Abstract:
:In the same way as other viral functions, the transcription of viral genes is frequently controlled by cellular regulatory proteins either acting alone or together with virally encoded factors. In this review, I discuss three examples of such regulation in different types of DNA viruses by different members of the POU family of transcription factors, all of which involve viruses which play a role in the aetiology of specific human diseases. These are the glial cell-specific transcription of JC virus which is controlled by the glial cell specific POU factor Tst-1; the regulation of human papillomavirus gene expression in the cervix by positively and negatively acting POU factors and the manner in which the balance between lytic or latent infection with HSV is controlled by positively and negatively acting POU factors which differ in their ability to interact with the virally encoded transactivator VP16. As well as being of interest in themselves, these processes may offer a therapeutic target for controlling the diseases caused by these very different viruses.
journal_name
Rev Med Viroljournal_title
Reviews in medical virologyauthors
Latchman DSdoi
10.1002/(sici)1099-1654(199901/03)9:1<31::aid-rmv2keywords:
subject
Has Abstractpub_date
1999-01-01 00:00:00pages
31-8issue
1eissn
1052-9276issn
1099-1654pii
10.1002/(SICI)1099-1654(199901/03)9:1<31::AID-RMV2journal_volume
9pub_type
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