Abstract:
:Amongst the 60 viral species reported to be associated with bats, 59 are RNA viruses, which are potentially important in the generation of emerging and re-emerging infections in humans. The prime examples of these are the lyssaviruses and Henipavirus. The transmission of Nipah, Hendra and perhaps SARS coronavirus and Ebola virus to humans may involve intermediate amplification hosts such as pigs, horses, civets and primates, respectively. Understanding of the natural reservoir or introductory host, the amplifying host, the epidemic centre and at-risk human populations are crucial in the control of emerging zoonosis. The association between the bat coronaviruses and certain lyssaviruses with particular bat species implies co-evolution between specific viruses and bat hosts. Cross-infection between the huge number of bat species may generate new viruses which are able to jump the trans-mammalian species barrier more efficiently. The currently known viruses that have been found in bats are reviewed and the risks of transmission to humans are highlighted. Certain families of bats including the Pteropodidae, Molossidae, Phyllostomidae, and Vespertilionidae are most frequently associated with known human pathogens. A systematic survey of bats is warranted to better understand the ecology of these viruses.
journal_name
Rev Med Viroljournal_title
Reviews in medical virologyauthors
Wong S,Lau S,Woo P,Yuen KYdoi
10.1002/rmv.520subject
Has Abstractpub_date
2007-03-01 00:00:00pages
67-91issue
2eissn
1052-9276issn
1099-1654journal_volume
17pub_type
杂志文章,评审abstract::Nucleotide sequences from a total of 421 HEV isolates were retrieved from Genbank and analysed. Phylogenetically, HEV was classified into four major genotypes. Genotype 1 was more conserved and classified into five subtypes. The number of genotype 2 sequences was limited but can be classified into two subtypes. Genoty...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.482
更新日期:2006-01-01 00:00:00
abstract::After the serendipitous discovery of HIV eradication in the "Berlin patient", interest has grown in curing HIV infection by replacing the patient's replication-competent blood cells with infection-resistant ones. At the same time, induced pluripotent stem cell technologies and genetic engineering have boosted cell the...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.1831
更新日期:2015-05-01 00:00:00
abstract::The influenza A virus genome consists of eight segmented, single-stranded, negative-sense RNAs. Each viral RNA (vRNA) segment forms a ribonucleoprotein (RNP) complex together with NPs and a polymerase complex, which is a fundamental unit for transcription and replication of the viral genome. Although the exact structu...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.666
更新日期:2010-11-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章
doi:10.1002/rmv.2024
更新日期:2019-03-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.1740
更新日期:2013-05-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.2147
更新日期:2021-01-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.373
更新日期:2002-11-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.461
更新日期:2005-09-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.1747
更新日期:2013-07-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.1964
更新日期:2018-03-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.499
更新日期:2006-05-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1099-1654(1998100)8:4<213::aid-rmv22
更新日期:1998-10-01 00:00:00
abstract::Three non-nucleoside reverse transcriptase inhibitors (NNRTIs) are currently available for treatment of HIV-1 as part of combination antiretroviral therapy. Oral dosing is administered three times daily for delavirdine (DLV), twice daily for nevirapine (NVP), and once daily for efavirenz (EFV). Rash is a common side e...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/1099-1654(200007/08)10:4<217::aid-rmv279>3
更新日期:2000-07-01 00:00:00
abstract::Hepatitis E virus (HEV) is a positive-stranded RNA virus with a 7.2 kb genome that is capped and polyadenylated. The virus is currently unclassified: the organisation of the genome resembles that of the Caliciviridae but sequence analyses suggest it is more closely related to the Togaviridae. Hepatitis E virus is an e...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.384
更新日期:2003-05-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.1952
更新日期:2017-11-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.398
更新日期:2003-09-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,meta分析
doi:10.1002/rmv.2011
更新日期:2019-01-01 00:00:00
abstract::Viruses are obligate parasites dependent on host cells for survival. Viral infection of a cell activates a panel of pattern recognition receptors that mediate antiviral host responses to inhibit viral replication and dissemination. Viruses have evolved mechanisms to evade and subvert this antiviral host response, incl...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.1892
更新日期:2016-09-01 00:00:00
abstract:AUTHOR CONTRIBUTION:FN performed the literature review and wrote the manuscript; STZ coauthored, edited, and reviewed the manuscript. ABSTRACT:Treatment response in Hepatitis C virus (HCV) has generated varied effects in patients. Recently, nonresponsive and relapse patients related to host and genotype variabilities ...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.2120
更新日期:2020-07-01 00:00:00
abstract::Viruses are intracellular pathogens that have to usurp some of the cellular machineries to provide an optimal environment for their own replication. An increasing number of reports reveal that many viruses induce modifications of nuclear substructures including nucleoli, whether they replicate or not in the nucleus of...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.614
更新日期:2009-07-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.2109
更新日期:2020-05-01 00:00:00
abstract::The common mucosal immune system (CMIS) consists of an integrated cross-communication pathway of lymphoid tissues made up of inductive and effector sites for host protection against pathogenic microorganisms. Major effector molecules of the CMIS include IgA antibodies and cytokines, chemokines and their corresponding ...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.307
更新日期:2001-03-01 00:00:00
abstract::Although epidemiological and molecular epidemiological (serotype, genotype, and lineage information) data are available for several major cities in Indonesia, there is yet to be a comprehensive national study of dengue in Indonesia over time. This study was conducted to provide a comprehensive epidemiology of circulat...
journal_title:Reviews in medical virology
pub_type: 杂志文章
doi:10.1002/rmv.2037
更新日期:2019-07-01 00:00:00
abstract::The immense difficulty in primary control of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infection by adaptive immune responses has been a topic of exceptional importance. CD8+ cytotoxic T lymphocytes (CTLs) do play a central role in primary resolution of viremia, but their potency in vi...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.577
更新日期:2008-09-01 00:00:00
abstract::The success of vaccination against measles in developed countries has significantly reduced the incidence of measles-related morbidity and mortality. However, measles is still the leading cause of mortality in children from underdeveloped countries due to low vaccination coverage, high transmissibility of the measles ...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.430
更新日期:2004-07-01 00:00:00
abstract::The mosquito-borne flavivirus, Japanese encephalitis virus (JEV), is the leading cause of virus-induced encephalitis globally and a major public health concern of several countries in Southeast Asia, with the potential to become a global pathogen. The virus is neurotropic, and the disease ranges from mild fever to sev...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.1868
更新日期:2016-03-01 00:00:00
abstract::Hepatitis E virus (HEV) is responsible for more than 50% of acute viral hepatitis cases in endemic countries. Approximately 2 billion individuals live in hepatitis E-endemic areas and, therefore, are at risk of infection. According to World Health Organization, HEV causes about 20.1 million infections and 70 000 death...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.1929
更新日期:2017-05-01 00:00:00
abstract::HIV-1 and HIV-2 share many similarities including their basic gene arrangement, modes of transmission, intracellular replication pathways and clinical consequences: both result in AIDS. However, HIV-2 is characterised by lower transmissibility and reduced likelihood of progression to AIDS. The underlying mechanistic d...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.1739
更新日期:2013-07-01 00:00:00
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journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.411
更新日期:2004-03-01 00:00:00
abstract::BK polyomavirus (BKPyV or BKV) is a non-enveloped, circular double-stranded DNA virus that may exceed 80% seroprevalence in adults. BKV infection typically occurs during childhood, and the majority of adults are latently infected. While BKV infection is rarely associated with clinical disease in most individuals, in i...
journal_title:Reviews in medical virology
pub_type: 杂志文章,评审
doi:10.1002/rmv.2102
更新日期:2020-07-01 00:00:00