Abstract:
:It is well known that viruses, as obligate intracellular parasites, must use their hosts' metabolic machinery in order to replicate their genomes and form infectious progeny virions. What is less well known are the details of how viruses make sure that once all the necessary proteins are made, that they assume the correct configuration at the proper time in order to catalyse the efficient assembly of infectious virions. One of the methods employed by viruses to regulate this process is the proteolytic cleavage of viral proteins. Over the past several decades, studies in numerous laboratories have demonstrated that morphogenic proteolysis plays a major and essential role during the assembly and maturation of infectious poxvirus virions. In this review we describe the history of vaccinia virus proteolysis as a prototypic viral system.
journal_name
Rev Med Viroljournal_title
Reviews in medical virologyauthors
Byrd CM,Hruby DEdoi
10.1002/rmv.499subject
Has Abstractpub_date
2006-05-01 00:00:00pages
187-202issue
3eissn
1052-9276issn
1099-1654journal_volume
16pub_type
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journal_title:Reviews in medical virology
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journal_title:Reviews in medical virology
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2016-09-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2006-01-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2004-03-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2020-10-31 00:00:00
abstract::The alarming rise of morbidity and mortality caused by influenza pandemics and epidemics has drawn attention worldwide since the last few decades. This life-threatening problem necessitates the development of a safe and effective vaccine to protect against incoming pandemics. The currently available flu vaccines rely ...
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.478
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abstract::The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel human respiratory viral infection that has rapidly progressed into a pandemic, causing significant morbidity and mortality. Blood clotting disorders and acute respiratory failure have surfaced as the major complications among the severe cases ...
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pub_type: 杂志文章
doi:10.1002/rmv.2177
更新日期:2020-10-06 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.2215
更新日期:2021-01-21 00:00:00
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journal_title:Reviews in medical virology
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journal_title:Reviews in medical virology
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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abstract::HIV-1 and HIV-2 share many similarities including their basic gene arrangement, modes of transmission, intracellular replication pathways and clinical consequences: both result in AIDS. However, HIV-2 is characterised by lower transmissibility and reduced likelihood of progression to AIDS. The underlying mechanistic d...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2013-07-01 00:00:00
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journal_title:Reviews in medical virology
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更新日期:2002-11-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Reviews in medical virology
pub_type: 杂志文章
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更新日期:2019-03-01 00:00:00
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pub_type: 杂志文章,评审
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