Abstract:
:BK polyomavirus (BKPyV or BKV) is a non-enveloped, circular double-stranded DNA virus that may exceed 80% seroprevalence in adults. BKV infection typically occurs during childhood, and the majority of adults are latently infected. While BKV infection is rarely associated with clinical disease in most individuals, in immunosuppressed individuals, reactivation may cause kidney (BK-associated nephropathy) or bladder (hemorrhagic cystitis and ureteral stenosis) injury. No antiviral therapies have been approved for the treatment of BKV infection. Reducing immunosuppression is the most effective therapy, although this is not feasible in many patients. Thus, a robust understanding of viral pathogenesis and viral diversity remains important for the development of future therapeutic strategies. Studies of BKV diversity are quite sparse compared to other common viral infections; thus, much of our understanding of BVK variability and evolution relies heavily analogous studies of other viruses such as HIV or viral hepatitis. We provide a comprehensive review of BKV diversity at the population and individual level with careful consideration of how viral variability may impact viral replication, pathogenesis, tropism, and protein function. We also discuss a number of outstanding questions related to BK virus diversity that should be explored rigorously in future studies.
journal_name
Rev Med Viroljournal_title
Reviews in medical virologyauthors
Blackard JT,Davies SM,Laskin BLdoi
10.1002/rmv.2102subject
Has Abstractpub_date
2020-07-01 00:00:00pages
e2102issue
4eissn
1052-9276issn
1099-1654journal_volume
30pub_type
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.1772
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pub_type: 杂志文章,评审
doi:10.1002/rmv.336
更新日期:2001-11-01 00:00:00
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章,评审
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journal_title:Reviews in medical virology
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2021-01-21 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2017-11-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.1868
更新日期:2016-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1999-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2003-05-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1002/rmv.2028
更新日期:2019-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2006-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2003-09-01 00:00:00
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更新日期:2017-05-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2016-09-01 00:00:00
abstract:AUTHOR CONTRIBUTION:FN performed the literature review and wrote the manuscript; STZ coauthored, edited, and reviewed the manuscript. ABSTRACT:Treatment response in Hepatitis C virus (HCV) has generated varied effects in patients. Recently, nonresponsive and relapse patients related to host and genotype variabilities ...
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更新日期:2020-07-01 00:00:00
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更新日期:2010-03-01 00:00:00
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更新日期:2005-01-01 00:00:00
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更新日期:2010-01-01 00:00:00