Abstract:
:Infections with the beta-herpesviruses human herpesvirus-6 (HHV-6) and human herpesvirus-7 (HHV-7) are ubiquitous in childhood. The immunosuppression secondary to organ or bone marrow transplantation together with posttransplantation management may favour viral replication and reactivation. HHV-6 and -7 induce immunosuppression by targeting lymphocytes, natural killer cells and monocytes. HHV-6 is commonly detected posttransplantation but variability in definitions of clinical syndromes related to this virus and detection methods have complicated understanding of the clinical relevance of HHV-6 posttransplantation. Clinical symptoms associated with HHV-6 include febrile illness, pneumonitis, hepatitis, encephalitis and bone marrow suppression. However, the majority of HHV-6 infections are asymptomatic. The incidence of HHV-7 infection and its clinical manifestations posttransplantation are even less well characterised. In addition, HHV-6 and HHV-7 are related to CMV disease or acute graft-versus-host disease and, indirectly, to increases in resource utilisation. Based on the potential relevance of these two beta-herpesviruses in transplant recipients, further studies are required to establish their real impact in transplantation. For this, sensitive and specific molecular diagnostic techniques allowing for the rapid detection and quantitation of virus and for the analysis of susceptibility to current antiviral agents are required.
journal_name
Rev Med Viroljournal_title
Reviews in medical virologyauthors
Dockrell DH,Paya CVdoi
10.1002/rmv.299keywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
23-36issue
1eissn
1052-9276issn
1099-1654pii
10.1002/rmv.299journal_volume
11pub_type
杂志文章,评审abstract::Three non-nucleoside reverse transcriptase inhibitors (NNRTIs) are currently available for treatment of HIV-1 as part of combination antiretroviral therapy. Oral dosing is administered three times daily for delavirdine (DLV), twice daily for nevirapine (NVP), and once daily for efavirenz (EFV). Rash is a common side e...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/1099-1654(200007/08)10:4<217::aid-rmv279>3
更新日期:2000-07-01 00:00:00
abstract::The success of vaccination against measles in developed countries has significantly reduced the incidence of measles-related morbidity and mortality. However, measles is still the leading cause of mortality in children from underdeveloped countries due to low vaccination coverage, high transmissibility of the measles ...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2004-07-01 00:00:00
abstract::The immense difficulty in primary control of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infection by adaptive immune responses has been a topic of exceptional importance. CD8+ cytotoxic T lymphocytes (CTLs) do play a central role in primary resolution of viremia, but their potency in vi...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2008-09-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.615
更新日期:2009-07-01 00:00:00
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更新日期:2021-01-21 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2020-10-22 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.1791
更新日期:2014-11-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章
doi:10.1002/rmv.2177
更新日期:2020-10-06 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.1747
更新日期:2013-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2020-10-31 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/(sici)1099-1654(199910/12)9:4<245::aid-rmv
更新日期:1999-10-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.666
更新日期:2010-11-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.1868
更新日期:2016-03-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.1802
更新日期:2015-01-01 00:00:00
abstract::Respiratory infections, especially those of the lower respiratory tract, remain a foremost cause of mortality and morbidity of children greater than 5 years in developing countries including Pakistan. Ignoring these acute-level infections may lead to complications. Particularly in Pakistan, respiratory infections acco...
journal_title:Reviews in medical virology
pub_type: 杂志文章
doi:10.1002/rmv.2024
更新日期:2019-03-01 00:00:00
abstract::Maternofetal transmission of cytomegalovirus (CMV) is the most common infectious cause of congenital malformation in developed countries. Maternal infection often results from close contact with infected children, and this may occur in day care centres (DCCs). A systematic review of observational studies was conducted...
journal_title:Reviews in medical virology
pub_type: 杂志文章,meta分析
doi:10.1002/rmv.2011
更新日期:2019-01-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.2031
更新日期:2019-03-01 00:00:00
abstract::Viruses are efficient carriers of genetic material between cells. They specifically recognise a target cell and utilise host functions for genome delivery to the replication site. A mature viral capsid emerging from an infected cell serves at least three distinct functions. It enables virus egress from the infected ce...
journal_title:Reviews in medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1099-1654(1998100)8:4<213::aid-rmv22
更新日期:1998-10-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/(sici)1099-1654(199901/03)9:1<31::aid-rmv2
更新日期:1999-01-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.314
更新日期:2001-05-01 00:00:00
abstract::HIV-1 and HIV-2 share many similarities including their basic gene arrangement, modes of transmission, intracellular replication pathways and clinical consequences: both result in AIDS. However, HIV-2 is characterised by lower transmissibility and reduced likelihood of progression to AIDS. The underlying mechanistic d...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.1739
更新日期:2013-07-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.2041
更新日期:2019-07-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.321
更新日期:2001-07-01 00:00:00
abstract::Type B coxsackieviruses (CV-B) frequently infect the central nervous system (CNS) causing neurological diseases notably meningitis and encephalitis. These infections occur principally among newborns and children. Epidemiological studies of patients with nervous system disorders demonstrate the presence of infectious v...
journal_title:Reviews in medical virology
pub_type: 杂志文章
doi:10.1002/rmv.2191
更新日期:2020-11-07 00:00:00
abstract::Respiratory syncytial virus (RSV) infection is the most common cause of bronchiolitis and pneumonia in the pediatric population worldwide. The immunopathology of RSV infection varies considerably and severe disease occurs only in a minority of the population. There are many factors (host, viral, and environmental) tha...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2019-03-01 00:00:00
abstract::Hepatitis E virus (HEV) is a positive-stranded RNA virus with a 7.2 kb genome that is capped and polyadenylated. The virus is currently unclassified: the organisation of the genome resembles that of the Caliciviridae but sequence analyses suggest it is more closely related to the Togaviridae. Hepatitis E virus is an e...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
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更新日期:2003-05-01 00:00:00
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更新日期:2010-03-01 00:00:00
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更新日期:2014-05-01 00:00:00
abstract::Vaccination is the current strategy for control and prevention of severe rotavirus infections, a major cause of acute, dehydrating diarrhoea in young children worldwide. Public health interventions aimed at improving water, food and sanitation are unlikely adequately to control the disease. The development of vaccines...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.411
更新日期:2004-03-01 00:00:00
abstract::Of all the nutrients, vitamin A has been the most extensively evaluated for its impact on immunity. There are three main forms of vitamin A, retinol, retinal and retinoic acid (RA) with the latter being most biologically active and all-trans-RA (ATRA) its main derivative. Vitamin A is a key regulator of the functions ...
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pub_type: 杂志文章,评审
doi:10.1002/rmv.2204
更新日期:2020-12-31 00:00:00