogenesis, innate immunity, and viral autophagy. Various TRIM proteins show antiviral properties against different viral infections and are now transitioning from ubiquitin proteins to an efficient and emerging therapeutic class of proteins. TRIM proteins combat viruses by targeting them at pre/post transcription levels. This review summarizes the comprehensive roles of different TRIM proteins along with their expression systems and their applications towards antiviral therapeutics.
journal_name
Rev Med Viroljournal_title
Reviews in medical virologyauthors
Khan R,Khan A,Ali A,Idrees Mdoi
10.1002/rmv.2028subject
Has Abstractpub_date
2019-03-01 00:00:00pages
e2028issue
2eissn
1052-9276issn
1099-1654journal_volume
29pub_type
杂志文章,评审abstract::Dengue disease encompasses various clinical manifestations including dengue fever (DF) and dengue hemorrhagic fever (DHF). In this article, we aimed to systematically review and analyze the association between different blood groups and severity of dengue. We searched nine databases for eligible papers reporting preva...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.2147
更新日期:2021-01-01 00:00:00
abstract::The serine/threonine kinase expressed by human cytomegalovirus from gene UL97 phosphorylates the antiviral drug ganciclovir, but its biological function is the phosphorylation of its natural viral and cellular protein substrates which affect viral replication at many levels. The UL97 kinase null phenotype is therefore...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.615
更新日期:2009-07-01 00:00:00
abstract::Amongst the 60 viral species reported to be associated with bats, 59 are RNA viruses, which are potentially important in the generation of emerging and re-emerging infections in humans. The prime examples of these are the lyssaviruses and Henipavirus. The transmission of Nipah, Hendra and perhaps SARS coronavirus and ...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.520
更新日期:2007-03-01 00:00:00
abstract::Of all the nutrients, vitamin A has been the most extensively evaluated for its impact on immunity. There are three main forms of vitamin A, retinol, retinal and retinoic acid (RA) with the latter being most biologically active and all-trans-RA (ATRA) its main derivative. Vitamin A is a key regulator of the functions ...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.2204
更新日期:2020-12-31 00:00:00
abstract::The orf virus (ORFV) is a zoonotic, epitheliotropic, DNA parapoxvirus that infects principally sheep and goats. Exposure of animals to the virus or immunization by an ORFV preparation can accentuate the severity of disease, which has provoked an interest in the underlying cellular, virological, and molecular mechanism...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.2013
更新日期:2019-01-01 00:00:00
abstract::The collection of nasopharyngeal swabs to test for the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an invasive technique with implications for patients and clinicians. Alternative clinical specimens from the upper respiratory tract may offer benefits in terms of collection, comfort and ...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.2185
更新日期:2020-10-22 00:00:00
abstract::Infections with the beta-herpesviruses human herpesvirus-6 (HHV-6) and human herpesvirus-7 (HHV-7) are ubiquitous in childhood. The immunosuppression secondary to organ or bone marrow transplantation together with posttransplantation management may favour viral replication and reactivation. HHV-6 and -7 induce immunos...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.299
更新日期:2001-01-01 00:00:00
abstract::The common mucosal immune system (CMIS) consists of an integrated cross-communication pathway of lymphoid tissues made up of inductive and effector sites for host protection against pathogenic microorganisms. Major effector molecules of the CMIS include IgA antibodies and cytokines, chemokines and their corresponding ...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.307
更新日期:2001-03-01 00:00:00
abstract::The recent isolation of West Nile virus from a bird in mid-winter in New York immediately raised, as one of a few explanations, the possibility of long-term persistence of arboviruses in vertebrate hosts. Although it was a highly popular topic for research many years ago, generally it has since been neglected and its ...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.314
更新日期:2001-05-01 00:00:00
abstract::Adjuvants historically are considered to stimulate immune responses 'non-specifically'. Recently, a renewed understanding of the critical role of innate immunity in influencing the development of an adaptive immune response has led researchers to a better understanding of 'the adjuvant effect'. Although innate immune ...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.445
更新日期:2005-01-01 00:00:00
abstract::Hepatitis E virus (HEV) is the leading cause of acute viral hepatitis worldwide and an emerging cause of chronic infection in immunocompromised patients. As with viral infections in general, immune responses are critical to determine the outcome of HEV infection. Accumulating studies in cell culture, animal models and...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.1964
更新日期:2018-03-01 00:00:00
abstract::The alarming rise of morbidity and mortality caused by influenza pandemics and epidemics has drawn attention worldwide since the last few decades. This life-threatening problem necessitates the development of a safe and effective vaccine to protect against incoming pandemics. The currently available flu vaccines rely ...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.2014
更新日期:2019-01-01 00:00:00
abstract::TT virus (TTV) was found in 1997 from a hepatitis patient without virus markers. However, the real impact of TTV on liver diseases remains uncertain to date. Due to the lack of suitable cell systems to support the growth of TTV, the biology of TTV is still obscure. This review tries to summarise the current status of ...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.351
更新日期:2002-05-01 00:00:00
abstract:AUTHOR CONTRIBUTION:FN performed the literature review and wrote the manuscript; STZ coauthored, edited, and reviewed the manuscript. ABSTRACT:Treatment response in Hepatitis C virus (HCV) has generated varied effects in patients. Recently, nonresponsive and relapse patients related to host and genotype variabilities ...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.2120
更新日期:2020-07-01 00:00:00
abstract::The advent of advanced cell culture and cytogenetics techniques in the 1950s opened a new avenue for research on the pathogenic interactions between animal viruses and their hosts. Studies of many viruses revealed their ability to nonspecifically induce cytogenetic damage to their host cell's chromosomes. However, onl...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.368
更新日期:2003-01-01 00:00:00
abstract::Hepatitis E virus (HEV) is a positive-stranded RNA virus with a 7.2 kb genome that is capped and polyadenylated. The virus is currently unclassified: the organisation of the genome resembles that of the Caliciviridae but sequence analyses suggest it is more closely related to the Togaviridae. Hepatitis E virus is an e...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.384
更新日期:2003-05-01 00:00:00
abstract::Viruses are efficient carriers of genetic material between cells. They specifically recognise a target cell and utilise host functions for genome delivery to the replication site. A mature viral capsid emerging from an infected cell serves at least three distinct functions. It enables virus egress from the infected ce...
journal_title:Reviews in medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1099-1654(1998100)8:4<213::aid-rmv22
更新日期:1998-10-01 00:00:00
abstract::While outbreaks of foodborne disease remain an important public health concern, their aetiology is not identified in a majority of instances. In targeted studies, the application of newly developed molecular assays has demonstrated that a large proportion of these outbreaks may be caused by the "Norwalk-like viruses" ...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.321
更新日期:2001-07-01 00:00:00
abstract::Haemophagocytic syndrome (HPS) or haemophagocytic lymphohistiocytosis (HLH) is a rare disease caused by a dysfunction of cytotoxic T cells and NK cells. This T cell/NK cell dysregulation causes an aberrant cytokine release, resulting in proliferation/activation of histiocytes with subsequent haemophagocytosis. Histioc...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.638
更新日期:2010-03-01 00:00:00
abstract::Respiratory syncytial virus (RSV) infection is the most common cause of bronchiolitis and pneumonia in the pediatric population worldwide. The immunopathology of RSV infection varies considerably and severe disease occurs only in a minority of the population. There are many factors (host, viral, and environmental) tha...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.2026
更新日期:2019-03-01 00:00:00
abstract::In the same way as other viral functions, the transcription of viral genes is frequently controlled by cellular regulatory proteins either acting alone or together with virally encoded factors. In this review, I discuss three examples of such regulation in different types of DNA viruses by different members of the POU...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/(sici)1099-1654(199901/03)9:1<31::aid-rmv2
更新日期:1999-01-01 00:00:00
abstract::The novel coronavirus disease-2019 (Covid-19) public health emergency has caused enormous loss around the world. This pandemic is a concrete example of the existing gap between availability of advanced diagnostics and current need for cost-effective methodology. The advent of the loop-mediated isothermal amplification...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.2215
更新日期:2021-01-21 00:00:00
abstract::The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel human respiratory viral infection that has rapidly progressed into a pandemic, causing significant morbidity and mortality. Blood clotting disorders and acute respiratory failure have surfaced as the major complications among the severe cases ...
journal_title:Reviews in medical virology
pub_type: 杂志文章
doi:10.1002/rmv.2177
更新日期:2020-10-06 00:00:00
abstract::Drugs based on amino acid sequence of Heptad Repeats of gp41 of HIV have been explored in search of anti-HIV drugs acting by inhibition of the gp41 6-helix formation and subsequent cellular infection. These are classified under a distinct discipline called HIV fusion inhibitors. Resistance to HIV fusion inhibitors and...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.631
更新日期:2010-01-01 00:00:00
abstract::The mosquito-borne flavivirus, Japanese encephalitis virus (JEV), is the leading cause of virus-induced encephalitis globally and a major public health concern of several countries in Southeast Asia, with the potential to become a global pathogen. The virus is neurotropic, and the disease ranges from mild fever to sev...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.1868
更新日期:2016-03-01 00:00:00
abstract::Invasion of infectious agents through mucosal surfaces can be prevented by use of the common mucosal immune system (CMIS), which interconnects inductive tissues, including Peyer's patches (PPs) and nasopharyngeal-associated lymphoreticular tissue (NALT), and effector tissues of the intestinal and respiratory tracts. I...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.398
更新日期:2003-09-01 00:00:00
abstract::The conventional diagnosis of dengue virus infections includes the detection of the virus in serum or tissue samples, both by isolation in culture or through detection of specific viral molecules (genome RNA or dengue antigens) and detection of specific anti-dengue antibodies (serology). Isolation of dengue virus prov...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.461
更新日期:2005-09-01 00:00:00
abstract::After the serendipitous discovery of HIV eradication in the "Berlin patient", interest has grown in curing HIV infection by replacing the patient's replication-competent blood cells with infection-resistant ones. At the same time, induced pluripotent stem cell technologies and genetic engineering have boosted cell the...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.1831
更新日期:2015-05-01 00:00:00
abstract::Human immunodeficiency virus type 1 (HIV-1), the virus that causes AIDS (acquired immunodeficiency syndrome), is a major global public health issue. Although the advent of combined antiretroviral therapy (ART) has made significant progress in inhibiting HIV replication in patients, HIV-infected cells remain the princi...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.2139
更新日期:2020-11-01 00:00:00
abstract::Type B coxsackieviruses (CV-B) frequently infect the central nervous system (CNS) causing neurological diseases notably meningitis and encephalitis. These infections occur principally among newborns and children. Epidemiological studies of patients with nervous system disorders demonstrate the presence of infectious v...
journal_title:Reviews in medical virology
pub_type: 杂志文章
doi:10.1002/rmv.2191
更新日期:2020-11-07 00:00:00