Abstract:
:Although the CNS is in part protected from peripheral insults by the blood-brain barrier and the blood-cerebrospinal fluid barrier, a number of human viruses gain access to the brain, replicate within this organ, or sustain latent infection. The efficacy of antiviral drugs towards the cerebral viral load is often limited as both blood-brain interfaces impede their cerebral distribution. For polar compounds, the major factor restricting their entry lies in the tight junctions that occlude the paracellular pathway across these barriers. For compounds with more favourable lipid solubility properties, CNS penetration will be function of a number of physicochemical factors that include the degree of lipophilicity, size and ability to bind to protein or red blood cells, as well as other factors inherent to the vascular and choroidal systems, such as the local cerebral blood flow and the surface area available for exchange. In addition, influx and efflux transport systems, or metabolic processes active in both capillary endothelial cells and choroid plexus epithelial cells, can greatly change the bioavailability of a drug in one or several compartments of the CNS. The relative importance of these various factors with respect to the CNS delivery of the different classes of antiviral drugs is illustrated and discussed.
journal_name
Rev Med Viroljournal_title
Reviews in medical virologyauthors
Strazielle N,Ghersi-Egea JFdoi
10.1002/rmv.454keywords:
subject
Has Abstractpub_date
2005-03-01 00:00:00pages
105-33issue
2eissn
1052-9276issn
1099-1654journal_volume
15pub_type
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journal_title:Reviews in medical virology
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2003-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-03-01 00:00:00
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更新日期:2015-01-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2018-03-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2010-11-01 00:00:00
abstract::The mosquito-borne flavivirus, Japanese encephalitis virus (JEV), is the leading cause of virus-induced encephalitis globally and a major public health concern of several countries in Southeast Asia, with the potential to become a global pathogen. The virus is neurotropic, and the disease ranges from mild fever to sev...
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更新日期:2016-03-01 00:00:00
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更新日期:2013-07-01 00:00:00
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journal_title:Reviews in medical virology
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更新日期:2010-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Reviews in medical virology
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abstract::The novel coronavirus disease-2019 (Covid-19) public health emergency has caused enormous loss around the world. This pandemic is a concrete example of the existing gap between availability of advanced diagnostics and current need for cost-effective methodology. The advent of the loop-mediated isothermal amplification...
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更新日期:2005-09-01 00:00:00
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更新日期:2001-07-01 00:00:00
abstract:AUTHOR CONTRIBUTION:FN performed the literature review and wrote the manuscript; STZ coauthored, edited, and reviewed the manuscript. ABSTRACT:Treatment response in Hepatitis C virus (HCV) has generated varied effects in patients. Recently, nonresponsive and relapse patients related to host and genotype variabilities ...
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pub_type: 杂志文章,评审
doi:10.1002/rmv.2120
更新日期:2020-07-01 00:00:00