Abstract:
:The influenza A virus genome consists of eight segmented, single-stranded, negative-sense RNAs. Each viral RNA (vRNA) segment forms a ribonucleoprotein (RNP) complex together with NPs and a polymerase complex, which is a fundamental unit for transcription and replication of the viral genome. Although the exact structure of the intact RNP remains poorly understood, recent electron microscopic studies have revealed certain structural characteristics of the RNP. This review focuses on the findings of these various electron microscopic analyses of RNPs extracted from virions and RNPs inside virions. Based on the morphological and structural observations, we present the architecture of RNPs within a virion and discuss the genome packaging mechanism by which the vRNA segments are incorporated into virions.
journal_name
Rev Med Viroljournal_title
Reviews in medical virologyauthors
Noda T,Kawaoka Ydoi
10.1002/rmv.666subject
Has Abstractpub_date
2010-11-01 00:00:00pages
380-91issue
6eissn
1052-9276issn
1099-1654journal_volume
20pub_type
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