Abstract:
:Tat (transactivator of transcription) regulates transcription from the HIV provirus. It plays a crucial role in disease progression, supporting efficient replication of the viral genome. Tat also modulates many functions in the host genome via its interaction with chromatin and proteins. Many of the functions of Tat are associated with its basic domain rich in arginine and lysine residues. It is still unknown why the basic domain exhibits so many diverse functions. However, the highly charged basic domain, coupled with the overall structural flexibility of Tat protein itself, makes the basic domain a key player in binding to or associating with cellular and viral components. In addition, the basic domain undergoes diverse posttranslational modifications, which further expand and modulate its functions. Here, we review the current knowledge of Tat basic domain and its versatile role in the interaction between the virus and the host cell.
journal_name
Rev Med Viroljournal_title
Reviews in medical virologyauthors
Kurnaeva MA,Sheval EV,Musinova YR,Vassetzky YSdoi
10.1002/rmv.2031subject
Has Abstractpub_date
2019-03-01 00:00:00pages
e2031issue
2eissn
1052-9276issn
1099-1654journal_volume
29pub_type
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pub_type: 杂志文章,评审
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doi:10.1002/rmv.2014
更新日期:2019-01-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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更新日期:2016-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2006-01-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章
doi:10.1002/rmv.2037
更新日期:2019-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-09-01 00:00:00
abstract:AUTHOR CONTRIBUTION:FN performed the literature review and wrote the manuscript; STZ coauthored, edited, and reviewed the manuscript. ABSTRACT:Treatment response in Hepatitis C virus (HCV) has generated varied effects in patients. Recently, nonresponsive and relapse patients related to host and genotype variabilities ...
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