Abstract:
:After the serendipitous discovery of HIV eradication in the "Berlin patient", interest has grown in curing HIV infection by replacing the patient's replication-competent blood cells with infection-resistant ones. At the same time, induced pluripotent stem cell technologies and genetic engineering have boosted cell therapy transfer into the clinic. Currently available cell therapy approaches to attempt to cure HIV infection include the following: (1) Transplantation of autologous or allogeneic cells spontaneously resistant or edited to resist HIV infection; (2) Transplantation of autologous T-lymphocytes spontaneously targeting or redirected against HIV; and (3) Transplantation of autologous cells engineered to work as anti-HIV antibody factories. We review here the preliminary results and potential for future applications of these approaches.
journal_name
Rev Med Viroljournal_title
Reviews in medical virologyauthors
Focosi D,Maggi F,Ceccherini-Nelli L,Pistello Mdoi
10.1002/rmv.1831subject
Has Abstractpub_date
2015-05-01 00:00:00pages
156-74issue
3eissn
1052-9276issn
1099-1654journal_volume
25pub_type
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