Abstract:
:Hepatitis E virus (HEV) is the leading cause of acute viral hepatitis worldwide and an emerging cause of chronic infection in immunocompromised patients. As with viral infections in general, immune responses are critical to determine the outcome of HEV infection. Accumulating studies in cell culture, animal models and patients have improved our understanding of HEV immunopathogenesis and informed the development of new antiviral therapies and effective vaccines. In this review, we discuss the recent progress on innate and adaptive immunity in HEV infection, and the implications for the devolopment of effective vaccines and immune-based therapies.
journal_name
Rev Med Viroljournal_title
Reviews in medical virologyauthors
Hakim MS,Ikram A,Zhou J,Wang W,Peppelenbosch MP,Pan Qdoi
10.1002/rmv.1964subject
Has Abstractpub_date
2018-03-01 00:00:00issue
2eissn
1052-9276issn
1099-1654journal_volume
28pub_type
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