Abstract:
:Bacteriophages or phages, being the most abundant entities on earth, represent a potential solution to a diverse range of problems. Phages are successful antibacterial agents whose use in therapeutics was hindered by the discovery of antibiotics. Eventually, because of the development and spread of antibiotic resistance among most bacterial species, interest in phage as therapeutic entities has returned, because their noninfectious nature to humans should make them safe for human nanomedicine. This review highlights the most recent advances and progress in phage therapy and bacterial hosts against which phage research is currently being conducted with respect to food, human, and marine pathogens. Bacterial immunity against phages and tactics of phage revenge to defeat bacterial defense systems are also summarized. We have also discussed approved phage-based products (whole phage-based products and phage proteins) and shed light on their influence on the eukaryotic host with respect to host safety and induction of immune response against phage preparations. Moreover, creation of phages with desirable qualities and their uses in cancer treatment, vaccine production, and other therapies are also reviewed to bring together evidence from the scientific literature about the potentials and possible utility of phage and phage encoded proteins in the field of therapeutics and industrial biotechnology.
journal_name
Rev Med Viroljournal_title
Reviews in medical virologyauthors
Rehman S,Ali Z,Khan M,Bostan N,Naseem Sdoi
10.1002/rmv.2041subject
Has Abstractpub_date
2019-07-01 00:00:00pages
e2041issue
4eissn
1052-9276issn
1099-1654journal_volume
29pub_type
杂志文章,评审abstract::While outbreaks of foodborne disease remain an important public health concern, their aetiology is not identified in a majority of instances. In targeted studies, the application of newly developed molecular assays has demonstrated that a large proportion of these outbreaks may be caused by the "Norwalk-like viruses" ...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.321
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journal_title:Reviews in medical virology
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pub_type: 杂志文章,评审
doi:10.1002/rmv.2185
更新日期:2020-10-22 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.307
更新日期:2001-03-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.409
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journal_title:Reviews in medical virology
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更新日期:2009-07-01 00:00:00
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journal_title:Reviews in medical virology
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更新日期:2019-03-01 00:00:00
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更新日期:2019-01-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2001-09-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1099-1654(1998100)8:4<213::aid-rmv22
更新日期:1998-10-01 00:00:00
abstract::Herpes simplex virus type-1 (HSV-1) is among the most common human pathogens worldwide. Its entry into host cells is an intricate process that relies heavily on the ability of the viral glycoproteins to bind host cellular proteins and to efficiently mediate fusion of the virus envelope with the cell membrane. Acquisit...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.1740
更新日期:2013-05-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.2147
更新日期:2021-01-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.478
更新日期:2005-11-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.638
更新日期:2010-03-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.499
更新日期:2006-05-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.2028
更新日期:2019-03-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2014-05-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2001-01-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2016-09-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2013-09-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/(sici)1099-1654(199910/12)9:4<245::aid-rmv
更新日期:1999-10-01 00:00:00
abstract::The alarming rise of morbidity and mortality caused by influenza pandemics and epidemics has drawn attention worldwide since the last few decades. This life-threatening problem necessitates the development of a safe and effective vaccine to protect against incoming pandemics. The currently available flu vaccines rely ...
journal_title:Reviews in medical virology
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doi:10.1002/rmv.2014
更新日期:2019-01-01 00:00:00
abstract::The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel human respiratory viral infection that has rapidly progressed into a pandemic, causing significant morbidity and mortality. Blood clotting disorders and acute respiratory failure have surfaced as the major complications among the severe cases ...
journal_title:Reviews in medical virology
pub_type: 杂志文章
doi:10.1002/rmv.2177
更新日期:2020-10-06 00:00:00
abstract::Hepatitis E virus (HEV) is a positive-stranded RNA virus with a 7.2 kb genome that is capped and polyadenylated. The virus is currently unclassified: the organisation of the genome resembles that of the Caliciviridae but sequence analyses suggest it is more closely related to the Togaviridae. Hepatitis E virus is an e...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.384
更新日期:2003-05-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2002-05-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2021-01-21 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.2187
更新日期:2020-10-31 00:00:00
abstract::Hepatitis B virus (HBV) is one of the causative agents of hepatocellular carcinoma. The molecular mechanisms of tumorigenesis are complex. One of the host factors involved is apparently the long-lasting inflammatory reaction which accompanies chronic HBV infection. Although HBV lacks a typical viral oncogene, the HBx ...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.1864
更新日期:2016-01-01 00:00:00