Abstract:
:Chikungunya fever (CHIKF) caused by the mosquito-transmitted chikungunya virus (CHIKV) swept into international prominence from late 2005 as an epidemic of CHIKF spread around countries surrounding the Indian Ocean. Although significant advances have been made in understanding the pathobiology of CHIKF, numerous questions still remain. In the absence of commercially available specific drugs to treat the disease, or a vaccine to prevent the diseases, the questions have particular significance. A number of studies have used global proteome analysis to increase our understanding of the process of CHIKV infection using a number of different experimental techniques and experimental systems. In all, over 700 proteins have been identified in nine different analyses by five different groups as being differentially regulated. Remarkably, only a single protein, eukaryotic elongation factor 2, has been identified by more than two different groups as being differentially regulated during CHIKV infection. This review provides a critical overview of the studies that have used global protein profiling to understand CHIKV infection and shows that while a broad consensus is emerging on which biological processes are altered during CHIKV infection, this consensus is poorly supported in terms of consistent identification of any key proteins mediating those biological processes.
journal_name
Rev Med Viroljournal_title
Reviews in medical virologyauthors
Smith DRdoi
10.1002/rmv.1802subject
Has Abstractpub_date
2015-01-01 00:00:00pages
3-18issue
1eissn
1052-9276issn
1099-1654journal_volume
25pub_type
杂志文章,评审abstract::Three non-nucleoside reverse transcriptase inhibitors (NNRTIs) are currently available for treatment of HIV-1 as part of combination antiretroviral therapy. Oral dosing is administered three times daily for delavirdine (DLV), twice daily for nevirapine (NVP), and once daily for efavirenz (EFV). Rash is a common side e...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2000-07-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1002/rmv.2185
更新日期:2020-10-22 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2013-05-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2006-05-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2001-05-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,meta分析
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更新日期:2019-01-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2016-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-03-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2003-05-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2002-11-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.666
更新日期:2010-11-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2017-05-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.2013
更新日期:2019-01-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.2215
更新日期:2021-01-21 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.2102
更新日期:2020-07-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.2028
更新日期:2019-03-01 00:00:00
abstract::The common mucosal immune system (CMIS) consists of an integrated cross-communication pathway of lymphoid tissues made up of inductive and effector sites for host protection against pathogenic microorganisms. Major effector molecules of the CMIS include IgA antibodies and cytokines, chemokines and their corresponding ...
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pub_type: 杂志文章,评审
doi:10.1002/rmv.307
更新日期:2001-03-01 00:00:00
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更新日期:2009-07-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.454
更新日期:2005-03-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.411
更新日期:2004-03-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2019-07-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2009-07-01 00:00:00
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更新日期:2019-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-09-01 00:00:00
abstract:AUTHOR CONTRIBUTION:FN performed the literature review and wrote the manuscript; STZ coauthored, edited, and reviewed the manuscript. ABSTRACT:Treatment response in Hepatitis C virus (HCV) has generated varied effects in patients. Recently, nonresponsive and relapse patients related to host and genotype variabilities ...
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pub_type: 杂志文章,评审
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更新日期:2020-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2010-11-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00