Abstract:
:The success of vaccination against measles in developed countries has significantly reduced the incidence of measles-related morbidity and mortality. However, measles is still the leading cause of mortality in children from underdeveloped countries due to low vaccination coverage, high transmissibility of the measles virus as well as primary and secondary vaccine failure. As with any viral disease, the identification of the host molecule to which the measles virus binds and gains entry into the host cell is a major step in understanding the molecular pathology of the disease. Two cell surface receptors, CD46 and signaling lymphocyte-activation molecule (SLAM), have been identified as measles virus receptors. CD46 is ubiquitously expressed on all nucleated cells and acts as a receptor for the Edmonston strain and all vaccine strains derived from it. SLAM is selectively expressed on some T and B cells and is utilised by the Edmonston strain and wild-type strains that cannot use CD46 for cell entry. Understanding the structural and functional variations in measles virus receptors with regard to host response can facilitate the development of new vaccines as well as provide new insights into measles virus tropism and pathogenesis and, importantly, into possible mechanisms for vaccine non-response. Our review focuses on the structure of measles virus receptors, measles virus receptor function, isoforms and polymorphic forms.
journal_name
Rev Med Viroljournal_title
Reviews in medical virologyauthors
Dhiman N,Jacobson RM,Poland GAdoi
10.1002/rmv.430keywords:
subject
Has Abstractpub_date
2004-07-01 00:00:00pages
217-29issue
4eissn
1052-9276issn
1099-1654journal_volume
14pub_type
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journal_title:Reviews in medical virology
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journal_title:Reviews in medical virology
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更新日期:2016-01-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.1802
更新日期:2015-01-01 00:00:00
abstract::The common mucosal immune system (CMIS) consists of an integrated cross-communication pathway of lymphoid tissues made up of inductive and effector sites for host protection against pathogenic microorganisms. Major effector molecules of the CMIS include IgA antibodies and cytokines, chemokines and their corresponding ...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.307
更新日期:2001-03-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.1872
更新日期:2016-05-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.615
更新日期:2009-07-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.1929
更新日期:2017-05-01 00:00:00
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journal_title:Reviews in medical virology
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doi:10.1002/rmv.2013
更新日期:2019-01-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1099-1654(199709)7:3<157::aid-rmv197
更新日期:1997-09-01 00:00:00
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journal_title:Reviews in medical virology
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2001-09-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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journal_title:Reviews in medical virology
pub_type: 杂志文章
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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journal_title:Reviews in medical virology
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,meta分析
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更新日期:2019-01-01 00:00:00