HIV fusion inhibitors.

abstract：:Type B coxsackieviruses (CV-B) frequently infect the central nervous system (CNS) causing neurological diseases notably meningitis and encephalitis. These infections occur principally among newborns and children. Epidemiological studies of patients with nervous system disorders demonstrate the presence of infectious v...

journal_title：Reviews in medical virology

authors： Jmii H,Fisson S,Aouni M,Jaidane H

更新日期：2020-11-07 00:00:00

abstract：:Hepatitis B virus (HBV) is one of the causative agents of hepatocellular carcinoma. The molecular mechanisms of tumorigenesis are complex. One of the host factors involved is apparently the long-lasting inflammatory reaction which accompanies chronic HBV infection. Although HBV lacks a typical viral oncogene, the HBx ...

journal_title：Reviews in medical virology

authors： Niller HH,Ay E,Banati F,Demcsák A,Takacs M,Minarovits J

更新日期：2016-01-01 00:00:00

abstract：:A series of antiviral compounds were examined for their activity against human herpesvirus type 6 (HHV-6), type 7 (HHV-7) and type 8 (HHV-8). They were selected either because they are already approved for clinical use in the treatment of herpesvirus infections (acyclovir, valaciclovir, penciclovir, famciclovir, ganci...

journal_title：Reviews in medical virology

authors： De Clercq E,Naesens L,De Bolle L,Schols D,Zhang Y,Neyts J

更新日期：2001-11-01 00:00:00

abstract：:BK polyomavirus (BKPyV or BKV) is a non-enveloped, circular double-stranded DNA virus that may exceed 80% seroprevalence in adults. BKV infection typically occurs during childhood, and the majority of adults are latently infected. While BKV infection is rarely associated with clinical disease in most individuals, in i...

journal_title：Reviews in medical virology

authors： Blackard JT,Davies SM,Laskin BL

更新日期：2020-07-01 00:00:00

abstract：:Failure of antiretroviral therapy to eradicate HIV, even in individuals who suppress the virus to undetectable levels, is a consequence of persistent infection in latently infected cells and within anatomical reservoirs. Support for the notion that the lungs are distinct anatomical reservoirs of HIV comes from a spect...

journal_title：Reviews in medical virology

authors： Costiniuk CT,Jenabian MA

更新日期：2014-01-01 00:00:00

abstract：:The novel coronavirus disease-2019 (Covid-19) public health emergency has caused enormous loss around the world. This pandemic is a concrete example of the existing gap between availability of advanced diagnostics and current need for cost-effective methodology. The advent of the loop-mediated isothermal amplification...

journal_title：Reviews in medical virology

authors： Chaouch M

更新日期：2021-01-21 00:00:00

abstract：:The viruses able to affect the eye are taxonomically diverse, ranging from double-stranded DNA viruses, to single stranded RNA viruses, to retroviruses. Any part of the eye may be affected, frequently producing blepharitis, conjunctivitis, keratitis, uveitis, cataract and retinitis. The more common ocular viral infect...

journal_title：Reviews in medical virology

authors： Newman H,Gooding C

更新日期：2013-09-01 00:00:00

abstract：:The discovery of acyclovir (ACV), a nucleoside analogue, more than 30 years ago, represents a milestone in the management of HSV and VZV infections. The modest activity of ACV against CMV prompted the development of another nucleoside analogue, ganciclovir, for the management of systemic and organ-specific CMV disease...

journal_title：Reviews in medical virology

authors： Piret J,Boivin G

更新日期：2014-05-01 00:00:00

abstract：:Remdesivir is an antiviral agent that has shown broad-spectrum activity, including against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Clinical trials investigating the role of remdesivir in coronavirus disease 2019 (Covid-19) reported conflicting results. This study aimed to systematically review th...

journal_title：Reviews in medical virology

authors： Elsawah HK,Elsokary MA,Abdallah MS,ElShafie AH

更新日期：2020-10-31 00:00:00

abstract：:Although the CNS is in part protected from peripheral insults by the blood-brain barrier and the blood-cerebrospinal fluid barrier, a number of human viruses gain access to the brain, replicate within this organ, or sustain latent infection. The efficacy of antiviral drugs towards the cerebral viral load is often limi...

journal_title：Reviews in medical virology

authors： Strazielle N,Ghersi-Egea JF

更新日期：2005-03-01 00:00:00

abstract：:Arenaviruses, such as Lassa fever, establish chronic infections in rodents, leading to incidental transmission to humans. Lassa fever is a clinically severe disease, yet the absence of second attacks implies life-long immunity. The aim of this review is to consider whether such immunity could be provided by vaccines. ...

journal_title：Reviews in medical virology

authors： Fisher-Hoch SP,McCormick JB

更新日期：2001-09-01 00:00:00

abstract：:After the serendipitous discovery of HIV eradication in the "Berlin patient", interest has grown in curing HIV infection by replacing the patient's replication-competent blood cells with infection-resistant ones. At the same time, induced pluripotent stem cell technologies and genetic engineering have boosted cell the...

journal_title：Reviews in medical virology

authors： Focosi D,Maggi F,Ceccherini-Nelli L,Pistello M

更新日期：2015-05-01 00:00:00

abstract：:Viruses are obligate parasites dependent on host cells for survival. Viral infection of a cell activates a panel of pattern recognition receptors that mediate antiviral host responses to inhibit viral replication and dissemination. Viruses have evolved mechanisms to evade and subvert this antiviral host response, incl...

journal_title：Reviews in medical virology

authors： van Zuylen WJ,Rawlinson WD,Ford CE

更新日期：2016-09-01 00:00:00

abstract：:The conventional diagnosis of dengue virus infections includes the detection of the virus in serum or tissue samples, both by isolation in culture or through detection of specific viral molecules (genome RNA or dengue antigens) and detection of specific anti-dengue antibodies (serology). Isolation of dengue virus prov...

journal_title：Reviews in medical virology

authors： Teles FR,Prazeres DM,Lima-Filho JL

更新日期：2005-09-01 00:00:00

abstract：:Vaccination is the current strategy for control and prevention of severe rotavirus infections, a major cause of acute, dehydrating diarrhoea in young children worldwide. Public health interventions aimed at improving water, food and sanitation are unlikely adequately to control the disease. The development of vaccines...

journal_title：Reviews in medical virology

authors： Fischer TK,Gentsch JR

更新日期：2004-03-01 00:00:00

abstract：:Herpes simplex virus (HSV) genomic DNA contains at least 74 distinct genes. A set of 40 genes, termed the 'core genes', is commonly found in all herpesviruses; their products include four capsid proteins, six DNA replication proteins, seven DNA packaging/cleavage proteins, four envelope glycoproteins, as well as sever...

journal_title：Reviews in medical virology

authors： Nishiyama Y

更新日期：2004-01-01 00:00:00

abstract：:Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) are two γ-herpesviruses identified in humans and are strongly associated with the development of malignancies. Murine γ-herpesvirus (MHV-68) is a naturally occurring rodent pathogen, representing a unique experimental model for dissecting γ-he...

journal_title：Reviews in medical virology

authors： Hu Z,Usherwood EJ

更新日期：2014-11-01 00:00:00

abstract：:Human herpesvirus 7, reported in 1990 is a lymphotropic member of the betaherpesvirus subfamily of herpesviruses. The virus is highly seroprevalent, primary infection usually occurs during childhood, and it has been associated with cases of exanthem subitum, pityriasis rosea, neurological manifestations and transplant...

journal_title：Reviews in medical virology

authors： Black JB,Pellett PE

更新日期：1999-10-01 00:00:00

abstract：:There is a wealth of data supporting the use of viral load measurements to monitor therapy. Indeed, clinical drug trial endpoints routinely include the proportion of patients with a plasma viral load reduction of greater than 0.5 log(10), or greater than 1 log(10). Since a higher viral load reflects increased amounts ...

journal_title：Reviews in medical virology

authors： Pillay D

更新日期：2002-11-01 00:00:00

abstract：:Hepatitis E virus (HEV) is the leading cause of acute viral hepatitis worldwide and an emerging cause of chronic infection in immunocompromised patients. As with viral infections in general, immune responses are critical to determine the outcome of HEV infection. Accumulating studies in cell culture, animal models and...

journal_title：Reviews in medical virology

authors： Hakim MS,Ikram A,Zhou J,Wang W,Peppelenbosch MP,Pan Q

更新日期：2018-03-01 00:00:00

abstract：:Amongst the 60 viral species reported to be associated with bats, 59 are RNA viruses, which are potentially important in the generation of emerging and re-emerging infections in humans. The prime examples of these are the lyssaviruses and Henipavirus. The transmission of Nipah, Hendra and perhaps SARS coronavirus and ...

journal_title：Reviews in medical virology

authors： Wong S,Lau S,Woo P,Yuen KY

更新日期：2007-03-01 00:00:00

abstract：:The alarming rise of morbidity and mortality caused by influenza pandemics and epidemics has drawn attention worldwide since the last few decades. This life-threatening problem necessitates the development of a safe and effective vaccine to protect against incoming pandemics. The currently available flu vaccines rely ...

journal_title：Reviews in medical virology

authors： Keshavarz M,Mirzaei H,Salemi M,Momeni F,Mousavi MJ,Sadeghalvad M,Arjeini Y,Solaymani-Mohammadi F,Sadri Nahand J,Namdari H,Mokhtari-Azad T,Rezaei F

更新日期：2019-01-01 00:00:00

abstract：:The success of vaccination against measles in developed countries has significantly reduced the incidence of measles-related morbidity and mortality. However, measles is still the leading cause of mortality in children from underdeveloped countries due to low vaccination coverage, high transmissibility of the measles ...

journal_title：Reviews in medical virology

authors： Dhiman N,Jacobson RM,Poland GA

更新日期：2004-07-01 00:00:00

abstract：:The immense difficulty in primary control of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infection by adaptive immune responses has been a topic of exceptional importance. CD8+ cytotoxic T lymphocytes (CTLs) do play a central role in primary resolution of viremia, but their potency in vi...

journal_title：Reviews in medical virology

authors： Yamamoto H,Matano T

更新日期：2008-09-01 00:00:00

abstract：:It is well known that viruses, as obligate intracellular parasites, must use their hosts' metabolic machinery in order to replicate their genomes and form infectious progeny virions. What is less well known are the details of how viruses make sure that once all the necessary proteins are made, that they assume the cor...

journal_title：Reviews in medical virology

authors： Byrd CM,Hruby DE

更新日期：2006-05-01 00:00:00

abstract：:Respiratory infections, especially those of the lower respiratory tract, remain a foremost cause of mortality and morbidity of children greater than 5 years in developing countries including Pakistan. Ignoring these acute-level infections may lead to complications. Particularly in Pakistan, respiratory infections acco...

journal_title：Reviews in medical virology

authors： Naz R,Gul A,Javed U,Urooj A,Amin S,Fatima Z

更新日期：2019-03-01 00:00:00

abstract：:The serine/threonine kinase expressed by human cytomegalovirus from gene UL97 phosphorylates the antiviral drug ganciclovir, but its biological function is the phosphorylation of its natural viral and cellular protein substrates which affect viral replication at many levels. The UL97 kinase null phenotype is therefore...

journal_title：Reviews in medical virology

authors： Prichard MN

更新日期：2009-07-01 00:00:00

abstract：:Hepatitis E virus (HEV) is responsible for more than 50% of acute viral hepatitis cases in endemic countries. Approximately 2 billion individuals live in hepatitis E-endemic areas and, therefore, are at risk of infection. According to World Health Organization, HEV causes about 20.1 million infections and 70 000 death...

journal_title：Reviews in medical virology

authors： Pérez-Gracia MT,Suay-García B,Mateos-Lindemann ML

更新日期：2017-05-01 00:00:00

abstract：:Tat (transactivator of transcription) regulates transcription from the HIV provirus. It plays a crucial role in disease progression, supporting efficient replication of the viral genome. Tat also modulates many functions in the host genome via its interaction with chromatin and proteins. Many of the functions of Tat a...

journal_title：Reviews in medical virology

authors： Kurnaeva MA,Sheval EV,Musinova YR,Vassetzky YS

更新日期：2019-03-01 00:00:00

abstract：:The advent of advanced cell culture and cytogenetics techniques in the 1950s opened a new avenue for research on the pathogenic interactions between animal viruses and their hosts. Studies of many viruses revealed their ability to nonspecifically induce cytogenetic damage to their host cell's chromosomes. However, onl...

journal_title：Reviews in medical virology

authors： Fortunato EA,Spector DH

更新日期：2003-01-01 00:00:00